Search results for "Mediator"
showing 10 items of 339 documents
Known knowns and known unknowns on behavior change interventions and mechanisms of action.
2020
Systematic reviews and meta-analyses of research play an important role in summarizing current knowledge on the efficacy of the behavior change techniques and mechanisms of action that comprise behavioral interventions. The current reviews in the science of behavior change (SOBC) special issue represent a ‘step change’ in evaluating current evidence on behavior change interventions and mechanisms. This concluding article outlines the key findings and emerging issues identified in the reviews (‘known knowns’), and summarizes the evidence gaps highlighted by the reviews that need to be addressed in future research (‘known unknowns’). Specifically, findings of the reviews indicate that: tests …
Inhibition of the pro-inflammatory mediators' production and anti-inflammatory effect of the iridoid scrovalentinoside.
2007
We have studied scrovalentinoside, an iridoid with anti-inflammatory properties isolated from Scrophularia auriculata ssp. pseudoauriculata, as an anti-inflammatory agent in different experimental models of delayed-type hypersensitivity. We found that scrovalentinoside reduced the edema induced by oxazolone at 0.5 mg/ear and sheep red blood cells at 10 mg/kg. The observed effect occurred during the last phase or inflammatory response; during the earlier phase or induction of the delayed-type hypersensitivity reaction, no significant activity was noted. Thus, scrovalentinoside reduced both the edema and cell infiltration in vivo and reduced lymphocyte proliferation in vitro, affecting the cy…
Associations Between the Residential Environment and Physical Activity in German College Students and the Role of Self-Efficacy as a Mediator
2014
Social-ecological models suggest that influences on physical activity should be examined on multiple levels, but most of the empirical studies in this area have investigated the different levels separately. To integrate the different levels, we examined self-efficacy with respect to physical exercise as a mediator of the relation between environmental characteristics and physical activity. In a cross-sectional German study, 1,292 college students completed a questionnaire that included measures of their perceived residential environment, self-efficacy, and physical activity. Structural equation modeling was used to assess direct and indirect effects on physical activity. The cycling and wa…
Self-efficacy as a mediator of the relationship between meaning in life and subjective well-being in cardiac patients
2019
BackgroundThe theoretical framework and empirical data suggest that the relationship between meaning in life and well-being might be mediated by self-efficacy. Based on the cognitive-affective processing system (CAPS), self-concordance model and empirical data, we assume that self-efficacy might also act as a mediator between meaning in life and subjective well-being in cardiac patients.Participants and procedureThis study was conducted in cardiology units in Poland. Patients who met the inclusion/exclusion criteria were approached by research assistants in the inpatient clinic and outpatient centre in a cardiology unit in Poland. Results of the 176 participants (82 women and 94 men) aged f…
Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Age…
2010
Nowadays, people are living much longer than they used to do, however they are not free from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and individuals, is a post-maturational process that, due to a diminished homeostasis and increased organism frailty, causes a reduction of the response to environmental stimuli and, in general, is associated to an increased predisposition to illness and death. However, the high incidence of death due to infectious, cardiovascular and cancer diseases underlies a common feature in these pathologies that is represented by dysregulation of both instructive and innate immunity. Several studies show that a low-grade s…
Médiateurs linguistiques et culturels dans l'ile de Lampedusa: une enquete
2020
The island of Lampedusa, in Sicily, has been in the news for years because of the landings of migrants (especially Africans). Our study is based on interviews with cultural mediators who work with NGOs and other hosting humanitarian organizations based on this extreme land of Europe. We intend to verify, through our interviews, what are the major cultural problems (Katan 2014 [1999]) in translation, the level of manipulation and the risks that translators must assume to accomplish their task.
Childhood Maltreatment, Pathological Personality Dimensions, and Suicide Risk in Young Adults
2018
Several studies have demonstrated that child maltreatment (psychological, physical, and sexual abuse, and neglect) may be a significant factor in the development of pathological personality traits that increase the risk for suicidal ideation and behavior from adolescence to adulthood. Currently, the challenge is to understand how different forms of early negative experiences render an individual prone to develop specific personality traits and, in turn, be more vulnerable to suicide risk. To understand the relationship between childhood maltreatment and personality dimensions in suicide risk, our study aims to explore the role of self-criticism and dependency, two different pathological per…
Competenze e limiti della nuova figura del mediatore di cui al D.Lgs. 28/2010
2012
Gli autori dopo aver ripercorso l'iter normativo che ha introdotto in Italia l'Istituto della Mediazione/Conciliazione, delineano la figura del mediatore e le sue competenze nell'ambito della valutazione del danno da responsabilità civile, soffermandosi inoltre sulle specifiche competenze necessarie per il mediatore chiamato ad assolvere il suo ruolo in que casi ove la proposta conciliativa deve prevdere una valutazione della pretesa stessa, l'accertamento del nesso causale ed al contempo del quantum risarcitorio.
Recent Probes of Standard and Non-standard Neutrino Physics With Nuclei
2019
We review standard and non-standard neutrino physics probes that are based on nuclear measurements. We pay special attention on the discussion of prospects to extract new physics at prominent rare event measurements looking for neutrino-nucleus scattering, such as the coherent elastic neutrino-nucleus scattering (CE$\nu$NS) that may involve lepton flavor violation (LFV) in neutral-currents (NC). For the latter processes several appreciably sensitive experiments are currently pursued or have been planed to operate in the near future, like the COHERENT, CONUS, CONNIE, MINER, TEXONO, RED100, vGEN, Ricochet, NUCLEUS etc. We provide a thorough discussion on phenomenological and theoretical studi…
Different Efficiency of Heat Shock Proteins (HSP) to Activate Human Monocytes and Dendritic Cells: Superiority of HSP60
2002
Abstract One essential immunoregulatory function of heat shock protein (HSP) is activation of the innate immune system. We investigated the activation of human monocytes and monocyte-derived dendritic cells (DC) by recombinant human HSP60, human inducible HSP72, and preparations of human gp96 and HSP70 under stringent conditions, in the absence of serum and with highly purified monocytes. HSP60 induced human DC maturation and activated human DC to secrete proinflammatory cytokines. HSP72 induced DC maturation to a lesser extent, but activated human monocytes and immature DC as efficiently as HSP60 to release proinflammatory cytokines. The independence of the effects of HSP60 and HSP72 from …