Search results for "Medo"

Naevus Comedonicus Immunohistochemical Features in Two Cases

2003

Sir, Naevus comedonicus was first described by Kofmann in 1895 (1). It was arranged in groups or linear patterns along Blaschko’s line and located on the face, neck, upper arms, chest and abdomen. It has been well documented that naevus comedonicus occurs as a single entity but occasionally in association with other disorders. The objective of this study was to analyse the clinical and immunohistochemical features of two patients with extensive naevus comedonicus arranged in groups and linear patterns without non-cutaneous abnormalities.

Folliculotropic Mycosis Fungoides With Flexural Eruptive Cysts and Comedones in a 14-Year-Old Boy

2021

Apparel sizing using trimmed PAM and OWA operators

2012

This paper is concerned with apparel sizing system design. One of the most important issues in the apparel development process is to define a sizing system that provides a good fit to the majority of the population. A sizing system classifies a specific population into homogeneous subgroups based on some key body dimensions. Standard sizing systems range linearly from very small to very large. However, anthropometric measures do not grow linearly with size, so they can not accommodate all body types. It is important to determine each class in the sizing system based on a real prototype that is as representative as possible of each class. In this paper we propose a methodology to develop an …

Extramammary Paget Disease of the Axilla Associated With Comedo-like Apocrine Carcinoma In Situ.

2002

Extramammary Paget disease of the axilla with underlying apocrine carcinoma has been reported only in six cases until now. This report deals with a seventh case characterized by the unique finding of comedo-like features evocative of large cell ductal breast carcinoma within an otherwise typical in situ apocrine carcinoma. This is characterized by spiral-shaped foci of epithelial proliferation with decapitation secretion and central masses of necrotic debris. A possible connection between the solid neoplasm and the overlying Paget disease is illustrated by a few apocrine-follicular units colonized by both the Paget cells and the structured adenocarcinoma. Here, although they display the sam…

Non-parametric approaches to the impact of Holstein heifer growth from birth to insemination on their dairy performance at lactation one

2012

SUMMARYParametric approaches have been used widely to model animal growth and study the impact of growth profile on performance. Individual variation is often not considered in such approaches. However, non-parametric modelling allows this. Such an approach, based on spline functions, was used to study the importance of growth profiles from age 0 to 15 months (i.e. insemination) on milk yield and composition in primiparous cows. A dataset of 447 heifers was used for analysis of growth performance; 296 of them were also used to study impact on lactation. All of them originated from a French experimental herd and were born between 1986 and 2006. Clustering methods were also tested. Comparison…

A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease.

2022

Purpose: The mediator (MED) multisubunit-complex modulates the activity of the transcriptional machinery, and genetic defects in different MED subunits (17, 20, 27) have been implicated in neurologic diseases. In this study, we identified a recurrent homozygous variant in MED11 (c.325C>T; p.Arg109Ter) in 7 affected individuals from 5 unrelated families. Methods: To investigate the genetic cause of the disease, exome or genome sequencing were performed in 5 unrelated families identified via different research networks and Matchmaker Exchange. Deep clinical and brain imaging evaluations were performed by clinical pediatric neurologists and neuroradiologists. The functional effect of the ca…

Comparative effectiveness of an angiotensin receptor blocker, olmesartan medoxomil, in older hypertensive patients

2018

The efficacy and safety of olmesartan medoxomil (OM) vs active control (AC) monotherapy among elderly patients aged 60‐79 years (N = 4487) was evaluated by meta‐analysis (25 studies). In all patients, change from baseline to end point in blood pressure (BP) was significantly greater with OM vs AC (−19.5/−11.9 vs −16.8/−10.7 mm Hg). Greater proportions of OM‐ vs AC‐treated patients achieved BP goals. In patients with impaired renal function (estimated glomerular filtration rate <60 mL/min/1.73 m(2)), OM treatment resulted in a greater mean change from baseline in systolic BP vs AC (−21.2 vs −18.7 mm Hg, respectively) and a greater proportion of patients achieving BP goals. These parameters w…