Search results for "Memory."
showing 10 items of 1949 documents
Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection.
2010
Th1 CD4(+) T cells and their derived cytokines are crucial for protection against Mycobacterium tuberculosis. Using multiparametic flow cytometry, we have evaluated the distribution of seven distinct functional states (IFN-gamma/IL-2/TNF-alpha triple expressors, IFN-gamma/IL-2, IFN-gamma/TNF-alpha or TNF-alpha/IL-2 double expressors or IFN-gamma, IL-2 or TNF-alpha single expressors) of CD4(+) T cells in individuals with latent M. tuberculosis infection (LTBI) and active tuberculosis (TB). We found that triple expressors, while detectable in 85-90%TB patients, were only present in 10-15% of LTBI subjects. On the contrary, LTBI subjects had significantly higher (12- to 15-fold) proportions of…
Cloned T helper cells reverting to a resting state develop increasing sensitivity in their antigen-mediated interaction with accessory cells.
1988
A cloned murine T cell line, KIII5, specific for the polypeptide poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys [(T,G)-A--L] was compared at different stages after antigenic stimulation with respect to the conditions required for the reinduction of growth by varying concentrations of antigen presented on different types of accessory cells (AC). We show that the dose of antigen necessary for inducing half maximal proliferation in the presence of splenic AC shifts to considerably lower concentrations when the T cell blasts revert to a resting state (100 micrograms/ml on day 7 to 10 micrograms/ml on day 21-35). During the same time period the expression of interleukin 2 (IL2) receptor and the reacti…
Introduction: 50 years after the General Education Act of 1970
2021
The commemorative opportunity is only a circumstance that prompts to investigate the General Education Act (LGE) of 1970 fifty years after its approval. Another more essential reason invites its study: to investigate with new analyzes and new perspectives on what the LGE meant for the modernization of the country and for the transition between Franco's education and constitutional education. This requires examining the precedents of the 1970 Law and paying attention to the place that the LGE has occupied in educational historiography, in which an evolution towards current historiographic trends is visible. In these highlights the study of international influences in the process of education…
The aftermath of resilience in the global world.
2018
Just as there is an aftermath of trauma, there is reason to think of an aftermath of resilience, different from the resilience capacities developed after a trauma. The aftermath of resilience reflects the ability to activate resilient memory in response to traumatic memory in order to rebuild oneself. This is a major challenge for the global mental health of our fragile societies. The challenge is significant for France, Europe and the world. Beyond the overuse of the word resilience in scientific literature and the media, it contributes to the methodology, epistemology and politics of resilience.
Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition.
2020
AbstractAmyloid-β precursor protein (APP) is central to the pathogenesis of Alzheimer’s disease, yet its physiological functions remain incompletely understood. Previous studies had indicated important synaptic functions of APP and the closely related homologue APLP2 in excitatory forebrain neurons for spine density, synaptic plasticity, and behavior. Here, we show that APP is also widely expressed in several interneuron subtypes, both in hippocampus and cortex. To address the functional role of APP in inhibitory neurons, we generated mice with a conditional APP/APLP2 double knockout (cDKO) in GABAergic forebrain neurons using DlxCre mice. These DlxCre cDKO mice exhibit cognitive deficits i…
Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function.
2022
Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly characterized. Here we describe how the presence of Blastocystis in the gut microbiome was associated with deficits in executive function and altered gut bacterial composition in a discovery (n = 114) and replication cohorts (n = 942). We also found that Blastocystis was linked to bacterial functions related to aromatic amino acids metabolism and folate-mediated pyrimidine and one-carbon metabolism. Blastocystis-associated shifts in bacterial functionality translated into …
Can Attention and Working Memory Impairments of Intimate Partner Perpetrators Explain Their Risky Decision Making?
2018
Intimate partner violence (IPV) perpetrators commonly exhibit deficits in a wide range of cognitive domains, such as attention, memory, and executive functions. Executive dysfunctions tend to be related to a preference for disadvantageous decisions, which could be explained by a pattern of focusing on positive outcomes (gains) while disregarding negative ones. Nonetheless, it is less clear whether risk-taking and decision-making problems should be attributed to motivational and/or emotional causes or to cognitive deficits in attention and/or working memory. The main goal of the present study was to examine whether IPV perpetrators can be distinguished from non-violent controls based on the…
How the mind is easily hooked on musical imagery
2009
Recent studies show that nearly all people living in western societies are affected by involuntary musical imagery, or “earworms”. It has been suggested that prior exposure to music is an important predictor of this phenomenon. In comparison, cognitive psychologists use the concepts of recency (serial position) and the priming effect (brief exposure) to describe similar memory features. The aim of this study was to explore the dynamics of involuntary musical imagery in relation to these memory concepts. Two experiments and a novel experimental manipulation to induce the experience were designed to investigate the topic. The experiments utilized a modified musical image scanning task to cue …
Electronic and Magnetic Properties of Li<sub>1.5</sub>Mn<sub>0.5</sub>As Alloys in the Cu<sub>2</sub>Sb Structure
2013
We investigated two formula-units of Li1.5Mn0.5As alloys, such as Li3MnAs2, in the Cu2Sb crystal structure using an ab-initio algorithm. By interchanging Mn with each Li located at different positions of the Li4As2unit cell, four separate alloys are formed. At the optimized lattice constant, two of these alloys are predicted to be ferromagnetic metals and the other two are half metals. The possibility of half metallicity in the first two is also explored. Both the modified Slater-Pauling-Kübler rule and the ionic model can characterize the magnetic moments of the half metals.
Heavy-Ion Radiation Impact on a 4Mb FRAM under Different Test Conditions
2015
The impact of heavy-ions on commercial Ferroelectric Memories (FRAMs) is analyzed. The influence of different test modes (static and dynamic) on this memory is investigated. Static test results show that the memory is prone to temporary effects occurring in the peripheral circuitry. Dynamic tests results show a high sensitivity of this memory to heavy-ions.