Search results for "Memory"

Study time effects in recognition memory.

2004

We empirically tested the assumption that study time increases recognition accuracy because the storage of information is better when study time is longer as Shiffrin and colleagues have reported, an assumption common to parallel models of recognition. In the present study with 123 subjects, we examined the effect of item strength on four measures: hit rate, false alarm rate, d′, and β, for a single-word recognition task with longer study times than those usually used in the literature. Analysis indicated significant increase for hit rate and d′ and a decrease in false alarm rate, as one goes from weak to stronger study conditions, and a change in ln(β) when study time is greater than 1 se…

Transcutaneous immunization with imiquimod is amplified by CD40 ligation and results in sustained cytotoxic T-lymphocyte activation and tumor protect…

1999

Transcutaneous immunization (TCI) using ligands of Toll-like receptors (TLRs) and cytotoxic T-lymphocyte (CTL) epitopes lead to the induction of potent T-cell responses. To characterize the efficacy of TCI-mediated CTL activation, we monitored the frequency and functional activity of specific CTL induced with TCI using the ovalbumin-derived epitope SIINFEKL composed in creme containing the synthetic TLR7 ligand R-837. We found that the frequency and activity decayed rapidly 10 d post-TCI. Consistently, no significant memory T-cell formation was detectable. In a prophylactic vaccination setting, TCI was protective against a lethal challenge with ovalbumin expressing EG.7 thymoma cells when t…

Pharmacological approaches in bipolar disorders and the impact on cognition: a critical overview

2012

Dias VV, Balanza-Martinez V, Soeiro-de-Souza MG, Moreno RA, Figueira ML, Machado-Vieira R, Vieta E. Pharmacological approaches in bipolar disorders and the impact on cognition: a critical overview. Objective:  Historically, pharmacological treatments for bipolar disorders (BD) have been associated with neurocognitive side-effects. We reviewed studies which assessed the impact of several psychopharmacological drugs on the neurocognitive function of BD patients. Method:  The PubMed database was searched for studies published between January 1980 and February 2011, using the following terms: bipolar, bipolar disorder, mania, manic episode, or bipolar depression, cross-referenced with cognitive…

Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation

2020

AbstractThe interphase nucleus is functionally organized in active and repressed territories defining the transcriptional status of the cell. However, it remains poorly understood how the nuclear architecture of neurons adapts in response to behaviorally relevant stimuli that trigger fast alterations in gene expression patterns. Imaging of fluorescently tagged nucleosomes revealed that pharmacological manipulation of neuronal activity in vitro and auditory cued fear conditioning in vivo induce nucleus-scale restructuring of chromatin within minutes. Furthermore, the acquisition of auditory fear memory is impaired after infusion of a drug into auditory cortex which blocks chromatin reorganiz…

RNA memory model: a RNA-mediated transcriptional activation mechanism involved in cell identity.

2010

Position-effect variegation (PEV) was discovered in Drosophila melanogaster in 1930 in a study of X-ray-induced chromosomal rearrangements. If a rearrangement places euchromatic genes adjacent to a region of centromeric heterochromatin, it gives a variegated phenotype that results from the random inactivation of genes by heterochromatin spreading from the breakpoint. After the establishment, the inactivation is henceforth clonally inherited. The vast majority of these modifiers were originally isolated in Drosophila as dominant mutations that suppressed or enhanced the variegation caused by a variegating white allele called white-mottled 4 (wm4). A large number of modifier genes alter PEV p…

New Characterization Methodology For Shape Memory Alloys

2011

Translating the Memory of the Holocaust: Thomas Geve’s Memoir

2020

espanolThis paper explores the most significant challenges of translating the memory of the Holocaust, focusing on the difficulties of transferring a survivor’s testimonial account to a different linguistic and cultural system. Because the concentration camp experience is inherently multicultural, and survivors have chosen to pen their ordeal in several languages, translation epitomizes a discipline that intertwines directly with the construction of universal collective memory. Consequently, translating Holocaust memoirs poses challenging questions on hermeneutics and deontology. Throughout the following pages, I will critically analyze my own Spanish rendition of Thomas Geve’s memoir, Guns…

Performance evaluation of the MPE-iFEC Sliding RS Encoding for DVB-H streaming services

2008

This article studies the performance of the Sliding RS Encoding (SRSE) in the transmission of streaming services in DVB-H (Digital Video Broadcasting - Transmission System for Handheld Terminals) networks. The SRSE forms part of a set of specifications called MPE-iFEC which has been recently defined in the DVB-SH (Digital Video Broadcasting - Satellite Services to Handheld Devices) standard and is fully compatible with the link layer of DVB-H. MPE-iFEC is capable of encoding information related to different datagram bursts in a jointly manner in order to counteract the long signal blockages expected in satellite reception. This is what is usually referred to as Multi-Burst Encoding (MBE) an…

Multi-resolution quality-based video coding system for DASH scenarios

2021

Today, more than 85% of Internet traffic has a multimedia component. Video streaming occupies a large part of this percentage mainly because this type of content is provided by the most used applications on the Internet (e.g. Twitch, TikTok, Disney+, YouTube, Netflix, etc.). Most of these platforms use HTTP Adaptive Streaming (HAS) to send this media content to end users in order to ensure a good quality of experience (QoE). But, this QoE should be guaranteed from the video to be transmitted, i.e., the video should have an adequate quality by minimizing the bitrate before transmission. In order to solve this issue, we present a system capable of encoding a video in several resolutions given…

Verbal and academic skills in children with early-onset type 1 diabetes

2010

Aim  Basic verbal and academic skills can be adversely affected by early-onset diabetes, although these skills have been studied less than other cognitive functions. This study aimed to explore the mechanism of learning deficits in children with diabetes by assessing basic verbal and academic skills in children with early-onset diabetes and in comparison children. In addition, the incidence of dyslexia (≤10th centile in reading speed or reading–spelling accuracy) was studied. Method  The performance of 51 children with early-onset diabetes (25 females, 26 males; mean age 9y 11mo, SD 4mo; range 9–10y) was compared with that of 92 children without diabetes (40 females, 52 males; mean age 9y 1…