Search results for "Memory"
showing 10 items of 2004 documents
Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man.
2015
Dendritic cells are (DC) highly specialized professional antigen-presenting cells (APC) that regulate immune responses, maintaining the balance between tolerance and immunity. Mechanisms via which they can promote central and peripheral tolerance include clonal deletion, inhibition of memory T cell responses, T cell anergy and induction of regulatory T cells. These properties have led to the analysis of human tolerogenic DC as a therapeutic strategy for induction or re-establishment of tolerance. In the recent years, numerous protocols for the generation of human tolerogenic DC have been developed and their tolerogenic mechanisms, including induction of regulatory T cells, are relatively we…
IL-2 Expression in Activated Human Memory FOXP3(+) Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors …
2012
The human CD4(+)FOXP3(+) T cell population is heterogeneous and consists of various subpopulations which remain poorly defined. Anergy and suppression are two main functional characteristics of FOXP3(+)Treg cells. We used the anergic behavior of FOXP3(+)Treg cells for a better discrimination and characterization of such subpopulations. We compared IL-2-expressing with IL-2-non-expressing cells within the memory FOXP3(+) T cell population. In contrast to IL-2-non-expressing FOXP3(+) cells, IL-2-expressing FOXP3(+) cells exhibit intermediate characteristics of Treg and Th cells concerning the Treg cell markers CD25, GITR, and Helios. Besides lower levels of FOXP3, they also have higher levels…
γδ T Cells Cross-Link Innate and Adaptive Immunity in Mycobacterium tuberculosis Infection
2011
Protective immunity against mycobacterial infections such asMycobacterium tuberculosisis mediated by interactions between specific T cells and activated antigen presenting cells. To date, many aspects of mycobacterial immunity have shown that innate cells could be the key elements that substantially may influence the subsequent adaptive host response. During the early phases of infection, innate lymphocyte subsets play a pivotal role in this context. Here we summarize the findings of recent investigations onγδT lymphocytes and their role in tuberculosis immunity.
Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis
2014
With 1.4 million deaths and 8.7 million new cases in 2011, tuberculosis (TB) remains a global health care problem and together with HIV and Malaria represents one of the three infectious diseases world-wide. Control of the global TB epidemic has been impaired by the lack of an effective vaccine, by the emergence of drug-resistant forms of Mycobacterium tuberculosis (Mtb) and by the lack of sensitive and rapid diagnostics. It is estimated, by epidemiological reports, that one third of the world's population is latently infected with Mtb, but the majority of infected individuals develop long-lived protective immunity, which controls and contains Mtb in a T cell-dependent manner. Development o…
Immunological Markers for PML Prediction in MS Patients Treated with Natalizumab
2015
International audience; Natalizumab (NTZ), a monoclonal antibody recognizing the alpha4 integrin chain, has been approved for the treatment of active multiple sclerosis, but expose to the onset of a rare side effect, progressive multifocal leukoencephalopathy (PML). Estimating the individual risk of PML in NTZ-treated patients is a major challenge, and therapeutic strategies are mainly guided by the overall PML risk assessed by identified risk factors: JC virus (JCV) seropositivity, treatment duration (with peak incidence after 24 months), and the previous use of immunosuppressive therapies. Given that this stratification does not yet allow a precise individual prediction of PML, other pred…
Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals
2019
Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signals driving rapid memory CTL reactivation have remained ill-defined. Viral infections can trigger the release of the alarmin interleukin-33 (IL-33) from non-hematopoietic cells. IL-33 signals through its unique receptor ST2 to promote primary effector expansion and activation of CTLs. Here, we show that the transcription factor STAT4 regulated the expression of ST2 on CTLs in vitro and in vivo in primary infections with lymphocytic choriomeningitis virus (LCMV). In the primary antiviral response, IL-33 enhanced effector differentiation and antiviral cytokine production in a CTL-intrinsic manne…
Les lieux de mémoire victimaire en Europe : une culture commune et concurrente
2020
Since the 1990s, memorials and museums devoted to the victims of the massacres perpetrated in the twentieth century have multiplied in Europe, then in the world. This social, political and cultural fact is new. It reveals a radical change in historical representation where for centuries, only the victorious hero was celebrated in official history. In this context, specific memory sites, called “victim memory places”, have emerged. The Second World War is the turning point in this history of memory. The memory of the Holocaust is the model. But other memories, often competing, have also developed recently.This study proposes to record this break in the long duration of the history. Where doe…
Memorias en conflicto: dialécticas de la violencia política en la novela vasca actual
2013
Este trabajo pretende abordar algunas de las particularidades de las representaciones de la violencia política en la novela actual en lengua vasca. A partir de la constatación de que en la sociedad vasca, como en toda sociedad, existe un conflicto entre memorias de violencias de distinto signo, el artículo pretende ilustrar cómo se han articulado cuestiones tales como las categorías de víctima y victimario, cuya distinción no es siempre nítida, o los orígenes de la violencia política en dos novelas vascas actuales: Soinujolearen semea (El hijo del acordeonista) de Bernardo Atxaga y Antzararen bidea (El camino de la oca) de Jokin Muñoz. El autor sostiene que estas novelas plantean dos modos …
Representaciones de la transición española en la novela actual: una indagación en la configuración de la cultura democrática
2013
La noción de la transición como “matriz” de nuestro tiempo presente, como mito fundador de la España contemporánea es, hoy, uno de los puntos fundamentales de los debates culturales más recientes de nuestro país. Si consideramos el proceso de cambio político de la transición a la democracia como el punto de partida del proyecto democrático español aún vigente, el surgimiento de una serie de novelas centradas en el mismo resulta tan sintomático como oportuno. Por ello, en este artículo tratamos de interrogar las condiciones en las que ha aparecido esta serie de novelas, sus presupuestos comunes y los distintos núcleos de discusión a los que apuntan. Desde el análisis de la producción de una …
Staging, neurocognition and social functioning in bipolar disorder.
2018
Introduction: Bipolar disorder (BD) is associated with significant neurocognitive and functional impairment, which may progress across stages. The ‘latent stage' of BD remains understudied. This cross-sectional study assessed staging, neurocognition and social functioning among BD patients and their healthy siblings.Methods: Four groups were included: euthymic type I BD patients in the early (n = 25) and late (n = 23) stages, their healthy siblings (latent stage; n = 23) and healthy controls (n = 21). All 92 subjects underwent a comprehensive neuropsychological battery of processing speed, verbal learning/memory, visual memory, working memory, verbal fluency, executive cognition, and motor …