Search results for "Memory"
showing 10 items of 2004 documents
NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase.
2013
Abstract Memory formation of activated CD8 T cells is the result of a specific combination of signals that promote long-term survival and inhibit differentiation into effector cells. Much is known about initial cues that drive memory formation, but it is poorly understood which signals are essential during the intermediate stages before terminal differentiation. NKG2D is an activating coreceptor on Ag-experienced CD8 T cells that promotes effector cell functions. Its role in memory formation is currently unknown. In this study, we show that NKG2D controls formation of CD8 memory T cells by promoting survival of precursor cells. We demonstrate that NKG2D enhances IL-15–mediated PI3K signalin…
Induction of secondary cytotoxic T-lymphocytes in vitro does not require cell proliferation.
1976
SummaryUsing a mouse in vitro allograft model, evidence has been obtained that, in contrast to the accepted view, the generation of cytotoxic effector function in T-lymphocytes does not necessarily require cell division.
High anti-JCPyV serum titers coincide with high CSF cell counts in RRMS patients
2020
Background: Progressive multifocal leukoencephalopathy (PML) can in rare cases occur in natalizumab-treated patients with high serum anti-JCPyV antibodies, hypothetically due to excessive blockade of immune cell migration. Objective: Immune cell recruitment to the central nervous system (CNS) was assessed in relapsing-remitting multiple sclerosis (RRMS) patients stratified by low versus high anti-JCPyV antibody titers as indicator for PML risk. Methods: Cerebrospinal fluid (CSF) cell counts of 145 RRMS patients were quantified by flow cytometry. Generalized linear models were employed to assess influence of age, sex, disease duration, Expanded Disability Status Scale (EDSS), clinical/radiol…
Automatic Temporal Expectancy: A High-Density Event-Related Potential Study
2013
How we compute time is not fully understood. Questions include whether an automatic brain mechanism is engaged in temporally regular environmental structure in order to anticipate events, and whether this can be dissociated from task-related processes, including response preparation, selection and execution. To investigate these issues, a passive temporal oddball task requiring neither time-based motor response nor explicit decision was specifically designed and delivered to participants during high-density, event-related potentials recording. Participants were presented with pairs of audiovisual stimuli (S1 and S2) interspersed with an Inter-Stimulus Interval (ISI) that was manipulated acc…
Computation of inverse functions in a model of cerebellar and reflex pathways allows to control a mobile mechanical segment.
2003
Abstract The command and control of limb movements by the cerebellar and reflex pathways are modeled by means of a circuit whose structure is deduced from functional constraints. One constraint is that fast limb movements must be accurate although they cannot be continuously controlled in closed loop by use of sensory signals. Thus, the pathways which process the motor orders must contain approximate inverse functions of the bio-mechanical functions of the limb and of the muscles. This can be achieved by means of parallel feedback loops, whose pattern turns out to be comparable to the anatomy of the cerebellar pathways. They contain neural networks able to anticipate the motor consequences …
The role of transcranial magnetic stimulation in the study of cerebellar cognitive function.
2007
Transcranial magnetic stimulation (TMS) allows non-invasive stimulation of brain structures. This technique can be used either for stimulating the motor cortex, recording motor evoked potentials from peripheral muscles, or for modulating the excitability of other non-motor areas in order to establish their necessity for a given task. TMS of the cerebellum can give interesting insights on the cerebellar functions. Paired-TMS techniques, delivering stimuli over the cerebellum followed at various interstimulus intervals by stimuli over the motor cortex, allow studying the pattern of connectivity between the cerebellum and the contralateral motor cortex in physiological as well as in pathologic…
Color encoding for polychromatic single-channel optical pattern recognition
2010
The common multichannel system for recognizing colored images is replaced by a color-encoded single-channel system. Amethod inspired by the Munsell color system is used for encoding the different colors as phase and amplitude functions. It is shown that for many practical cases the phase information part of the color code is sufficient for obtaining good results. An implementation based on a liquid-crystal television panel that works in a phase-modulation mode is suggested. Computer simulations that demonstrate the capabilities of the suggested method are given as well as a comparison with previously published multichannel performance.
Check in–check out intervention for supporting pupils’ behaviour: effectiveness and feasibility in Finnish schools
2018
Check In–Check Out (CICO) is a support programme for students with externalising problem behaviours. This study implemented in Finland is one of the first reports on the application of CICO in the European context. An experimental, multiple-baseline, single-case design is used to examine the effects of the CICO intervention on the problem behaviour and appropriate behaviour of three general education primary school pupils. The similarity of the observation data and the information provided in daily report card (DRC) are investigated to gauge the validity of the DRC assessments. The fidelity and social validity of the intervention are also analysed. CICO reduced problem behaviour in all pupi…
Does short-term odour memory increase with expertise? An experimental study with perfumers, flavourists, trained panellists and novices
2011
We have examined short-term memory performance for odour recognition as a function of expertise. Experts (perfumers and flavourists), trained panellists, and novices studied three sets of common and uncommon (perfumery and flavour raw materials) odours with intentional encoding instructions. The three sets included three, six and 12 odours, respectively. As expected, recognition performance indicated an expertise effect: hit rates increased with expertise, whereas false alarm rates decreased. This effect, however, is mediated by the type and number of odours. For common odours, the effect of expertise is significant only for the larger odour set. For uncommon odours, the effect of expertise…
A Metaphor for Identities in Transition through Urbanization and Globalization: Tofu and One Hundred Surnames
2019
The Chinese artist Chen Qiulin has been taking displacement and the resulting unrest in people’s identity as her persistent theme since the early 1990s. Focusing on a series of her works made since 2004 dealing explicitly with tofu and Chinese surnames, this paper examines her exploration of identities in transition in the context of China’s mass urbanization and globalization. By showing the artist’s conceptual evolution, her preference for materials and mediums, and her exhibition strategy, this paper explores two issues. First, it illuminates how the artist has transformed “tofu” and “surname” into a metaphor for the dilemma of identity under the urbanization in China. Second, it discuss…