Search results for "Meri"

Frames and weak frames for unbounded operators

2020

In 2012 G\u{a}vru\c{t}a introduced the notions of $K$-frame and of atomic system for a linear bounded operator $K$ in a Hilbert space $\mathcal{H}$, in order to decompose its range $\mathcal{R}(K)$ with a frame-like expansion. In this article we revisit these concepts for an unbounded and densely defined operator $A:\mathcal{D}(A)\to\mathcal{H}$ in two different ways. In one case we consider a non-Bessel sequence where the coefficient sequence depends continuously on $f\in\mathcal{D}(A)$ with respect to the norm of $\mathcal{H}$. In the other case we consider a Bessel sequence and the coefficient sequence depends continuously on $f\in\mathcal{D}(A)$ with respect to the graph norm of $A$.

Tracking of blood vessels motion from 4D-flow MRI data

2022

This paper presents a novel approach to track objects from 4D Flow MRI data. A salient feature of the proposed method is that it fully exploits the geometrical and dynamical nature of the information provided by this imaging modality. The underlying idea consists in formulating the tracking problem as a data assimilation problem, in which both position and velocity observations are extracted from the 4D Flow MRI data series. Optimal estate estimation is then performed in a sequential fashion via Kalman filtering. The capabilities of the method are extensively assessed in a numerical study involving synthetic and clinical data.

Adaptive Number Knowledge in Secondary School Students: Profiles and Antecedents

2019

Cited By :1 Export Date: 10 February 2021 Correspondence Address: McMullen, J.; Department of Teacher EducationFinland; email: jake.mcmullen@utu.fi The present study aims to examine inter-individual differences in adaptive number knowledge in secondary school students. Adaptive number knowledge is defined as a well-connected network of knowledge of numerical characteristics and arithmetic relations. Substantial and relevant qualitative differences in the strategies and expression of adaptive number knowledge have been found in primary school students still in the process of learning arithmetic. We present a study involving 879 seventh-grade students that examines the structure of individual…

Site-specific DBCO modification of DEC205 antibody for polymer conjugation

2018

The design of multifunctional polymer-based vectors, forming pDNA vaccines, offers great potential in cancer immune therapy. The transfection of dendritic immune cells (DCs) with tumour antigen-encoding pDNA leads to an activation of the immune system to combat tumour cells. In this work, we investigated the chemical attachment of DEC205 antibodies (aDEC205) as DC-targeting structures to polyplexes of P(Lys)-b-P(HPMA). The conjugation of a synthetic block copolymer and a biomacromolecule with various functionalities (aDEC205) requires bioorthogonal techniques to avoid side reactions. Click chemistry and in particular the strain-promoted alkyne-azide cycloaddition (SPAAC) can provide the req…

Improved SiRNA Loading of Cationic Nanohydrogel Particles by Variation of Crosslinking Density

2019

Acid‐Cleavable Poly(ethylene glycol) Hydrogels Displaying Protein Release at pH 5

2020

Abstract PEG is the gold standard polymer for pharmaceutical applications, however it lacks degradability. Degradation under physiologically relevant pH as present in endolysosomes, cancerous and inflammatory tissues is crucial for many areas. The authors present anionic ring‐opening copolymerization of ethylene oxide with 3,4‐epoxy‐1‐butene (EPB) and subsequent modification to introduce acid‐degradable vinyl ether groups as well as methacrylate (MA) units, enabling radical cross‐linking. Copolymers with different molar ratios of EPB, molecular weights (M n) up to 10 000 g mol−1 and narrow dispersities (Đ<1.05) were prepared. Both the P(EG‐co‐isoEPB)MA copolymer and the hydrogels showed pH‐…

Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study

2021

The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines. An interesting feature of this enzyme comes from its regulation mechanism, which involves its binding to an activating dimer before it can be catalytically functional. Once the trimer is formed, the reaction mechanism proceeds through the deprotonation of the lysine followed by the methyl-transfer reaction. Here we present a detailed exploration of the activation mechanism through a QM/MM approach focusing on both steps of the reaction, aiming to provide new…

Live imaging of developmental processes in a living meristem of Davidia involucrata (Nyssaceae)

2014

Morphogenesis in plants is usually reconstructed by scanning electron microscopy and histology of meristematic structures. These techniques are destructive and require many samples to obtain a consecutive series of states. Unfortunately, using this methodology the absolute timing of growth and complete relative initiation of organs remain obscure. To overcome this limitation, an in vivo observational method based on Epi-Illumination Light Microscopy (ELM) was developed and tested with a male inflorescence meristem (floral unit) of the handkerchief tree Davidia involucrata Baill. (Nyssaceae). We asked whether the most basal flowers of this floral unit arise in a basipetal sequence or, altern…

Rough McKean-Vlasov dynamics for robust ensemble Kalman filtering

2021

Motivated by the challenge of incorporating data into misspecified and multiscale dynamical models, we study a McKean-Vlasov equation that contains the data stream as a common driving rough path. This setting allows us to prove well-posedness as well as continuity with respect to the driver in an appropriate rough-path topology. The latter property is key in our subsequent development of a robust data assimilation methodology: We establish propagation of chaos for the associated interacting particle system, which in turn is suggestive of a numerical scheme that can be viewed as an extension of the ensemble Kalman filter to a rough-path framework. Finally, we discuss a data-driven method bas…

Actividad antioxidante y biodisponibilidad mineral de zumos de frutas adicionados de minerales y/o leche

2010

En los últimos años, la industria alimentaria ha incrementado su interés en el desarrollo de alimentos funcionales, siendo el enriquecimiento de bebidas a base de zumo de frutas con vitaminas y minerales uno de los métodos empleados. Esta estrategia persigue mejorar el estado nutricional de la población, o de grupos específicos de población y/o corregir posibles deficiencias en la ingesta diaria de vitaminas o minerales, debidas a cambios en los hábitos alimentarios. No obstante, se precisa un mayor conocimiento sobre las interacciones que puedan producirse entre los compuestos bioactivos de las bebidas a base de zumo de frutas y los minerales adicionados, o viceversa. Para ello, se estudia…