Search results for "Meri"
showing 10 items of 7596 documents
The Americans: nei panni del nemico. Sguardi, spazi, immaginazioni.
2014
El acceso al empleo público en el Perú y España [Análisis del Derecho Comparado en la regulación del empleo público].
2015
En las líneas secuenciales que ilustran esta investigación, encontrará un análisis del Derecho Comparado sobre el sistema de acceso al empleo público en Perú y España, incluidos los principios que los rigen, sus modos de acceso, tipos y procesos de evaluación y de selección, las estructuras de selección y otros muchos aspectos que integran el sistema de acceso al empleo público en la regulación de cada país. En ese sentido, en la primera parte de nuestra investigación encontramos un régimen de servicio civil estructural y organizativo diferente, que nos introdujo en la necesidad de establecer nociones básicas para permitir al lector entrar en el contexto de cada esquema de servicio público.…
Microchimerism in multiple sclerosis: The association between sex of offspring and MRI features in women with multiple sclerosis
2023
AimsDuring pregnancy, fetal cells can migrate to the mother via blood circulation. A percentage of these cells survive in maternal tissues for decades generating a population of fetal microchimeric cells (fMCs), whose biological role is unclear. The aim of this study was to investigate the association between the sex of offspring, an indirect marker of fMCs, and magnetic resonance imaging (MRI) features in women with multiple sclerosis (MS).MethodsWe recruited 26 nulliparous MS patients (NPp), 20 patients with at least one male son (XYp), and 8 patients with only daughters (XXp). Each patient underwent brain MR scan to acquire 3D-T2w FLAIR FatSat and 3D-T1w FSPGR/TFE. Lesion Segmentation To…
Microchimerism and multiple sclerosis: a study on the impact of the sex of offspring on clinical, radiological, and paraclinical features of maternal…
2023
Background. Multiple sclerosis (MS) is a chronic autoimmune disorder characterised by inflammation and neurodegeneration and representing one of the most common causes of neurologic disability among young adults. Over the last 40 years, several authors have confirmed the existence of fetal cells in maternal blood and their pregnancy-related origin, demonstrating that pregnancy may establish a long-term, low-grade chimeric state in women. The biological and clinical significance of fetal microchimeric cells (fMCs) in maternal health is largely unknown, although a role in autoimmune diseases have been hypothesised. Aims. The overarching aim of my PhD dissertation was to investigate the role o…
Inserimento di restringimenti e ponti in un modello diffusivo 2D di acque basse
2010
Gli effetti su una corrente, causati dalle pile di un ponte, o più in generale da strutture che riducono la sezione trasversale dell’alveo, risultano di particolare interesse per le variazioni idrometriche che comportano alla corrente stessa. Nonostante i numerosi studi teorici e sperimentali di letteratura, l’attuale modellistica numerica diffusiva non integra la presenza di tali manufatti nelle proprie tecniche risolutive. Nella presente memoria viene presentata la metodologia implementata nel modello diffusivo bidimensionale FLOW2D per la valutazione del rigurgito provocato da restringimenti della sezione trasversale, nonché dalla presenza delle campate. I profili di rigurgito ottenuti c…
A comprehensive guide to the physics and usage of PYTHIA 8.3
2022
This manual describes the PYTHIA 8.3 event generator, the most recent version of an evolving physics tool used to answer fundamental questions in particle physics. The program is most often used to generate high-energy-physics collision "events", i.e. sets of particles produced in association with the collision of two incoming high-energy particles, but has several uses beyond that. The guiding philosophy is to produce and reproduce properties of experimentally obtained collisions as accurately as possible. The program includes a wide ranges of reactions within and beyond the Standard Model, and extending to heavy ion physics. Emphasis is put on phenomena where strong interactions play a ma…
El uso del teléfono inteligente en los procesos de compra en el contexto omnicanal: comercio móvil y showrooming
2022
En el contexto del comercio electrónico, el teléfono inteligente o smartphone abre un nuevo canal, el canal móvil, y transforma los procesos de compra, avanzando hacia la omnicanalidad. El smartphone contribuye a la convergencia de los canales online y offline al generar sinergias en la interacción con el minorista a través de múltiples canales y puntos de contacto. El uso del smartphone se relaciona con el auge del showrooming, es decir, buscar información offline y comprar online. El objetivo general de esta Tesis Doctoral es estudiar el papel del smartphone en la reconfiguración de los procesos de compra en el contexto omnicanal, abordando su uso como dispositivo de compra y de informaci…
Polymeric nanoparticles for siRNA delivery: Production and applications
2017
Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…