Search results for "Metas"
showing 10 items of 1693 documents
Indacaterol/glycopyrronium/mometasone fixed dose combination for uncontrolled asthma
2021
INTRODUCTION Asthma symptoms can be relieved through a maintenance treatment combining long-acting β2-agonist and inhaled corticosteroids (LABA/ICS). However, for patients with inadequately controlled asthma, the LABA/ICS combination might not be sufficient. Under these conditions, clinical guidelines recommend the administration of inhaled long-acting muscarinic antagonists (LAMA) as an add-on therapy to LABA/ICS to better control asthma and improve lung function. For nearly two decades, the only LAMA to be approved on the market has been tiotropium. AREAS COVERED We reviewed recent clinical studies evaluating the safety and efficacy of LABA/LAMA/ICS fixed dose combinations by searching Pu…
Uniportal thoracoscopy combined with laparoscopy as minimally invasive treatment of esophageal cancer
2018
A 67-year-old man was referred to our attention for management of esophageal adenocarcinoma, localized at the level of the esophagogastric junction and obstructed the 1/3 of the esophageal lumen. Due to the extension of the disease (T3N1M0-Stage IIIA), the patient underwent neo-adjuvant chemo-radiation therapy and he was then scheduled for a minimally invasive surgical procedure including laparoscopic gastroplasty, uniportal thoracoscopic esophageal dissection and intrathoracic end-to-end esophago-gastric anastomosis. No intraoperative and post-operative complications were seen. The patient was discharged in post-operative day 9. Pathological study confirmed the diagnosis of adenocarcinoma …
Best Practice in Health Care
2021
This book aims to disseminate and review the latest interdisciplinary medical knowledge to provide information on best clinical practice for difficult-to-treat conditions. The chapters address various aspects and approaches to the management of medical conditions that are not fully understood. This is exemplified by complex immune and inflammatory interactions in cancer development and survival-prolonging repeat surgery for pulmonary metastases or advances in craniotomy techniques for intracranial hemorrhage. Other chapters address the quality of life of patients after pyeloplasty, parathyroidectomy, or physically debilitating ankylosing spondylitis. Additional chapters address primary cili…
Structures of stiff macromolecules of finite chain length near the coil-globule transition: A Monte Carlo simulation
2000
Using a coarse-grained model of a semiflexible macromolecule, the equilibrium shapes of the chain have been studied varying both the temperature and the chain stiffness. We have applied Monte Carlo techniques using the bond fluctuation model for a chain length of N = 80 effective monomers, and two different types of interactions: a potential depending on the angle between successive bonds along the chain to control the chain stiffness, and an attractive interaction between non-bonded effective monomers to model variable solvent quality. In a diagram of states where chain stiffness and inverse temperature and used as variables, we find regions where the chain exists as coil, as spherical glo…
Prospective computational design and in vitro bio-analytical tests of new chemical entities as potential selective CYP17A1 lyase inhibitors
2019
[EN] The development and advancement of prostate cancer (PCa) into stage 4, where it metastasize, is a major problem mostly in elder males. The growth of PCa cells is stirred up by androgens and androgen receptor (AR). Therefore, therapeutic strategies such as blocking androgens synthesis and inhibiting AR binding have been explored in recent years. However, recently approved drugs (or in clinical phase) failed in improving the expected survival rates for this metastatic-castration resistant prostate cancer (mCRPC) patients. The selective CYP17A1 inhibition of 17,20-lyase route has emerged as a novel strategy. Such inhibition blocks the production of androgens everywhere they are found in t…
Coupled normal fluid and superfluid profiles of turbulent helium II in channels
2015
We perform fully coupled two--dimensional numerical simulations of plane channel helium II counterflows with vortex--line density typical of experiments. The main features of our approach are the inclusion of the back reaction of the superfluid vortices on the normal fluid and the presence of solid boundaries. Despite the reduced dimensionality, our model is realistic enough to reproduce vortex density distributions across the channel recently calculated in three--dimensions. We focus on the coarse--grained superfluid and normal fluid velocity profiles, recovering the normal fluid profile recently observed employing a technique based on laser--induced fluorescence of metastable helium molec…
String dynamics and metastability of fully-heavy tetraquarks
2017
Multiquark states have been advocated to explain recent experimental data in the heavy-light sector, and there are already speculations about multiquarks containing only heavy quarks and antiquarks. With a rigorous treatment of the four-body problem in current quark models, full-charm $(cc\bar c\bar c)$ and full-beauty $(bb\bar b\bar b)$ tetraquarks are found to be unbound. Thus their stability should rely on more subtle effects that are not included in the simple picture of constituent quarks. The case of $(bc\bar b\bar c)$ might be more favorable if the naive color-additive model of confinement is replaced by a string-inspired interaction.
Role of the Δ Resonance in the Population of a Four-Nucleon State in the Fe56→Fe54 Reaction at Relativistic Energies
2016
The 54Fe nucleus was populated from a 56Fe beam impinging on a Be target with an energy of E=A ¼ 500 MeV. The internal decay via γ-ray emission of the 10þ metastable state was observed. As the structure of this isomeric state has to involve at least four unpaired nucleons, it cannot be populated in a simple two-neutron removal reaction from the 56Fe ground state. The isomeric state was produced in the low-momentum (-energy) tail of the parallel momentum (energy) distribution of 54Fe, suggesting that it was populated via the decay of the Δ0 resonance into a proton. This process allows the population of fournucleon states, such as the observed isomer. Therefore, it is concluded that the obser…
Sensitive laser spectroscopy on trapped barium ions by quenching with hydrogen
1983
The sensitivity of laser spectroscopy on barium ions stored in a radio frequency quadrupole trap was drastically increased by using hydrogen for quenching the optically pumped metastable states. The attained fluorescence intensity per ion permits the detection of single ions. The method will be applied to environmental studies on actinides.
Thermodynamic predictions of the formation of chalcogenide glasses
1985
The understanding of glass forming ability requires quantitative information on the stable and metastable phase equilibria of binary and multicomponent systems, particularly as a function of composition and temperature. This paper discusses the success of the use of Gibbs free energy curves for the supercooled liquid relative to the stable crystalline phases to describe glass forming ability. Applications are reported for the systems GeSe2-Se, Sb2Se3-Se and GeSe2-Sb2Se3 for which experimental minimal quenching rates are available. A strongly associated regular solution model for the liquid phase gives a predicted behaviour consistent with experimental data. The method is intended to apply t…