Search results for "Metas"

The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells

2013

In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from an epithelial to a highly invasive mesenchymal phenotype in estrogen receptor α-positive (ERα(+)) breast cancer cells. The transition from an epithelial- to a mesenchymal-like phenotype was characterized by reduced expression of ERα, HER-2/Neu overexpression and loss of CD24 surface receptor (CD24(-/low)). Importantly, expression of key epithelial-to-mesenchymal transition (EMT) markers and upregulation of the stemness gene SOX2 was linked to acquisition of stem cell-like properties such as the ab…

Solitary Necrotic Nodule of the Liver: Different Pathological Findings Express a Different Histogenesis

2008

Solitary necrotic nodule of the liver is a rare benign lesion the histogenesis of which is still debated. We here report the case of a patient who underwent laparoscopic cholecystectomy for gallstones and who was accidentally found to have a solitary necrotic nodule of 2 cm in the fifth segment of the liver. On the basis of the histological findings, the hypothesis that different pathogenetic mechanisms could be involved in the histogenesis of this lesion is discussed.

BIBF 1120/ nintedanib : a new triple angiokinase inhibitor-directed therapy in patients with non-small cell lung cancer.

2013

Abstract: Introduction: Several new targeted agents with anti-angiogenic properties have been developed recently, including vandetanib, sunitinib, sorafenib, bevacizumab and others. Tumor development, progression, metastasis are strongly linked to angiogenesis. Targeted agents like bevacizumab, a monoclonal antibody which targets VEGF, have been fully developed in several solid tumors. These new agents strongly advocate that targeting angiogenesis is one of the best approaches for cancer therapy. Areas covered: Those agents that target additional pro-angiogenic intracellular signaling pathways beyond VEGF signaling have also the potential to contribute to anticancer therapies. The authors p…

Visceral fat area as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with antiangiogenic age…

2011

Abstract Purpose. A better identification of patients who are more likely to benefit from vascular endothelial growth factor–targeted therapy is warranted in metastatic renal cell carcinoma (mRCC). As adipose tissue releases angiogenic factors, we determined whether parameters such as visceral fat area (VFA) were associated with outcome in these patients. Experimental Design. In 113 patients with mRCC who received antiangiogenic agents (bevacizumab, sunitinib, or sorafenib) (n = 64) or cytokines (n = 49) as first-line treatment, we used computed tomography to measure VFA and subcutaneous fat area (SFA). We evaluated associations linking body mass index (BMI), SFA, and VFA to time to progres…

Il trattamento della sordità improvvisa mediante cortisonico intratimpanico

2009

Correlations of the distribution of spin states in spin crossover compounds

1999

Abstract Short range correlations of the distribution of high spin (HS) and low spin (LS) states show up in thermal spin transition curves, decay curves of the light induced metastable HS state (LIESST state), and in structural features during the spin transitions. Correlations are due to short range interactions between the spin crossover molecules. Short range interactions may compete with omnipresent long range interactions and give rise to interesting spin transition phenomena. In this paper, the effect of correlations on the thermal spin transition in the mixed crystal system [Fe x Zn 1− x (pic) 3 ]Cl 2 ·EtOH (pic=picolylamine) is discussed. In particular the step in the thermal transi…

Pressure-Induced High Spin State in [Fe(btr)2(NCS)2]·H2O (btr = 4,4′-bis-1,2,4-triazole)

2000

Application of hydrostatic pressure (≤ 10.5 kbar) on the two-dimensional spin transition compound [Fe(btr)2(NCS)2]·H2O (btr = 4,4‘-bis-1,2,4-triazole) results in an unexpected stabilization of the HS state. On release of the pressure, the HS state is found to be partially trapped. After thermal relaxation of the metastable HS state obtained by the LIESST effect (light-induced excited spin state trapping), a pure LS state is obtained in contrast to the pressure experiments. This different behavior supports a structural phase transition as the likely basis of the pressure-induced HS state.

Kinetics of phase separation in thin films: simulations for the diffusive case.

2005

We study the diffusion-driven kinetics of phase separation of a symmetric binary mixture (AB), confined in a thin-film geometry between two parallel walls. We consider cases where (a) both walls preferentially attract the same component (A), and (b) one wall attracts A and the other wall attracts B (with the same strength). We focus on the interplay of phase separation and wetting at the walls, which is referred to as {\it surface-directed spinodal decomposition} (SDSD). The formation of SDSD waves at the two surfaces, with wave-vectors oriented perpendicular to them, often results in a metastable layered state (also referred to as ``stratified morphology''). This state is reminiscent of th…

Self-assembly of a bioelastomeric structure: solution dynamics and the spinodal and coacervation lines.

1990

The stability, metastability, and instability regions of aqueous solutions of a representative synthetic bioelastomeric polymer, poly (Val-Pro-Gly-Val-Gly), were determined by a combined use of elastic and quasi-elastic light scattering experiments. The approach followed here offers the attractive advantage of singling out the relevant contributions to the total scattering even in the presence of traces of noninteracting larger sized impurities. Conclusions so reached were checked by means of independent experiments. The present results provide descriptions of the very early events in the physics of bioelastogenesis in terms of general polymer science and phase transitions, and in terms of …

Ultrafast Photo-Dynamics of a Reversible Photochromic Spiropyran

2002

We report the first ultrafast ring closure kinetics of the merocyanine (MC) of a reverse photochromic spiropyran 1‘,3‘,3‘-trimethyl-6,8-dinitrospiro[2H-1-benzopyran-2,2-indoline] (6,8-dinitro BIPS) and its 1‘-(2-carboxyethyl) substituted derivative. The reaction is fast and essentially over in a few hundred picoseconds. The rate of MC-S1 state decay evaluated from transient absorbance can be correlated directly with the MC-S1 state lifetime as determined using stimulated and ordinary emission measurements. The recovery of the MC-S0 state from MC-S1 has a component with a lifetime of 60−78 ps in acetonitrile with a second component of 350−470 ps probably due to a metastable intermediate. We …