Search results for "Metas"
showing 10 items of 1693 documents
A randomized, open-label, multicentre, phase IV study evaluating palbociclib plus endocrine treatment versus a chemotherapy based treatment strategy …
2017
TPS1115 Background: Although endocrine based therapy is recommended as first-line treatment in metastatic breast cancer (MBC) in patients with an HER2-/HR+ tumour up to 50% of the patients receive chemotherapy. Palbociclib (P) a CDK4/6 inhibitor improves PFS by 42% in endocrine sensitive and resistant HER2-/HR+ MBC when added to an endocrine therapy (ET). Patients included in clinical trials are often criticised not to be representative for real world breast cancer patients. Methods: Patients with first-line HER2-/HR+ MBC who are candidate for mono-chemotherapy will be eligible to be randomised 1:1 to receive either P plus ET per label or mono-chemotherapy per investigator´s choice with or…
The HERBA trial: a retrospective study on patients (pts) with HER2-positive (HER2+ve) breast cancer (BC) and brain metastases (BMs)
2017
Harmonic generation in all-dielectric metasurfaces
2023
Nonlinear light generation is a key phenomenon in many optical systems. Recently, the field of nonlinear optics has moved to the miniaturization of conventional bulky components. Among all the new platforms that have been proposed, dielectric nanoscale resonators represent excellent candidates for light generation and manipulation. When arranged in periodic arrays, such high refractive index scattering components become an artificial material called metasurface. Several approaches for designing platforms with enhanced optical nonlinearities at moderate pump intensities have been proposed. In this chapter, we review the most recent results on second- and third-order nonlinear processes in hi…
Extracranial metastasizing solitary fibrous tumors (SFT) of meninges: Histopathological features of a case with long-term follow-up
2012
Extrapleural solitary fibrous tumors are uncommon mesenchymal neoplasms frequently observed in middle-aged adults and are classified, according to the WHO classification of soft tissue tumors, as part of the hemangiopericytoma tumor group. However, these two entities remain separated in the WHO classification of tumors of the central nervous system. In fact, meningeal solitary fibrous tumors are believed to be benign lesion and only in a minority of cases local relapses have been described, although detailed survival clinical studies on solitary fibrous tumors of meninges are rare. In contrast to hemangiopericytoma, which frequently shows distant extracranial metastases, such an event is ex…
Fundamentals of metastability exchange optical pumping in helium
2010
21 pages; International audience; Advances in metastability exchange optical pumping (MEOP) at high laser powers, but also at high gas pressures and high magnetic field strengths, has provided strong motivation for revisiting the understanding of the limitations of this powerful technique. A comprehensive model has been developped for improved description of the combined effects of OP, ME, and relaxation, and of detailed MEOP features observed over the broad range of operating conditions. A brief description is provided, with illustrative comparisons of computed and experimental results. This improved tool is used to explain the excellent photon efficiency of OP obtained at all field streng…
An accurate optical technique for measuring the nuclear polarisation of 3He gas
2010
12 pages; International audience; In the metastability exchange optical pumping cells of our on-site production unit and of our other experimental set-ups, we use a light absorption technique to measure the 3He nuclear polarisation. It involves weak probe beams at 1083 nm, that are either perpendicular or parallel to the magnetic field and cell axis, with suitable light polarisations. When metastability exchange collisions control the populations of the sublevels in the 23S state, absolute values of the 3He ground state nuclear polarisation are directly inferred from the ratio of the absorption rates measured for these probe beams. Our report focuses on the transverse detection scheme for w…
Nucleation and accretion of bioelastomeric fibers at biological temperatures and low concentrations.
1988
Quasi-elastic light scattering (QELS) studies are reported, which address the early stages of aggregation of the polypentamer poly(VPGVG). This reflects the major primary structural feature of native elastin. The study is focused on the region of the phase diagram which in both its temperature and concentration range is closest to the state of affairs occurring in the course of bioelastogenesis by progressive synthesis of the precursor protein. Results here reported allow for the first time a self-consistent view of the physics of elastogenesis, and specify the role of the region of metastability and of that of instability of the phase diagram in the non-chaotic, orderly formation of elasto…
Crystal structure of a new polytype in the V–P–O system: is ω-VOPO4 a dynamically stabilised metastable network?
2001
Abstract ω-VOPO 4 has been prepared by thermal decomposition of different oxovanadium hydrogen phosphates, namely VO(HPO 4 ) n H 2 O ( n =2( α ), 2(β) and 4) and β-NH 4 (VO 2 )(HPO 4 ). The ω-VOPO 4 phase only remains well crystallised at relatively high temperatures. Its crystal structure has been determined ab initio from X-ray powder diffraction data collected at 475°C. The cell is tetragonal (space group P4 2 /mmc) with a =4.8552(3) A and c =8.4301(6) A. Starting positional parameters were obtained by direct methods, and the structure was refined using Rietveld profile refinement principles. Disorder of two oxygen sublattices is observed. To rationalise some features of the crystal stru…
Moderate hypofractionated helical tomotherapy for localized prostate cancer: preliminary report of an observational prospective study.
2019
Objective: To report preliminary findings of a phase II study exploring the clinical outcomes of moderate hypofractionated radiotherapy performed with helical tomotherapy (HT) using computed tomography–magnetic resonance imaging–based planning for localized prostate cancer. Methods: The phase II prospective study received ethics approval from our institutional ethics committee. A dose of 60 Gy/20 fractions for low–intermediate risk prostate cancer by means of HT was explored. Primary endpoints of the study were acute and late gastrointestinal (GI) and genitourinary (GU) toxicities. Secondary endpoints were quality of life and biochemical-free survival. Results: A total of 35 patients were i…