Search results for "Methodology"
showing 10 items of 852 documents
Analysis of optimal temperature, pressure and binder quantity for the production of biocarbon pellet to be used as a substitute for coke
2019
In order to contribute to the decarbonization of the economy, efficient alternatives to coal and coke should be found not only in the power sector but also in the industrial sectors (like steel, silicon and manganese production) in which coal and coke are used as a reductant and for steel production also as a fuel. To this aim many research works have been focused on the development of a coke substitute based on woody biomass and known as “biocarbon”. There are still barriers to overcome, among them: the biocarbon low density, poor mechanical strength and high reactivity. In this paper a new biocarbon production methodology is proposed, based on: pyrolysis at 600 °C, densification (using py…
A Pareto optimal design approach for simultaneous control of thinning and springback in stamping processes
2009
One of the most relevant research issues in automotive field is focused on the reduction of stamped parts weight also increasing their strength. In this way, a strong research effort is developed on high strength steels which are widely utilized and they require a proper springback control. Springback reduction in sheet metal forming is a typical goal to be pursued which is conflicting with thinning reduction for instance. Thus, such problems can be considered as multi-objective ones characterized by conflicting objectives. What is more, nowadays, a great interest would be focused on the availability of a cluster of possible optimal solutions instead of a single one, particularly in an indu…
Engineering multi-agent systems using feedback loops and holarchies
2016
This paper presents a methodological approach for the engineering of Multi-Agent Systems using feedback loops as a first class concept in order to identify organizations. Feedback loops are a way for modeling complex systems that expose emergent behavior by means of a cause-effect loop between two levels called micro and macro levels of the system. The proposed approach principles consist in defining an abstract feedback loop pattern and providing activities and guidelines in order to identify and refine possible candidates for feedback loops during the analysis phase of the Aspecs methodology. This approach is illustrated by using an example drawn from the smart grid field.
A Methodology for Modeling and Optimizing Social Systems
2020
[EN] A system methodology for modeling and optimizing social systems is presented. It allows constructing dynamical models formulated stochastically, i.e., their results are given by confidence intervals. The models provide optimal intervention ways to reach the stated objectives. Two optimization methods are used: (1) to test strategies and scenarios and (2) to optimize with a genetic algorithm. The application case presented is a small nonformal education Spanish business. First, the model is validated in the 2008-2012 period, and subsequently, the optimal way to obtain a maximum profit in the 2013-2025 period is obtained using the two methods.
Creating a questionnaire for a scientific study
2016
Using questionnaires has become a permanent part of collecting data in scientific studies within the sphere of human sciences as well as other disciplines. It has been utilized already for nearly a century in collecting data. The first questionnaires were carried out on paper but nowadays there are e-questionnaires alongside it which can be carried out through e-mail or published on a social media platform (for example, Facebook). An often used method is also a survey which is carried out with a research project's own web page, association or company etc. A questionnaire has been considered as an actual scientific method of data collection since 1930s. However, it was already used a little …
Optimization of antioxidants extraction from peanut skin to prevent oxidative processes during soybean oil storage
2017
8 páginas, 3 figuras, 2 tablas
CLOVE: classification of genomic fusions into structural variation events
2017
Background A precise understanding of structural variants (SVs) in DNA is important in the study of cancer and population diversity. Many methods have been designed to identify SVs from DNA sequencing data. However, the problem remains challenging because existing approaches suffer from low sensitivity, precision, and positional accuracy. Furthermore, many existing tools only identify breakpoints, and so not collect related breakpoints and classify them as a particular type of SV. Due to the rapidly increasing usage of high throughput sequencing technologies in this area, there is an urgent need for algorithms that can accurately classify complex genomic rearrangements (involving more than …
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
2021
AbstractLong and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups using 1 degree of freedom (1df) interaction and 2df joint tests. Primary multi-ancestry analyses in 62,969 individuals in stage 1 identified 3 novel loci that were replicated in an additional 59,296 individuals in stage 2, including rs7…
Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning.
2017
Background TFIIS stimulates RNA cleavage by RNA polymerase II and promotes the resolution of backtracking events. TFIIS acts in the chromatin context, but its contribution to the chromatin landscape has not yet been investigated. Co-transcriptional chromatin alterations include subtle changes in nucleosome positioning, like those expected to be elicited by TFIIS, which are elusive to detect. The most popular method to map nucleosomes involves intensive chromatin digestion by micrococcal nuclease (MNase). Maps based on these exhaustively digested samples miss any MNase-sensitive nucleosomes caused by transcription. In contrast, partial digestion approaches preserve such nucleosomes, but intr…
Automated selection of homologs to track the evolutionary history of proteins
2018
Background The selection of distant homologs of a query protein under study is a usual and useful application of protein sequence databases. Such sets of homologs are often applied to investigate the function of a protein and the degree to which experimental results can be transferred from one organism to another. In particular, a variety of databases facilitates static browsing for orthologs. However, these resources have a limited power when identifying orthologs between taxonomically distant species. In addition, in some situations, for a given query protein, it is advantageous to compare the sets of orthologs from different specific organisms: this recursive step-wise search might give …