Search results for "Methylene"

showing 10 items of 821 documents

Convenient synthesis of pyrrolo[3,4-g]indazole

2013

Abstract The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of the pyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones key intermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQ of the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated at the National Cancer Institute of Bethesda and some derivatives showed modest activity.

IndazoleAnnulationTetrahydropyrrolo[3; 4-g]indazole; Hydroxymethyleneketones; Antiproliferative activity; RegioselectivityStereochemistryTetrahydropyrrolo[3Organic ChemistryRegioselectivity4-g]indazoleGrowth inhibitoryAntiproliferative activityPyrazoleRing (chemistry)Settore CHIM/08 - Chimica FarmaceuticaBiochemistryTetrahydropyrrolo[34-g]indazole Hydroxymethyleneketones Antiproliferative activity Regioselectivitychemistry.chemical_compoundRegioselectivitychemistryHydroxymethyleneketonesDrug DiscoveryMoietyIsoindoleTetrahedron
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Metal Phosphonates Based on {[(Benzimidazol‐2‐ylmethyl)imino]bis(methylene)}bis(phosphonic Acid): Syntheses, Structures and Magnetic Properties of th…

2006

Five compounds based on {[(benzimidazol-2-ylmethyl)imino]bis(methylene)}bis(phosphonic acid) [(C7H5N2)CH2N(CH2PO3H2)2], namely [M{(C7H5N2)CH2N(CH2PO3H)2}] [M = Mn (1), Fe (2), Co (3), Cu (4), Cd (5)] have been synthesized under hydrothermal conditions. These compounds are isostructural, crystallizing in the orthorhombic space group Pbca, with a = 15.331(2), b = 10.7150(16), and c = 16.715(2) A for 1; a = 15.320(3), b = 10.477(2), and c = 16.764(3) A for 2; a = 15.207(2), b = 10.4626(16), and c = 16.794(3) A for 3; a = 15.101(3), b = 10.3517(17), and c = 16.997(3) A for 4; and a = 15.4679(19), b = 10.8923(13), and c = 16.6175(19) for 5. Each compound shows a one-dimensional chain structure w…

Inorganic ChemistryBenzimidazolechemistry.chemical_compoundCrystallographyTransition metalchemistryHydrogen bondStereochemistrySupramolecular chemistryOrthorhombic crystal systemIsostructuralMethyleneMagnetic susceptibilityEuropean Journal of Inorganic Chemistry
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Stable Methylene- and Oxo-Bridged Monocyclopentadienyl Titanium Compounds. Molecular Structure of {Ti[μ-(η5-C5Me4SiMe2-O)]Me}2(μ-CH2)

2004

Thermolysis of {Ti[μ-(η5-C5Me4SiMe2-O)]Me2}2 affords the methylene-bridged titanium compound {Ti[μ-(η5-C5Me4SiMe2-O)]Me}2(μ-CH2), concurrent with the evolution of methane, the first example of a fu...

Inorganic Chemistrychemistry.chemical_compoundChemistryOrganic ChemistryPolymer chemistryInorganic chemistryThermal decompositionMoleculechemistry.chemical_elementPhysical and Theoretical ChemistryMethyleneMethaneTitaniumOrganometallics
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CO 2 Fixation and Activation by Cu II Complexes of 5,5″‐Terpyridinophane Macrocycles

2007

An aza-terpyridinophane receptor containing the polyamine 4,7,10,13-tetraazahexadecane-1,16-diamine linked through methylene groups to the 5,5″ positions of a terpyridine unit has been prepared and characterized (L). The acid-base behaviour, CuII speciation and ability to form ternary complexes (CuII-L-carbonate) have been explored by potentiometric titrations in 0.15 M NaClO4 and by UV/Vis and paramagnetic NMR spectroscopy. Comparisons are made with a previously reported terpyridinophane containing the polyamine 4,7,10-triazatridecane-1,13-diamine (L1). For this latter receptor, reductive coupling between indigo and carbon dioxide at indigo-modified electrodes produces carboxylated derivat…

Inorganic Chemistrychemistry.chemical_compoundchemistryPolymer chemistryCarbon fixationPotentiometric titrationInorganic chemistryNuclear magnetic resonance spectroscopyMethyleneTerpyridineTernary operationElectrochemistryPolyamineEuropean Journal of Inorganic Chemistry
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Experimental and theoretical study using DFT method for the competitive adsorption of two cationic dyes from wastewaters

2016

Abstract The adsorption of cationic dyes, Basic Yellow (BY28) and Methylene Blue (MB) on a new activated carbon from medlar species were studied in both single and binary system. Some experimental parameters, namely, pH, amount of adsorbent and contact time are studied. Quantum chemical results indicate that the adsorption efficiency was directly related to the dye electrophilicity power. Some theorical parameters were calculated and proved that MB is more electrophilic than BY28, than greatest interaction with surface sites. Kinetic study showed that the adsorption follows the pseudo-second-order model and Freundlich was the best model to describe the phenomenon in the single and binary sy…

Inorganic chemistryCationic polymerizationGeneral Physics and Astronomy02 engineering and technologySurfaces and InterfacesGeneral Chemistry010402 general chemistry021001 nanoscience & nanotechnologyCondensed Matter Physics01 natural sciences0104 chemical sciencesSurfaces Coatings and Filmschemistry.chemical_compoundAdsorptionchemistryElectrophilemedicineFreundlich equationReactivity (chemistry)Binary system0210 nano-technologyMethylene blueActivated carbonmedicine.drugApplied Surface Science
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Thermodynamic and kinetic control over the oxidation mechanism of the natural vanadyl porphyrin series (DPEP)VO in methylene chloride: electrogenerat…

2006

The electrochemical behavior of the natural (DPEP)VO series (where DPEP is the dianion deoxophylloerythroetioporphyrinate) is studied in methylene chloride. The investigated compounds, which were extracted from oil shales of Tarfaya (Morocco), exhibit a typical electrochemical behavior as compared to that of related synthetic vanadyl porphyrins. The electro-oxidation of (DPEP)VO is characterized by a splitting of the peaks when carried out at a glassy carbon electrode. This can be explained by two possible paths (CE and EC mechanisms) which are characterized by a “square diagram” where the chemical step, C, corresponds to a dimerization (radical–radical or substrate–substrate reaction). The…

Inorganic chemistryKinetics010402 general chemistryElectrochemistry01 natural sciencesChlorideKinetic controlCatalysislaw.inventionchemistry.chemical_compoundlawMaterials Chemistrymedicine[CHIM.COOR]Chemical Sciences/Coordination chemistryMethyleneSpectroscopyElectron paramagnetic resonanceComputingMilieux_MISCELLANEOUS010405 organic chemistryChemistry[ CHIM.COOR ] Chemical Sciences/Coordination chemistryGeneral ChemistryPorphyrin0104 chemical sciences[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry[ CHIM.THEO ] Chemical Sciences/Theoretical and/or physical chemistrymedicine.drug
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Tetraurea calix[4]arenes with sulfur functions: synthesis, dimerization to capsules, and self-assembly on gold.

2007

Various calix[4]arene derivatives, fixed in the cone conformation by decylether groups and functionalized at their wide rim by urea residues, were synthesized. In two compounds (4f,g) sulfur functions were attached to the urea groups via different spacers in order to allow binding to metal surfaces. While they exist as single molecules in polar solvents, tetraurea calix[4]arenes of this type (4) combine to form dimeric capsules in aprotic, apolar solvents. A solvent molecule is usually included in such a capsule, if no guest with a higher affinity is present. In the presence of an equimolar amount of the tetratosylurea 5, the exclusive formation of heterodimers, consisting of one molecule o…

Inorganic chemistrySupramolecular chemistryBiochemistryMass SpectrometryMetalchemistry.chemical_compoundElectrolytesPhenolsCationsPolymer chemistryElectrochemistryMoleculeUreaFerrous CompoundsPhysical and Theoretical ChemistryDichloromethaneMethylene ChlorideChloroformOrganic ChemistrySurface Plasmon ResonanceSolutionschemistryModels ChemicalSolubilityvisual_artProton NMRvisual_art.visual_art_mediumSolventsNanoparticlesSelf-assemblyChloroformGoldCyclic voltammetryCalixarenesDimerizationSulfurOrganicbiomolecular chemistry
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Tuning of the electronic and photophysical properties of ladder-type quaterphenyl by selective methylene-bridge fluorination

2016

The photophysics (spectral positions, band shapes, fluorescence quantum yields and lifetimes) of a series of fluorinated ladder type quaterphenyls L4P and L4P-Fn (n = 2, 4, 6) depend strongly on the degree and position of fluorine, despite the fact that substitution is not performed in the rings but only in methylene-bridges. This is driven by subtle differences in the molecular orbitals (MOs) participating in the electronic transitions, and in the vibronic pattern of the S0 and S1 electronic states as revealed by (TD)DFT calculations. Solid state spectra for n = 0, 2, 4 are similar to those of solution due to small intermolecular interactions as revealed by combined X-ray and (TD)DFT analy…

Intermolecular forceGeneral Physics and Astronomychemistry.chemical_element02 engineering and technologyMethylene bridge010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesFluorescenceSpectral line0104 chemical scienceschemistry.chemical_compoundCrystallographychemistryComputational chemistryAtomic electron transitionFluorineMolecular orbitalPhysical and Theoretical Chemistry0210 nano-technologyQuantum
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Tetra-CMPO-derivatives of calix[4]arenes fixed in the 1,3-alternate conformation

2010

Calix[4]arene derivatives fixed in the 1,3-alternate conformation and substituted at one side by four carbamoylmethylphosphine oxide (CMPO) residues were synthesised. Two CMPO groups are directly attached to the wide rim, while the second pair is bound to the narrow rim via a tri- or tetramethylene spacer. Similar compounds, in which two CMPO groups at the wide rim are combined with two picolinamide groups or two ionisable carboxylic groups at the narrow rim, were also prepared. Some of these calixarene derivatives were studied as extractants for lanthanides (La3+, Eu3+, Yb3+) and thorium (Th4+) from acidic solution into methylene chloride. For selected samples, stability constants in metha…

LanthanidebiologyInorganic chemistryGeneral ChemistryCrystal structurebiology.organism_classificationChloridechemistry.chemical_compoundchemistryCalixarenePolymer chemistrymedicineTetraTitrationMethanolMethylenemedicine.drugSupramolecular Chemistry
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Adamantylcalixarenes with CMPO groups at the wide rim: synthesis and extraction of lanthanides and actinides

2007

Abstract Starting from p -adamantylcalix[4]- and [6]arenes functionalized with carboxylic acid or ester groups at the adamantane nuclei, carbamoylmethylphosphine oxide (CMPO)-containing ligands of a novel type were synthesized. They were studied as extractants for a series of f-block elements including radioactive 152 Eu(III), 241 Am(III), 233 U(VI), and 239 Pu(IV). Tetrameric ligand 4b in which CMPO residues are connected to adamantane nuclei through methylene groups gave the best extraction results for lanthanides and actinides. For all the ligands the extraction efficiency does not decrease at higher nitric acid concentration. Although the discrimination between trivalent actinides and l…

Lanthanidechemistry.chemical_classificationChemistryLigandCarboxylic acidAdamantaneOrganic ChemistryExtraction (chemistry)ActinideBiochemistrychemistry.chemical_compoundNitric acidDrug DiscoveryMethyleneNuclear chemistryTetrahedron
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