Search results for "Mg"
showing 10 items of 492 documents
Multiple roles for ISWI in transcription, chromosome organization and DNA replication.
2003
ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication.
Ultraviolet light-induced apoptotic death is impaired by the HMG-CoA reductase inhibitor lovastatin.
2003
HMG-CoA reductase inhibitors (i.e., statins) attenuate C-terminal isoprenylation of Rho GTPases, thereby inhibiting UV-C-induced activation of c-Jun-N-terminal kinases/stress-activated protein kinases (JNKs/SAPKs). Inhibition of UV-C-triggered JNK/SAPK activation by lovastatin is due to inhibition of Rac-SEK1/MKK4-mediated phosphorylation of JNKs/SAPKs at Thr183/Tyr185. UV-C-stimulated phosphorylation of p38 kinase (Thr180/Tyr182) is also impaired by lovastatin. Cell killing provoked by UV-C irradiation was significantly inhibited by lovastatin. This was paralleled by a reduced frequency of chromosomal aberrations, accelerated recovery from UV-C-induced transient replication blockage, inhib…
Hypogonadism in β-thalassemic adolescents: A characteristic pituitary-gonadal impairment. The ineffectiveness of long-term iron chelation therapy
1990
The pituitary-gonadal function was studied in 18 beta-thalassemic female adolescents, 8 with delayed puberty and 10 with primary amenorrhea,treated with repeated transfusions and long-term iron chelation therapy by subcutaneous infusion. A 100 micrograms gonadotropin-releasing hormone (GnRH) test, a double-bolus GnRH test after estradiol administration in non-responders, a 400 micrograms thyrotropin-releasing hormone (TRH) test and a 'high dose' human menopausal gonadotropin (hMG) test were performed. LH and FSH peak levels were significantly lower in thalassemic patients than in controls, both in the 100 micrograms GnRH test (LH was 4.3 +/- 0.7 mIU/ml vs 40.8 +/- 6.0 mIU/ml and FSH 3.3 +/-…
Clinical indications for the use of cardiac MRI. By the SIRM Study Group on Cardiac Imaging
2013
Cardiac magnetic resonance (CMR) is considered an useful method in the evaluation of many cardiac disorders. Based on our experience and available literature, we wrote a document as a guiding tool in the clinical use of CMR. Synthetically we describe different cardiac disorders and express for each one a classification, I to IV, depending on the significance of diagnostic information expected.
Kurzemes un Zemgales hercogiste no 1561. - 1795.gadam latviešu historiogrāfijas vērtējumā
2018
Bakalaura darbs ir uzrakstīts ar mērķi analizēt Kurzemes un Zemgales hercogistes vēstures atspoguļojumu latviešu historiogrāfijā un apzināt vērtējumu galvenās tendences. Darbs veidots, ievērojot hronoloģiskos atskaites punktus, sākot ar hercogistes izveidošanos 1561.gadā un beidzot ar hercogistes inkorporāciju Krievijas impērijā 1795.gadā, atsevišķas nodaļas veltot galvenajai problēmai visā hercogistes pastāvēšanas laikā, proti hercogu cīņai ar muižniecību par varu un hercogu cīņai par dinastijas saglabāšanu un hercogistes pastāvēšanu. Analizējot zināmākā hercoga Jēkaba personības un darbības aprakstu un vērtējumu 20.gs. 20. – 30.gadu, trimdas un mūsdienu latviešu autoru darbos, tika konsta…
About the reliability of the Maximum Entropy Method in reconstructing electron density: the case of MgO
2006
Abstract The reliability of the Maximum Entropy Method (MEM) to reconstruct finite temperature electron density (ED) is here discussed, investigating the case of periclase (MgO). A theoretical electron density has been generated by quantum mechanic calculations and folded with a function simulating atomic thermal motion, in order to produce a reference errorless ED [ρ(r)REF]. The Fourier coefficients of ρ(r)REF have been calculated, and used as “observed” diffraction intensities to reconstruct via MEM the original ED. The electron density attained by MEM [ρ(r)MEM] and ρ(r)REF have been compared with each other (pixel-by-pixel and critical points) to assess the ability of MEM to retrieve EDs…
Kinetics of dimer F2 type center annealing in MgF2 crystals
2018
Authors are greatly indebted to V. Lisitsyn, A. Ch. Lushchik and R.Vila for stimulating discussions. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 633053. The views and opinions expressed herein do not necessarily reflect those of the European Commission. The calculations were performed using facilities of the Stuttgart Supercomputer Center (project DEFTD 12939).
A Newman property for BLD-mappings
2019
We define a Newman property for BLD-mappings and prove that for a BLD-mapping between generalized manifolds equipped with complete path-metrics, this property is equivalent to the branch set being porous when the codomain is LLC. peerReviewed
Local dimensions of measures on infinitely generated self-affine sets
2014
We show the existence of the local dimension of an invariant probability measure on an infinitely generated self-affine set, for almost all translations. This implies that an ergodic probability measure is exactly dimensional. Furthermore the local dimension equals the minimum of the local Lyapunov dimension and the dimension of the space. We also give an estimate, that holds for all translation vectors, with only assuming the affine maps to be contractive.
Combined pharmacological treatment of heterozygous familial hypercholesterolemia
1990
Combined therapy of heterozygous familial hypercholesterolemia using a non-systemically acting drug (bile acid sequestrants) and a systemically acting one is frequently employed in clinical practice. A brief review of this topic is presented, with particular emphasis on the use of cholestyramine combined with pravastatin, a new HMG CoA reductase inhibitor.