Search results for "Mg"
showing 10 items of 492 documents
The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity.
2012
Liver is the main detoxifying organ and therefore the target of high concentrations of genotoxic compounds, such as environmental carcinogens and anticancer drugs. Here, we investigated the usefulness of lovastatin, which is nowadays widely used for lipid lowering purpose, as a hepatoprotective drug following the administration of the anthracycline derivative doxorubicin in vivo. To this end, BALB/c mice were exposed to either a single high dose or three consecutive low doses of doxorubicin. Acute and subacute hepatotoxicities were analyzed with or without lovastatin co-treatment. Lovastatin protected the liver against doxorubicin-induced acute pro-inflammatory and pro-fibrotic stress respo…
Effect of Mg 2+ ions co-doping on luminescence and defects formation processes in Gd 3 (Ga,Al) 5 O 12 :Ce single crystals
2017
The work was supported by the Institutional Research Funding IUT02-26 of the Estonian Ministry of Education and Research and the project 16-15569S of the Czech Science Foundation.
Histocompatibility reaction in tissue and cells of the marine sponge Suberites domuncula in vitro and in vivo: central role of the allograft inflamma…
2001
Sponges (Porifera) are the phylogenetically oldest still extant metazoan phylum. Recently elements of their immune system have been cloned and analyzed, primarily from the demosponges Suberites domuncula and Geodia cydonium. By differential display, two genes were identified in S. domuncula, whose translation products are involved in graft rejection/fusion: the allograft inflammatory factor (AIF-1) and the Tcf-like transcription factor (TCF). Since the AIF-1 and TCF genes are upregulated in vivo after tissue transplantation, especially in allografts, we investigated whether this reaction can be monitored in vitro. Therefore, the autogeneic and the allogeneic mixed sponge cell reaction (MSCR…
Mycobacterium tuberculosis rezistences pret antibakteriālajiem līdzekļiem noteikšana ar bactec mgit sistēmu
2017
Mūsdienās tuberkuloze ir viena no biežākajiem pacientu nāves cēloņiem pasaulē. Tuberkulozi vairākumā gadījumu izraisa M.tuberculosis. Bakalaura darbā tika analizēta literatūra, lai saprastu M.tuberculosis rezistences mehānismus pret prettuberkulozes līdzekļiem. Praktiskajai daļai tika izmantota BACTEC MGIT sistēma M.tuberculosis rezistences noteikšanai, un arī tika izmantoti rezultāti, kas iegūti SIA „RAKUS” Tuberkulozes un plaušu slimību centra Mikobakterioloģijas laboratorijā un apkopoti laboratorijas informācijas sistēmā (LIS). Satistikas analīze liecina par to, ka pasaulē un Latvijā tuberkulozes gadījumu skaits samazinās un, pateicoties labām ārstēšanas stratēģijām, izārstēto cilvēku sk…
Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells
2011
Lovastatin (Lov), bisphosphonates (BP) and metformin (Met) are widely used drugs, having in common that they interfere with the mevalonate pathway (MP). The MP generates isoprene moieties required for the function of regulatory GTPases controlling cell proliferation and survival. Here, we addressed the question whether MP inhibitors interfere with the anti-tumor efficacy of anticancer drugs. We comparatively analyzed the effect of equitoxic doses of Lov, BP and Met on cell viability, cell cycle progression, apoptosis and DNA damage response (DDR) of human osteo- and fibrosarcoma cells exposed to doxorubicin or cisplatin. We found that Lov, BP and Met modulated the anticancer drug sensitivit…
TLR4 elimination prevents synaptic and myelin alterations and long-term cognitive dysfunctions in adolescent mice with intermittent ethanol treatment.
2015
The adolescent brain undergoes important dynamic and plastic cell changes, including overproduction of axons and synapses, followed by rapid pruning along with ongoing axon myelination. These developmental changes make the adolescent brain particularly vulnerable to neurotoxic and behavioral effects of alcohol. Although the mechanisms of these effects are largely unknown, we demonstrated that ethanol by activating innate immune receptors toll-like receptor 4 (TLR4), induces neuroinflammation and brain damage in adult mice. The present study aims to evaluate whether intermittent ethanol treatment in adolescence promotes TLR4-dependent pro-inflammatory processes, leading to myelin and synapti…
Novel combination of celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor ce…
2010
Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Celecoxib (Celebrex®) exhibits antitumor effects in human HCC cells, and its mechanism of action is mediated either by its ability to inhibit cyclooxygenase 2 (COX-2) or by a number of various other COX-2 independent effects. Proteasome inhibitors (PIs) can exert cell growth inhibitory and apoptotic effects in different tumor cell types, including HCC cells. The present study examined the interaction between celecoxib and the PI MG132 in two human liver tumor cell lines HepG2 and HA22T/VGH. Our data showed that each inhibitor reduced proliferation and induced apoptosis in a dose-dependen…
Mazo un vidējo uzņēmumu attīstība Zemgalē
2015
Bakalaura darba tēma ir Mazo un vidējo uzņēmumu attīstība Zemgalē. MVU Latvijā sastāda 99% no visiem uzņēmumiem un tiem ir ļoti būtiska nozīme tautsaimniecībā, jo tie tieši ietekmē bezdarba līmeni valstī un iedzīvotāju labklājību. Turklāt mazie un vidējie uzņēmumi rada lielāko daļu iekšzemes kopprodukta. Reģistrēto uzņēmu skaits ir strauji audzis kopš 2010. gada, taču liela daļa jauno uzņēmumu savu darbību pārtrauc pirmajos trīs gados, jo nākas saskarties ar dažādām attīstības problēmām, kā piemēram, nodokļu slogs, konkurence, mazs pieprasījums, kvalificētu darbinieku trūkums u. c. Attīstītākā uzņēmējdarbības vide ir Rīgā, kur arī ir reģistrēti vairāk kā puse Latvijas uzņēmumu. Sarežģītāk i…
De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise
2017
International audience; A series of simplex cases have been reported under various diagnoses sharing early aging, especially evident in congenitally decreased subcutaneous fat tissue and sparse hair, bone dysplasia of the skull and fingers, a distinctive facial gestalt, and prenatal and postnatal growth retardation. For historical reasons, we suggest naming the entity Fontaine syndrome. Exome sequencing of four unrelated affected individuals showed that all carried the de novo missense variant c.649C>T (p.Arg217Cys) or c.650G>A (p.Arg217His) in SLC25A24, a solute carrier 25 family member coding for calcium-binding mitochondrial carrier protein (SCaMC-1, also known as SLC25A24). SLC25A24 all…
Regional differences in mu-opioid receptor-dependent modulation of basal dopamine transmission in rat striatum
2016
Abstract The nigrostriatal dopamine system is implicated in the regulation of reward and motor activity. Dopamine (DA) release in dorsal striatum (DS) is controlled by the firing rate of DA neurons in substantia nigra pars compacta. However, influences at terminal level, such as those involving activation of mu opioid receptors (MORs), can play a key role in determining DA levels in striatum. Nonetheless, published data also suggest that the effect of opioid drugs on DA levels may differ depending on the DS subregion analyzed. In this study, in vivo microdialysis in rats was used to explore this regional dependence. Changes in basal DA levels induced by local retrodialysis application of DA…