Search results for "Mg"
showing 10 items of 492 documents
Soil Science Challenges in a New Era: A Transdisciplinary Overview of Relevant Topics
2020
Transdisciplinary approaches that provide holistic views are essential to properly understand soil processes and the importance of soil to society and will be crucial in the future to integrate distinct disciplines into soil studies. A myriad of challenges faces soil science at the beginning of the 2020s. The main aim of this overview is to assess past achievements and current challenges regarding soil threats such as ero-sion and soil contamination related to different United Nations sustainable development goals (SDGs) including (1) sustainable food production, (2) ensure healthy lives and reduce environmental risks (SDG3), (3) ensure water availability (SDG6), and (4) enhanced soil carbo…
Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
2011
Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell death, thus provoking an anticancer immune response. Here we demonstrate that autophagy, which is often disabled in cancer, is dispensable for chemotherapy-induced cell death but required for its immunogenicity. In response to chemotherapy, autophagy-competent, but not autophagy-deficient, cancers attracted dendritic cells and T lymphocytes into the tumor bed. Suppression of autophagy inhibited the release of adenosine triphosphate (ATP) from dying tumor cells. Conversely, inhibition of extracellular ATP-degrading enzymes increased pericellular ATP in autophagy-deficient tumors, reestablished the recr…
NF-κB Inhibition Restores Sensitivity to Fas-Mediated Apoptosis in Lymphoma Cell Lines
2003
Failure to perform the Fas-related apoptosis pathway can account for tumor resistance both to chemotherapeutic agents and to immunological effectors. We studied the role of NK-kappaB in Fas-resistance, employing the Fas-sensitive human T-lymphoma HuT78 cell line and its Fas-resistant variants HuT78B1 and HuT78G9. All these cell lines expressed high levels of constitutively activated NF-kappaB. Pretreatment of cells with NF-kappaB inhibitors (PDTC, MG132, or SN50) strongly enhanced CH11-induced apoptosis in HuT78 and Hut78G9 cells, while only MG132 showed a similar potentiating effect in HuT78B1. The described synergism was significantly inhibited by pretreatment with the anti-Fas-blocking a…
Singular quasisymmetric mappings in dimensions two and greater
2018
For all $n \geq 2$, we construct a metric space $(X,d)$ and a quasisymmetric mapping $f\colon [0,1]^n \rightarrow X$ with the property that $f^{-1}$ is not absolutely continuous with respect to the Hausdorff $n$-measure on $X$. That is, there exists a Borel set $E \subset [0,1]^n$ with Lebesgue measure $|E|>0$ such that $f(E)$ has Hausdorff $n$-measure zero. The construction may be carried out so that $X$ has finite Hausdorff $n$-measure and $|E|$ is arbitrarily close to 1, or so that $|E| = 1$. This gives a negative answer to a question of Heinonen and Semmes.
Putative high mobility group non-histone chromosomal proteins from pea (Pisum sativum)
1991
Abstract Three putative HMG proteins, 1P, 2P and 3P have been isolated from pea ( Pisum sativum L. cv. Lincoln) nuclei by extraction with either 5% perchloric acid or 0.35 M NaCl and purified by preparative electrophoresis. The amino acid analysis showed many of the typical features of the HMG proteins, although 1P and 2P possess a somewhat reduced content of acidic amino acids and 3P has less than 20% basic amino acids. Peptide mapping with Staphylococcus aureus V8 protease suggested that none of the proteins are proteolytic products of histone H1.
Sub-Finsler Horofunction Boundaries of the Heisenberg Group
2020
We give a complete analytic and geometric description of the horofunction boundary for polygonal sub-Finsler metrics---that is, those that arise as asymptotic cones of word metrics---on the Heisenberg group. We develop theory for the more general case of horofunction boundaries in homogeneous groups by connecting horofunctions to Pansu derivatives of the distance function.
Local multifractal analysis in metric spaces
2013
We study the local dimensions and local multifractal properties of measures on doubling metric spaces. Our aim is twofold. On one hand, we show that there are plenty of multifractal type measures in all metric spaces which satisfy only mild regularity conditions. On the other hand, we consider a local spectrum that can be used to gain finer information on the local behaviour of measures than its global counterpart.
Bing meets Sobolev
2019
We show that, for each $1\le p < 2$, there exists a wild involution $\mathbb S^3\to \mathbb S^3$ in the Sobolev class $W^{1,p}(\mathbb S^3,\mathbb S^3)$.
A proof of Carleson's $\varepsilon^2$-conjecture
2019
In this paper we provide a proof of the Carleson $\varepsilon^2$-conjecture. This result yields a characterization (up to exceptional sets of zero length) of the tangent points of a Jordan curve in terms of the finiteness of the associated Carleson $\varepsilon^2$-square function.
Notions of Dirichlet problem for functions of least gradient in metric measure spaces
2019
We study two notions of Dirichlet problem associated with BV energy minimizers (also called functions of least gradient) in bounded domains in metric measure spaces whose measure is doubling and supports a (1, 1)-Poincaré inequality. Since one of the two notions is not amenable to the direct method of the calculus of variations, we construct, based on an approach of Juutinen and Mazón-Rossi–De León, solutions by considering the Dirichlet problem for p-harmonic functions, p>1, and letting p→1. Tools developed and used in this paper include the inner perimeter measure of a domain. Peer reviewed