Search results for "Microfluidics"
showing 10 items of 121 documents
Polylactic is a Sustainable, Low Absorption, Low Autofluorescence Alternative to Other Plastics for Microfluidic and Organ-on-Chip Applications
2020
Organ-on-chip (OOC) devices are miniaturized devices replacing animal models in drug discovery and toxicology studies. The majority of OOC devices are made from polydimethylsiloxane (PDMS), an elastomer widely used in microfluidic prototyping, but posing a number of challenges to experimentalists, including leaching of uncured oligomers and uncontrolled absorption of small compounds. Here we assess the suitability of polylactic acid (PLA) as a replacement material to PDMS for microfluidic cell culture and OOC applications. We changed the wettability of PLA substrates and demonstrated the functionalization method to be stable over a time period of at least 9 months. We successfully cultured …
Active and Passive Motion in Complex pH‐Fields
2021
Microfluidic Synthesis of Liquid Crystalline Elastomer Particle Transport Systems which Can Be Remote‐Controlled Magnetically
2019
Segmented Flow-Based Multistep Synthesis of Cadmium Selenide Quantum Dots with Narrow Particle Size Distribution
2015
A continuous-flow microreactor was used to synthetize II-VI semiconductor quantum dots (CdSe). In order to improve the size distribution of the nanoparticles, the synthesis was carried out in a two-step procedure. A seed solution was obtained in a separate nucleation step, followed by a controllable growth step. Quantum dots that are synthesized with the two-step method show a much narrower size distribution in comparison to those obtained in a conventional batch synthesis.
Hyaluronic acid based nanohydrogels fabricated by microfluidics for the potential targeted release of Imatinib: Characterization and preliminary eval…
2019
Abstract Microfluidics is emerging as an innovative technique for the “on chip” fabrication of nanoparticles for drug delivery applications. Here, by using an amphiphilic derivative of hyaluronic acid as a starting macromolecule, nanohydrogels loaded with Imatinib were produced by the microfluidic procedure in order to develop an innovative therapeutic tool for the treatment of retinal neovascularization. Both cyRGDC functionalized and non-functionalized nanohydrogels were designed and fabricated by using the same technique. The targeting efficiency of the obtained nanosystems was studied in vitro on human retinal pigment epithelial cells (HRPEpiC) and human umbilical vein endothelial cells…
Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics
2015
The airway epithelium is exposed to a variety of harmful agents during breathing and appropriate cellular responses are essential to maintain tissue homeostasis. Recent evidence has highlighted the contribution of epithelial barrier dysfunction in the development of many chronic respiratory diseases. Despite intense research efforts, the responses of the airway barrier to environmental agents are not fully understood, mainly due to lack of suitable in vitro models that recapitulate the complex in vivo situation accurately. Using an interdisciplinary approach, we describe a novel dynamic 3D in vitro model of the airway epithelium, incorporating fully differentiated primary human airway epith…
Synergies between Hyperpolarized NMR and Microfluidics: A Review
2021
Hyperpolarized nuclear magnetic resonance and lab-on-a-chip microfluidics are two dynamic, but until recently quite distinct, fields of research. Recent developments in both areas increased their synergistic overlap. By microfluidic integration, many complex experimental steps can be brought together onto a single platform. Microfluidic devices are therefore increasingly finding applications in medical diagnostics, forensic analysis, and biomedical research. In particular, they provide novel and powerful ways to culture cells, cell aggregates, and even functional models of entire organs. Nuclear magnetic resonance is a non-invasive, high-resolution spectroscopic technique which allows real-…
Current trends in affinity-based monoliths in microextraction approaches: A review
2019
Abstract This article reviews the research contributions along the past five years concerning to monolithic materials for the development of affinity-based sorbents in the field of microextraction techniques. The first part of this paper includes an introduction regarding monolithic affinity media and information of different binding agents (such as immunoglobulin-binding proteins, enzymes, lectins, antibodies, aptamers, dyes and immobilized metal ions and nanoparticles, among others) that can act as affinity ligands. Then, the preparation of monoliths and ligand immobilization strategies as well as the different available formats (syringes, pipette tips, spin columns, capillaries, disks an…
ELECTROCHEMICAL CONVERSION OF DICHLOROACETIC ACID TO CHLOROACETIC ACID IN A MICROFLUIDIC STACK AND IN A SERIES OF MICROFLUIDIC REACTORS
2015
The electrochemical conversion of dichloroacetic acid to chloracetic acid was performed in three different micro devices: a simple micro fluidic cell; a microfluidic stack equipped with various electrode chambers in series and three micro fluidic cells in series. The electrochemical synthesis of chloracetic acid was performed successfully with high yields and selectivity under a single-pass mode without supporting electrolyte at low cell voltages. An increase of the productivity and of the final concentration of the target product was achieved by using a stack with two or three electrode chambers in series. The utilization of three micro reactors in series open interesting new perspectives,…
M6_Microfluidics_for_CNT
2018
The hydrodynamic trap holds an incoming droplet until the arrival of following droplet. The previous droplet leaves the trap in very rapid manner.