Hyaluronic acid based nanohydrogels fabricated by microfluidics for the potential targeted release of Imatinib: Characterization and preliminary evaluation of the antiangiogenic effect

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RESEARCH PRODUCT

Hyaluronic acid based nanohydrogels fabricated by microfluidics for the potential targeted release of Imatinib: Characterization and preliminary evaluation of the antiangiogenic effect

Bongiovi Flavia Fiorica Calogero Palumbo Fabio Salvatore Pitarresi Giovanna Giammona Gaetano

subject

Cell Survival Drug Compounding Hyaluronic acid Microfluidics Microfluidics Pharmaceutical Science Angiogenesis Inhibitors 02 engineering and technology Retinal Pigment Epithelium 030226 pharmacology & pharmacy THERAPY Umbilical vein ANGIOGENESIS Neovascularization 03 medical and health sciences chemistry.chemical_compound Nanoparticle 0302 clinical medicine Lab-On-A-Chip Devices Amphiphile Hyaluronic acid medicine Human Umbilical Vein Endothelial Cells Humans PEPTIDE DRUG-DELIVERY Neovascularization Drug Carriers Chemistry Imatinib Hydrogels 021001 nanoscience & nanotechnology RANIBIZUMAB VEGF In vitro Choroidal Neovascularization Nanostructures INTEGRINS Microfluidic Drug delivery Imatinib Imatinib Mesylate Feasibility Studies Nanoparticles medicine.symptom Targeted delivery 0210 nano-technology Biomedical engineering medicine.drug

description

Abstract Microfluidics is emerging as an innovative technique for the “on chip” fabrication of nanoparticles for drug delivery applications. Here, by using an amphiphilic derivative of hyaluronic acid as a starting macromolecule, nanohydrogels loaded with Imatinib were produced by the microfluidic procedure in order to develop an innovative therapeutic tool for the treatment of retinal neovascularization. Both cyRGDC functionalized and non-functionalized nanohydrogels were designed and fabricated by using the same technique. The targeting efficiency of the obtained nanosystems was studied in vitro on human retinal pigment epithelial cells (HRPEpiC) and human umbilical vein endothelial cells (HUVEC), the latter chosen as generic cellular model to assay inhibiting effect on cellular sprouting of Imatinib loaded nanohydrogels. The suitability of microfluidic approach for nanohydrogel production and drug loading was demonstrated. The cyRGDC functionalized nanosystems loaded with Imatinib, showed in vitro an enhanced ability to inhibit HUVEC organization into a capillary like structure.

year	journal	country	edition	language
2019-09-05

10.1016/j.ijpharm.2019.118851 https://publications.cnr.it/doc/434306