Search results for "Micrography"

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CD3 immunohistochemistry is helpful in the diagnosis of giant cell arteritis.

2018

Objective. To evaluate whether CD3 staining performed routinely on temporal artery biopsy specimens might improve the sensitivity of temporal artery biopsy in patients with biopsy-negative GCA. Methods. Two hundred and seventy biopsies were considered for this study, stained with haematoxylin and eosin and with an anti-CD3 antibody. Results. The addition of CD3 staining modified the sensibility and the specificity of the histologic examination in 89.47 and 95.00%, respectively, with a positive and negative predictive values of 97.00 and 79.78%. Conclusion. The addition of CD3 immunostaining to the classic histologic evaluation is accompanied by a significant increase in the sensibility with…

giant cell arteritiMalePhotomicrographyPathologymedicine.medical_specialtyCD3 ComplexBiopsyGiant Cell ArteritisHaematoxylin03 medical and health scienceschemistry.chemical_compound0302 clinical medicineRheumatologyRetrospective StudiePositive predicative valueBiopsymedicineHumansPharmacology (medical)030212 general & internal medicineAgedRetrospective Studies030203 arthritis & rheumatologyAged 80 and overmedicine.diagnostic_testEosinbusiness.industryBiomarkerMiddle Agedmedicine.diseaseCD3ImmunohistochemistryStainingTemporal ArteriesdiagnosiSettore MED/16 - ReumatologiaGiant cell arteritischemistryROC CurveAged; Aged 80 and over; Biomarkers; Biopsy; CD3 Complex; Female; Giant Cell Arteritis; Humans; Immunohistochemistry; Male; Middle Aged; Photomicrography; ROC Curve; Retrospective Studies; Temporal ArteriesImmunohistochemistryFemalebusinessImmunostainingBiomarkersHumanRheumatology (Oxford, England)
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