Search results for "Migration"

Different integrins mediate cell spreading, haptotaxis and lateral migration of HaCaT keratinocytes on fibronectin

2000

Collaborative role of various fibronectin-binding integrins (alpha5beta1, alphavbeta1 and alphavbeta6) as mediators of cell adhesion and migration on fibronectin was studied using cultured HaCaT keratinocytes. This cell line spontaneously expressed all three fibronectin-binding integrins. In addition, the expression of alphavbeta6 integrin was strongly and specifically upregulated by transforming growth factor-beta1 (TGFbeta1) whereas the amount of other integrins remained practically unchanged on the cell surface. Adhesion, spreading and motility of HaCaT keratinocytes on fibronectin were promoted by TGFbeta1. Based on antibody blocking experiments, both untreated and TGFbeta1-treated HaCa…

The Ras/Raf-1/MEK1/ERK Signaling Pathway Coupled to Integrin Expression Mediates Cholinergic Regulation of Keratinocyte Directional Migration

2005

The physiologic mechanisms that determine directionality of lateral migration are a subject of intense research. Galvanotropism in a direct current (DC) electric field represents a natural model of cell re-orientation toward the direction of future migration. Keratinocyte migration is regulated through both the nicotinic and muscarinic classes of acetylcholine (ACh) receptors. We sought to identify the signaling pathway mediating the cholinergic regulation of chemotaxis and galvanotropism. The pharmacologic and molecular modifiers of the Ras/Raf-1/MEK1/ERK signaling pathway altered both chemotaxis toward choline and galvanotropism toward the cathode in a similar way, indicating that the sam…

Biomimetic Alginate/Gelatin Cross-Linked Hydrogels Supplemented with Polyphosphate for Wound Healing Applications

2020

In the present study, the fabrication of a biomimetic wound dressing that mimics the extracellular matrix, consisting of a hydrogel matrix composed of non-oxidized and periodate-oxidized marine alginate, was prepared to which gelatin was bound via Schiff base formation. Into this alginate/oxidized-alginate-gelatin hydrogel, polyP was stably but reversibly integrated by ionic cross-linking with Zn2+ ions. Thereby, a soft hybrid material is obtained, consisting of a more rigid alginate scaffold and porous structures formed by the oxidized-alginate-gelatin hydrogel with ionically cross-linked polyP. Two forms of the Zn-polyP-containing matrices were obtained based on the property of polyP to f…

Child Protection in Mediterranean Countries: Italy and Greece

2023

Abstract This chapter explores the child protection systems in Italy and Greece. Both countries have to deal with immigrant children due to the conflict between the rights of minors and immigration laws on control and defense. In Italy, the child protection system is the result of a patchwork of norms and regulations addressing different societal demands and pressures. Family and cash-transfers are fundamental factors in Italy’s child welfare system. Greece, on the other hand, has adopted fragmented measures and policies connected with financial benefits, income support, social security, social care for disabled people, and rehabilitation for children at risk. The chapter also notes how the…

Model independent assertions for integration of heterogeneous schemas

1992

Due to the proliferation of database applications, the integration of existing databases into a distributed or federated system is one of the major challenges in responding to enterprises' information requirements. Some proposed integration techniques aim at providing database administrators (DBAs) with a view definition language they can use to build the desired integrated schema. These techniques leave to the DBA the responsibility of appropriately restructuring schema elements from existing local schemas and of solving inter-schema conflicts. This paper investigates the assertion-based approach, in which the DBA's action is limited to pointing out corresponding elements in the schemas an…

High-skilled migration and the knowledge society. Theories, processes, perspectives

2018

The recent economic crisis has led to an upswing in migration from the Mediterranean countries of Europe towards its central and northern development hubs. This overall increase in migration also includes high numbers of the so-called skilled migrants, consisting mainly, though not exclusively, of young people moving within Europe for study or specialisation, or seeking employment that matches their skills profile. It is no coincidence then that this new trend for skilled migration within Europe forms the main thrust of the cognitive and research interests of sociologists, economists and migration geographers. The aim of this paper is to reconstruct the theoretical debate on skilled migrati…

Społeczeństwo XXI wieku wobec zagrożenia islamskim terroryzmem

2018

Ylirajainen avioliitto: Puolisovalinta ja avioituminen Suomessa asuvien kurdien keskuudessa

2020

This study examines spousal choice and its gendered dimensions in the Kurdish diaspora, particularly among Kurds resident in Finland. The study focuses on a specific type of marriage migration; transnational marriage, in which migrants marry partners from their families´ homeland or from the same cultural or ethnic background within the diaspora. The research poses the following questions: What transnational courtship and marriages do Kurds resident in Finland enter into? Why do Kurds resident in Finland seek and marry a spouse transnationally? How do individuals and family members engage in negotiations for a suitable partner, in determining the compatibility criteria, and in tackling cult…

Pliocene colonization of the Mediterranean by Great White Shark inferred from fossil records, historical jaws, phylogeographic and divergence time an…

2020

Aim: Determine the evolutionary origin of the heretofore poorly characterized contemporary Great White Shark (GWS; Carcharodon carcharias) of the Mediterranean Sea, using phylogenetic and dispersal vicariance analyses to trace back its global palaeo-migration pattern. Location: Mediterranean Sea. Taxon: Carcharodon carcharias. Methods: We have built the largest mitochondrial DNA control region (CR) sequence dataset for the Mediterranean GWS from referenced historical jaws spanning the 19th and 20th centuries. Mediterranean and global GWS CR sequences were analysed for genetic diversity, phylogenetic relationships and divergence time. A Bayes factor approach was used to assess two scenarios …

Determinants of inter-regional migration in the Baltic countries

2003

We show that Estonia, Latvia and Lithuania despite small geographical size feature considerable and persistent regional disparities. Registered migration rates have declined dramatically since the last years of Soviet era, yet they are high by international standards. Evidence from regional inflows and outflows in Latvia and from Estonian labour force survey is used to show that regional unemployment and especially wage differentials, as well as demographic factors, have a significant impact both on gross and net migration flows. Age and education effects are consistent with predictions of the human capital model of migration. Unemployed persons, as well as commuters between regions, are si…