Search results for "Migration"
showing 10 items of 1709 documents
Three-dimensional invasion of human glioblastoma cells remains unchanged by X-ray and carbon ion irradiation in vitro.
2012
Purpose Cell invasion represents one of the major determinants that treatment has failed for patients suffering from glioblastoma. Contrary findings have been reported for cell migration upon exposure to ionizing radiation. Here, the migration and invasion capability of glioblastoma cells on and in collagen type I were evaluated upon irradiation with X-rays or carbon ions. Methods and Materials Migration on and invasion in collagen type I were evaluated in four established human glioblastoma cell lines exposed to either X-rays or carbon ions. Furthermore, clonogenic radiation survival, proliferation (5-bromo-2-deoxyuridine positivity), DNA double-strand breaks (γH2AX/53BP1-positive foci), a…
IAPs and cell migration.
2015
Inhibitors of apoptosis (IAPs) constitute a family of cell signaling regulators controlling several fundamental biological processes such as innate immunity, inflammation, cell death, cell proliferation, and cell differentiation. Increasing evidence from in vivo and in vitro studies indicate a function for IAPs in the modulation of invasive and migratory properties of cells. Here, we present and discuss the mechanisms whereby IAPs can control cell migration.
Science Signaling Podcast: 5 August 2014
2014
This Podcast features an interview with Juliane Mooz and Krishnaraj Rajalingam, authors of a Research Article that appears in the 5 August 2014 issue of Science Signaling , about the cellular functions of the kinase ARAF. RAF proteins are serine-threonine kinases that mediate signaling through the mitogen-activated protein kinase (MAPK) pathway, and aberrant RAF activity can transform normal cells into cancerous cells. There are three RAFs in mammals: ARAF, BRAF, and CRAF. The most studied of these is BRAF, mutations in which are associated with various cancers. Whereas the cellular functions of BRAF and CRAF have been extensively studied, not much is known about ARAF. Mooz et al . found th…
3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells
2014
Objective Growing evidences indicate that the histone methyltransferase EZH2 (enhancer of zeste homolog 2) may be an appropriate therapeutic target in some tumors. Indeed, a high expression of EZH2 is correlated with poor prognosis and metastasis in many cancers. In addition, 3-Deazaneplanocin A (DZNep), an S-adenosyl-L homocysteine hydrolase inhibitor which induces EZH2 protein depletion, leads to cell death in several cancers and tumors. The aim of this study was to determine whether an epigenetic therapy targeting EZH2 with DZNep may be also efficient to treat chondrosarcomas. Methods EZH2 expression was determined by immunohistochemistry and western-blot. Chondrosarcoma cell line CH2879…
The policy and politics of migrants and health: European view
2018
O que sabemos hoje, quais as lacunas na compreensão do problema e quais as perspetivas futuras? Nas últimas décadas, os países Europeus têm-se confrontado com um aumento dos fluxos migratórios, tornando a migração um fenómeno comum e em sociedades cada vez mais diversificadas. No contexto do processo migratório, as populações migrantes e refugiadas confrontam-se, no país de acolhimento, com um novo contexto social, cultural e linguístico. Por outro lado, a atual complexidade deste processo decorre, também, de uma população migrante heterogénea, com diferentes características e necessidades em saúde. A migração coloca importantes desafios para a saúde, relativamente aos determinantes sociais…
Consumo, risparmio, rimesse, Una proposta di analisi
2021
Recentemente è stato affrontato il tema dell'integrazione attraverso i consumi analizzando le strategie messe in atto da cittadini migranti che proprio attraverso l’assimilazione e la riproduzione degli stili di consumo del paese ospitante ricostituiscono, ricompongono o innovano una domanda identitaria culturale comunque percepita come un bisogno più che latente. Il saggio analizza le dinamiche di risparmio, consumo e rimesse dei cittadini migranti con una proposta di analisi Recently, the theme of integration through consumption has been addressed by analyzing the strategies implemented by migrant citizens who, precisely through the assimilation and reproduction of the host country's cons…
Maahanmuuttajien kotoutumiskokemukset Etelä-Pohjanmaan maaseutumaisille alueille
2012
Artikkeli tarkastelee maaseutumaisella alueella asuvien maahanmuuttajien kotoutumista useiden eri tekijöiden kautta. Tutkimuksessa on hyödynnetty sekä kvantitatiivista postikyselyä että kvalitatiivista teemahaastattelua. Kotoutumisesta piirtyvä kuva näyttää useimpien maahanmuuttajien kohdalla myönteiseltä. Erityisesti virolaisten tilanne on selvästi muita valoisampi: heidän suomen kielen taitonsa on muita ryhmiä parempi, ja he ovat työllistyneet ja onnistuneet vakauttamaan työmarkkina-asemaansa muita ryhmiä paremmin. Lisäksi heidän sosiaaliset verkostonsa ovat venäläisiin verrattuna monipuolisemmat. Virolaiset myös tuntevat olonsa muita ryhmiä useammin kotoisaksi Etelä-Pohjanmaalla. Venäläi…
Fiscal impact of the migration phenomenon
2019
Professor Dr Med Oskar Fehr: the fate of an outstanding German-Jewish ophthalmologist: an early contributor to cornea and external disease.
2014
PURPOSE The aim of this study was to recount the immense and abrupt change in the private and professional life of a prominent German-Jewish ophthalmologist in the transition from democracy to dictatorship in Germany during the first half of the 20th century. METHODS This involves a Retrospective analysis of Fehr's clinical and scientific work as the first assistant of Julius Hirschberg's world-famous eye clinic in Berlin; evaluation of Fehr's successful tenure as a chair of Virchow's Eye Hospital; the catastrophic influence of Hitler's seizure of power on the private and professional lives of German-Jewish physicians; and an analysis of Fehr's personal and professional will to continue the…
Inferring genetic connectivity in real populations, exemplified by coastal and oceanic atlantic cod
2018
Significance Estimates of migration are important for understanding the dynamics of natural populations. A statistic known as FST is often used to measure levels of genetic differentiation among natural populations. Equations that translate FST into estimates of migration are based on “ideal” populations, which are subject to many simplifying assumptions compared with real populations. Therefore, theoretical estimates of migration might not be realistic. We modeled populations of Atlantic cod in the North Sea and the adjacent Skagerrak region to compare how migration is related to the complexities of real populations, and how actual migration compares with predictions based on theory. Resul…