Search results for "Mine"
showing 10 items of 20410 documents
Chiral Serum Pharmacokinetics of 4-Fluoroamphetamine after Controlled Oral Administration
2021
Abstract Over the last two decades, misuse of 4-fluoroamphetamine (4-FA) became an emerging issue in many European countries. Stimulating effects last for 4–6 hours and can impact psychomotor performance. The metabolism of amphetamine-type stimulants is stereoselective and quantification of (R)- and (S)-enantiomers has been suggested for assessing time of use. To date, no data on enantioselective pharmacokinetics is available for 4-FA in serum samples. An enantioselective liquid chromatography−tandem mass spectrometry (LC–MS-MS) method was developed using a chiral Phenomenex® Lux 3 μm AMP column. Validation of the method showed satisfactory selectivity, sensitivity, linearity (0.5–250 ng/mL…
Diastereoselective synthesis of 6-functionalized 4-aryl-1,3-oxazinan-2-ones and their application in the synthesis of 3-aryl-1,3-aminoalcohols and 6-…
2010
Abstract Halocyclocarbamation of benzyl N -(1-phenyl-3-butenyl)carbamates afforded 6-functionalized 4-aryl-1,3-oxazinan-2-ones with moderate to excellent diastereoselectivity depending on the N -substituent. Importantly, in contrast to reported cyclocarbamations of homoallylic carbamates, which are generally trans -diastereoselective, cyclization of N -unsubstituted Cbz-protected homoallylamines led to cis -1,3-oxazinan-2-ones, predominantly. The use of N -benzylated and in situ prepared N -silylated derivatives resulted however in trans -selectivity. Transition states are proposed to explain the stereochemical influence of the N -substituent on the cyclocarbamations. The functionalized 1,3…
Konsten att vinna ett krig – och att förlora ett annat: fredens kriser efter trettioåriga kriget och stora nordiska kriget
2012
Smart inulin-based polycationic nanodevices for siRNA delivery
2017
The advances of short interfering RNA (siRNA) mediated therapy provide a powerful option for the treatment of many diseases by silencing the expression of targeted genes including cancer development and progression. Inulin is a very simple and biocompatible polysaccharide proposed by our groups to produce interesting delivery systems for Nucleic Acid Based Drugs (NABDs), such as siRNA, either as polycations able to give polyplexes and polymeric coatings for nanosystems having a metallic core. In this research field, different functionalizing groups were linked to the inulin backbone with specific aims including oligoamine such as Ethylendiammine (EDA), Diethylediamine (DETA), Spermine, (SPM…
Development of a simple, biocompatible and cost-effective Inulin-Diethylenetriamine based siRNA delivery system
2015
Small interfering RNAs (siRNAs) have the potential to be of therapeutic value for many human diseases. So far, however, a serious obstacle to their therapeutic use is represented by the absence of appropriate delivery systems able to protect them from degradation and to allow an efficient cellular uptake. In this work we developed a siRNA delivery system based on inulin (Inu), an abundant and natural polysaccharide. Inu was functionalized via the conjugation with diethylenetriamine (DETA) residues to form the complex Inu-DETA. We studied the size, surface charge and the shape of the Inu-DETA/siRNA complexes; additionally, the cytotoxicity, the silencing efficacy and the cell uptake-mechanis…
Lämpösähköisen materiaalin lämmönjohtavuuden määrittäminen matalissa lämpötiloissa käyttäen 3ω-menetelmää
2014
Työssä tutkittiin mittausmenetelmää lämmönjohtavuuden määrittämiseen mata- lissa lämpötiloissa. Mittaukset perustuivat 3ω menetelmään, joka on alunperin ohut- kalvoille kehitetty menetelmä lämmönjohtavuuden mittaukseen. Menetelmässä läm- mitinlangan läpi kulkeva vaihtovirta synnyttää kolminkertaisella taajudella olevan jännitteen, jonka avulla saadaan tietoa kappaleen termisistä ominaisuuksista. Mit- tauksissa kultainen lämmitinlanka höyrystettiin Kapton kalvon päälle ja tämän päälle hyvin ohut alumiinioksidikerros. Mittaukset suoritettiin pulssituubijäähdyttimeen ra- kennetussa näytteenpitimessä. Laitteiston toiminta varmistettiin huoneenlämpötilas- sa borosilikaatti- ja Kapton näytteillä.…
CCDC 173857: Experimental Crystal Structure Determination
2002
Related Article: G.Rajsekhar, C.P.Rao, P.K.Saarenketo, E.Kolehmainen, K.Rissanen|2002|Carbohydr.Res.|337|187|doi:10.1016/S0008-6215(01)00311-1
CCDC 2012793: Experimental Crystal Structure Determination
2020
Related Article: William J. Robinson, Annie E. Taylor, Solange Lauga-Cami, George W. Weaver, Randolph R.J. Arroo, Marcel Kaiser, Sheraz Gul, Maria Kuzikov, Bernhard Ellinger, Kuldip Singh, Tanja Schirmeister, Adolfo Botana, Chatchakorn Eurtivong, Avninder S. Bhambra|2021|Eur.J.Med.Chem.|209|112871|doi:10.1016/j.ejmech.2020.112871
CCDC 872438: Experimental Crystal Structure Determination
2012
Related Article: B.Abu Thaher, P.Koch, D.Schollmeyer, S.Laufer|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o632|doi:10.1107/S1600536812004096
Case study on teachers’ contribution to children’s participation in Finnish preschool classrooms during structured learning sessions
2013
The main aim of this study was to identify different teaching practices and explore the types of opportunities that they provide for children’s participation in four different Finnish preschool classrooms for 6-year olds during structured learning sessions. Observational data of four preschool teachers were analyzed according to the principles of qualitative content analysis. Three themes of teachers’ practices were identified, which described the key practices through which teachers influence children’s participation, namely, through discussion and conversations; by referring to shared rules and managing the classroom; and through demonstrating pedagogical sensitivity and understanding tow…