Search results for "Minot"

The Natural Fungal Metabolite Beauvericin Exerts Anticancer Activity In Vivo: A Pre-Clinical Pilot Study

2017

Recently, in vitro anti-cancer properties of beauvericin, a fungal metabolite were shown in various cancer cell lines. In this study, we assessed the specificity of this effect by comparing beauvericin cytotoxicity in malignant versus non-malignant cells. Moreover, we tested in vivo anticancer effects of beauvericin by treating BALB/c and CB-17/SCID mice bearing murine CT-26 or human KB-3-1-grafted tumors, respectively. Tumor size and weight were measured and histological sections were evaluated by Ki-67 and H/E staining as well as TdT-mediated-dUTP-nick-end (TUNEL) labeling. Beauvericin levels were determined in various tissues and body fluids by LC-MS/MS. In addition to a more pronounced …

Aspartate aminotransferase in brain tissue cultures

1969

La syndicalisation des cheminots français. Fin ou résistance d’un « bastion ».

2013

International audience; Sans revenir sur les évolutions de la syndicalisation – tant en France ou, plus globalement, en Europe –, ni sur ses analyses, il apparaît que celle-ci aurait assez bien résisté dans le secteur ferroviaire, souvent présenté, dans le cas français à tout le moins, comme une sorte de « bastion » syndical, lequel est également invoqué pour expliquer la « combativité » des cheminots.On peut naturellement supposer que cette plus forte propension à « se mobiliser » est liée notamment à un niveau d’engagement syndical – notamment dans des organisations contestataires – qui resterait beaucoup plus élevé que dans les autres secteurs de l’économie. Ce n’est sans aucun doute pas…

Nephrotoxic and hepatotoxic effects of chromium compounds in rats

1986

The nephrotoxic, hepatotoxic and cardiotoxic actions of hexavalent chromium compounds, as well as their effects on lung, blood and circulation may contribute to the fatal outcome of chromium intoxication. Although trivalent chromium have been regarded as relatively biologically inert, there are a few salts of chromium III that have been found to be carcinogenic when inhaled, ingested or brought in contact with the tissues. Sensitive persons and industry workers have been subjects of dermatitis, respiratory tract injuries and digestive ulcers due to chromium compounds. In this work, the authors have studied the effect of trivalent and hexavalent chromium compounds on rats measuring the trans…

Quelle "citoyenneté industrielle" à la SNCF ? Premiers éléments

2019

International audience; Dans un contexte de transformation des règles de représentation syndicale et de la négociation collective, de reconfiguration des institutions représentatives du personnel, d’évolutions et de débats concernant la participation de représentants des salariés au sein des conseils d’administration et, plus au fond, d’évolution de la sociologie et du débat syndical mais aussi de réformes ferroviaires récurrentes, touchant notamment au statut du personnel, il est proposé d’examiner comment dans une entreprise, telle la SNCF, certains acteurs – en l’occurrence les organisations syndicales – mais aussi le (célèbre) « statut » du personnel appréhendent (ou pas) cette notion d…

Tissue Sparing Posterior Cervical Indirect Decompression and Fusion in Foraminal Stenosis

2016

Treatment for patients with cervical foraminal stenosis that present with cervical radiculopathy has experienced rapid progress. Cervical spine surgical options have improved through advances in imaging, instrumentation, implant innovations and novel surgical techniques. While historical treatments are largely safe, comorbidities associated with procedures such as ACDF, TDR, and posterior foraminotomy beg the question if these procedures are too much surgery for select patients that could benefit from a tissue sparing approach. This chapter will introduce a novel, less disruptive surgical technique for achieving indirect decompression and fusion utilizing an intervertebral cervical implant.…

Serum ferritin is a discriminant marker for both fibrosis and inflammation in histologically proven non-alcoholic fatty liver disease patients

2011

INTRODUCTION: Differentiation between steatosis and non-alcoholic steatohepatitis (NASH) in non-alcoholic fatty liver disease (NAFLD) is important as NASH progress to cirrhosis. No specific laboratory/imaging technique exists either to diagnose NASH or to select patients for liver biopsy. PATIENTS AND METHODS: We evaluated serum ferritin and the features of metabolic syndrome with respect to histological inflammation and/or fibrosis in NAFLD patients. The Kleiner scoring system was used to classify NAFLD in consecutive liver biopsies. One hundred and eleven patients: median age 52.6, 64 males, obesity 62, diabetes mellitus (DM) 58, arterial hypertension 26 and hyperlipidaemia 40%. RESULTS: …

Early changes in dynamic biomarkers of liver fibrosis in hepatitis C virus-infected patients treated with sofosbuvir

2016

Abstract Background Chronic hepatitis C is a major cause of liver-associated mortality caused by decompensated cirrhosis and hepatocellular carcinoma. With the approval of sofosbuvir, therapeutic efficacy has markedly increased. Early changes in non-invasive biomarkers of liver fibrosis under effective antiviral therapy are widely unknown. Aim To evaluate early changes of fibrosis markers determined by enhanced liver fibrosis (ELF) scores and liver stiffness measurement (FibroScan®) in patients treated with sofosbuvir. Methods A total of 32 hepatitis C patients treated prospectively with sofosbuvir were included. The ELF-panel and FibroScan measurements were performed at baseline, week 4, e…

Serological Tests Do Not Predict Residual Fibrosis in Hepatitis C Cirrhotics with a Sustained Virological Response to Interferon

2016

BACKGROUND AND AIM: Liver biopsy (LB) has lost popularity to stage liver fibrosis in the era of highly effective anti-hepatitis C virus (HCV) therapy, yet diagnosis of persistent cirrhosis may have important implications following HCV eradication. As performance of serological non-invasive tests (NITs) to predict residual fibrosis in non-viremic HCV patients is unknown, we investigated accuracy of NITs to predict residual fibrosis in cirrhotics after a sustained virological response (SVR) to interferon (IFN). METHODS: Thirty-eight patients with a pre-treatment histological diagnosis of cirrhosis and a 48–104 months post-SVR LB were tested with APRI, CDS, FIB-4, FibroQ, Forns Score, GUCI Ind…

Impact of Obesity and Alanine Aminotransferase Levels on the Diagnostic Accuracy for Advanced Liver Fibrosis of Noninvasive Tools in Patients with No…

2019

Some evidence suggests an interference of obesity and alanine aminotransferase (ALT) levels on the diagnostic accuracy for advanced fibrosis of noninvasive tools such as liver stiffness measurement (LSM) by FibroScan, Fibrosis-4 (FIB-4), and nonalcoholic fatty liver disease fibrosis score (NFS). We assessed whether the diagnostic accuracy of LSM, Fibrosis-4 (FIB-4), and NFS and strategies based on the combination of these tools is affected by obesity and/or ALT levels.METHODS:We analyzed data from 968 patients with a histological diagnosis of nonalcoholic fatty liver disease. FIB-4, NFS, and LSM by FibroScan were measured.RESULTS:LSM was better than both FIB-4 and NFS for staging F3-F4 fibr…