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RESEARCH PRODUCT
Nephrotoxic and hepatotoxic effects of chromium compounds in rats
A. NúñezJ. Díaz-mayansR Labordasubject
Chromiuminorganic chemicalsTime FactorsChromium CompoundsHealth Toxicology and Mutagenesischemistry.chemical_elementPharmacologyToxicologyNephrotoxicitychemistry.chemical_compoundChromiumotorhinolaryngologic diseasesAnimalsUreaAspartate AminotransferasesHexavalent chromiumCarcinogenCreatininetechnology industry and agricultureAlanine TransaminaseRats Inbred StrainsGeneral MedicinePollutionRatschemistryBiochemistryBlood chemistryCreatinineKidney DiseasesChromium toxicityChemical and Drug Induced Liver Injurydescription
The nephrotoxic, hepatotoxic and cardiotoxic actions of hexavalent chromium compounds, as well as their effects on lung, blood and circulation may contribute to the fatal outcome of chromium intoxication. Although trivalent chromium have been regarded as relatively biologically inert, there are a few salts of chromium III that have been found to be carcinogenic when inhaled, ingested or brought in contact with the tissues. Sensitive persons and industry workers have been subjects of dermatitis, respiratory tract injuries and digestive ulcers due to chromium compounds. In this work, the authors have studied the effect of trivalent and hexavalent chromium compounds on rats measuring the transaminases (GOT and GPT), urea and creatinine levels in serum of chromium poisoned animals at different times.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1986-03-01 | Bulletin of Environmental Contamination and Toxicology |