Search results for "Mir"
showing 10 items of 1117 documents
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
2022
Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without effective late-stage treatment, since N-acetyl cysteine must be administered 8 h after overdose to be efficient. Ammonia homeostasis is altered during liver diseases and, during DILI, it is accompanied by decreased glycine N-methyltransferase (GNMT) expression and S-adenosylmethionine (AdoMet) levels that suggest a reduced methionine cycle. Anti-miR-873-5p treatment prevents cell death in primary hepatocytes and the appearance of necrotic areas in liver from APAP-adminis…
The Modifying Mirror
2023
Abstract This chapter compares music listening with the infant’s experience of care. Several scholars have argued that music can be used for scaffolding one’s self-experience. Developmental psychologists, in turn, maintain a wide consensus over the claim that, in early interaction, the attuned caregiver supports and modifies the infant’s self-experience in various ways. The chapter brings these phenomena together, illustrating how the examination of the early self/other relation can teach us something important concerning the listener/music relation. The first section elaborates on the scaffolding function of music and clarifies two ambiguities haunting the debate. The second section reloca…
Spectroscopic signatures for planar equilibrium geometries in methyl-substituted oligothiophenes
2009
In recent studies it was demonstrated that temperature-dependent optical spectroscopy is a valuable tool for revealing the differences in the geometries of flexible molecules like oligothiophenes (OTs) in the ground (S0) and first excited (S1) electronic states, by examining the symmetry relations between the absorption and emission spectra: while at low temperature the spectra show mirror symmetry, pointing to planar geometries in S0 and S1, the symmetry relation breaks down at ambient temperature due to thermal population of torsional modes. In the present joint spectroscopic and theoretical study, we demonstrate that this behavior is also observed for di- and tetramethyl-substituted OTs,…
radioterapia para el tratamiento del cáncer en la publicidad de principios del s. XX
2021
El descubrimiento de los rayos X y del radium generó gran curiosidad entre los científicos. Ambos elementos representaban la cura milagrosa que podría tratar una amplia gama de enfermedades mortales, como el cáncer, pudiendo llegar a colmar las expectativas de la población. El objetivo de dicho artículo es analizar las inserciones publicitarias relativas al radium y los rayos X aplicadas para el tratamiento del cáncer, en la prensa española a comienzos del siglo XX (1903-1912), en los periódicos ABC y La Vanguardia. Para ello, a partir de la hemeroteca digital de ambos medios se seleccionaron todas y cada una de las veces que se pudo identificar el término “cáncer” en los anuncios publicita…
Distribution, ecology and conservation status of Dionysia involucrata Zaprjag., an endangered endemic of Hissar Mts (Tajikistan, Middle Asia)
2014
<em>Dionysia involucrata</em> Zaprjag. (Primulaceae) is known as critically endangered endemic species of Hissar Mountains in Tajikistan. It is reported from few localities mainly in Varzob River valley and its tributaries. The species inhabits steep or overhanging faces of granite rocks in narrow river gorges. During the research all known populations of <em>D. involucrata</em> were examined in respect of the habitat conditions and species composition of vegetation plots. We analyzed the population extent of the species in its range in Tajikistan and the main threats in order to assess its conservation status. The detrended correspondence analysis was performed on a…
Piepju Aphyllophorales daudzveidību ietekmējošie faktori uz atmirušās koksnes egļu mežos
2015
Pētījuma mērķis ir noskaidrot, kāda ir piepju sugu daudzveidība uz atmirušās koksnes, atkarībā no koksnes sadalīšanās pakāpes, diametra, garuma, vecuma un kritalu attāluma virs zemes, egļu mežu teritorijās. Ierīkoti 14 parauglaukumi aizsargājamā teritorijā un arī saimnieciskos mežos. Noteikta atmirušās koksnes sadalīšanās pakāpe, diametrs, garums, vecums un kritalu attālums virs zemes egles, bērza un apses koksnei, noteikta piepju sugu daudzveidība. Pētījuma galvenie secinājumi: lielākā sugu daudzveidība konstatēta uz egļu kritalām otrajā sadalīšanās pakāpē; piepju sugu daudzveidība ir atkarīga no sadalīšanās pakāpes, diametra, garuma un kritalu attāluma virs zemes; neapstiprinājās tas, ka …
La politique sportive des Emirats du Golfe : comment obtenir une visibilité internationale ?
2006
Les petits Emirats du Golfe Persique ont choisi le sport pour obtenir une visibilité internationale et modifier leur image. Le sport offrait la possibilité d’afficher une modernité souvent associée à l’adoption de valeurs venues de l’Occident. Sans traditions sportives et très peu peuplés, ces Etats ont néanmoins réussi leur entrée sur la scène sportive internationale en mobilisant beaucoup d’argent. Ils ont pu ainsi accueillir et organiser des compétitions sportives internationales de grande ampleur et se faire reconnaître. Leur politique a franchi un nouveau pas, depuis quatre années, en naturalisant des athlètes de haut niveau pour obtenir des médailles car en terme de communication, l’i…
Serum miRNAs in women affected by hyperandrogenic polycystic ovary syndrome: the potential role of miR-155 as a biomarker for monitoring the estropro…
2018
MicroRNAs can be used as very efficient circulating biomarkers. The role of microRNAs in polycystic ovary syndrome (PCOS) and the effects of antiandrogen therapy on microRNA expression is still not fully understood. A panel of serum microRNAs were retrotranscribed via looped reverse primer transcription specific for each miRNA and quantified via probe specific RT-PCR in 16 Caucasian hyperandrogenic PCOS women selected according to the Rotterdam criteria and in a subset of seven patients after four months of sequential reverse antiandrogenic therapy. All women recruited underwent an oral glucose tolerance test (OGTT) and a baseline total cholesterol, high density lipoproteins cholesterol, tr…
miR-31-5p Is a LIPUS-Mechanosensitive MicroRNA that Targets HIF-1α Signaling and Cytoskeletal Proteins
2019
The roles of low-intensity pulsed ultrasound (LIPUS) and microRNAs (miRNAs) on hMSCs commitments have already been investigated
Prognostic and Functional Significant of Heat Shock Proteins (HSPs) in Breast Cancer Unveiled by Multi-Omics Approaches
2021
Simple Summary In this study, we investigated the expression pattern and prognostic significance of the heat shock proteins (HSPs) family members in breast cancer (BC) by using several bioinformatics tools and proteomics investigations. Our results demonstrated that, collectively, HSPs were deregulated in BC, acting as both oncogene and onco-suppressor genes. In particular, two different HSP-clusters were significantly associated with a poor or good prognosis. Interestingly, the HSPs deregulation impacted gene expression and miRNAs regulation that, in turn, affected important biological pathways involved in cell cycle, DNA replication, and receptors-mediated signaling. Finally, the proteomi…