Search results for "Misa"

Telmisartan as metabolic modulator: a new perspective in sports doping?

2011

The World Antidoping Agency (WADA) has introduced some changes in the 2012 prohibited list. Among the leading innovations to the rules are that both 5-aminoimidazole-4-carboxamide-1-[beta]-D-ribofuranoside (peroxisome proliferator�activated receptor-[delta] [PPAR-[delta]]-5' adenosine monophosphate-activated protein kinase [AMPK] agonist) and GW1516 (PPAR-[delta]-agonist) are no longer categorized as gene doping substances in the new 2012 prohibited list but as metabolic modulators in the class �Hormone and metabolic modulators.� This may also be valid for the angotensin II receptor blocker telmisartan. It has recently been shown that telmisartan might induce similar biochemical, biological…

Shock control bump design optimization on natural laminar aerofoil

2011

The chapter investigates Shock Control Bumps (SCB) on a Natural Laminar Flow (NLF) aerofoil; RAE 5243 for Active Flow Control (AFC). A SCB approach is used to decelerate supersonic flow on the suction/pressure sides of transonic aerofoil that leads delaying shock occurrence or weakening of shock strength. Such an AFC technique reduces significantly the total drag at transonic speeds. This chapter considers the SCB shape design optimisation at two boundary layer transition positions (0 and 45%) using an Euler software coupled with viscous boundary layer effects and robust Evolutionary Algorithms (EAs). The optimisation method is based on a canonical Evolution Strategy (ES) algorithm and inco…

Evolutionary Algorithms and Metaheuristics : Applications in Engineering Design and Optimization

2018

The use of artificial intelligence techniques to optimise and control injection moulding processes

1999

In the paper a typical injection moulding process on a single-screw extrusion machine aimed to the production of axisymmetric polypropylene dishes for alimentary use has been investigated. First of all the most important process parameters have been individuated; subsequently a wide testing hyperspace has been investigated, at varying the process parameters in a large range. For each combination both some geometrical characteristics of the obtained component have been measured and the occurrence of defects has been verified. The largest part of the available data have been used to train a neural network aimed to explain the process dynamics. Furthermore an offline control system, based on f…

Optimisation of Heat Loss through Ventilation for Residential Buildings

2018

This study presents the results of research on heat loss from various types of residential buildings through ventilation systems. Experimental research was done to analyse the effectiveness of ventilation systems of different types and determine the parameters of air discharged via the ventilation ducts. A model of heat loss from the discharge of exhaust air outside through air ducts has since been developed. Experiments were conducted on three experimental systems of building ventilation: gravitational, mechanical, and supply-exhaust ventilation systems with heat recovery. The proposed model dependencies were used to chart the daily fluctuations of the optimum multiplicity of air exchange …

Influences of atomization process and precursor material on the compaction mechanisms and metallurgical properties of parts developed by HIP

2022

Hot Isostatic pressing process is based on the densification of metals powders to near net shape parts with higher mechanicals properties than forged chemical equivalent. The precursor material can influence the parts properties. Thus the aims of this these is to understand the influence of the powder properties on the HIP parts. The particles characterization and the elements and compound monitoring during the HIP cycle allowed to understand the different oxidations phenomenons and their impact on the mechanical properties of parts. The comparison of differents powders batches with identical particles size repartition or identical chemical composition showed that the chemical composition a…

MULTI-OBJECTIVE OPTIMISATION OF BUILDINGS AND BUILDING CLUSTERS PERFORMANCE: A LIFE CYCLE THINKING APPROACH

2021

Cone-beam computed tomography and its applications in dental and maxillofacial radiology.

2020

Cone-beam computed tomography (CBCT) was first used in dental and maxillofacial radiology (DMFR) at the end of the 1990s. Since then, it has been successfully established as the standard three-dimensional radiographic imaging technique in DMFR, with a wide variety of applications in this field. This manuscript briefly reviews the background information on the technology and summarises available data on effective dose and dose optimisation. In addition, typical clinical applications and indications of the technique in DMFR are presented.

Sexual Exploitation in the Destination Country

2020

When the vulnerability of Nigerian and Romanian women in human trafficking is concerned, it is not only important to understand the causes that led the victim into a situation of trafficking, but also to understand the factors that maintain the individual in a situation of victimisation. However, this does not mean that these factors are separated according to the different phases of trafficking. On the contrary, it demonstrates that the accumulation of different factors can generate a higher or lower level of vulnerability, as well as the balance of factors affecting the women during the different phases. Therefore, in this chapter I will put forward a general analysis of the different fac…

AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats.

2008

Several enzymatic sources of reactive oxygen species (ROS) were described as potential reasons of eNOS uncoupling in diabetes mellitus. In the present study, we investigated the effects of AT1-receptor blockade with chronic telmisartan (25 mg/kg/day, 6.5 weeks) therapy on expression of the BH4-synthesizing enzyme GTP-cyclohydrolase I (GCH-I), eNOS uncoupling, and endothelial dysfunction in streptozotocin (STZ, 60 mg/kg iv, 7 weeks)-induced diabetes mellitus (type I). Telmisartan therapy did not modify blood glucose and body weight. Aortas from diabetic animals had vascular dysfunction as revealed by isometric tension studies (acetylcholine and nitroglycerin potency). Vascular and cardiac RO…