Search results for "Mito"
showing 10 items of 2513 documents
eIF2α confers cellular tolerance to S. aureus α-toxin
2015
We report on the role of conserved stress-response pathways for cellular tolerance to a pore forming toxin. First, we observed that small molecular weight inhibitors including of eIF2α-phosphatase, jun-N-terminal kinase (JNK), and PI3-kinase sensitized normal mouse embryonal fibroblasts (MEFs) to the small pore forming S. aureus α-toxin. Sensitization depended on expression of mADAM10, the murine ortholog of a proposed high-affinity receptor for α-toxin in human cells. Similarly, eIF2α (S51A/S51A) MEFs, which harbor an Ala knock-in mutation at the regulated Ser51 phosphorylation site of eukaryotic translation initiation factor 2α, were hyper-sensitive to α-toxin. Inhibition of translation w…
Il mito delle origini spagnole della camorra, tra letteratura e storia
2015
Dalle prime fonti post-unitarie agli scritti di metà Novecento e di fine millennio, le origini dell’organizzazione criminale campana sono state spesso messe in relazione, più o meno diretta e quasi sempre con il ricorso ad argomenti etimologici, con il passato vicereale di Napoli, una delle principali metropoli dell’Europa moderna. L’epoca spagnola, secondo uno stereotipo di lunga durata, viene vista come ideale modello storico negativo, ma anche come luogo mitico che intreccia memorie e leggende di ascendenza folclorica in cui poter situare i natali, più o meno nobili, di un fenomeno criminale che fin da subito ha dato luogo a una sua propria tradizione letteraria.
La historia entre verdades 'discutibles' y mercado de las noticias
2015
En un contexto cultural en el que los temas históricos se han convertido en una simple mercancía, Italia es además un interesante ejemplo de uso político de la Historia con una ambiciosa finalidad estratégica de dimensión europea: volver a definir la legitimidad de las grandes transformaciones de la edad contemporánea, especialmente, las que van desde la Revolución francesa, a la Revolución de Octubre, hasta el movimiento de Resistencia antifascista. En este sentido, la obra del historiador Renzo de Felice sigue siendo objeto de debate y punto de partida de una constante discusión ideológica. In a cultural context in which historical matters have become a simple merchandise, Italy is also …
El mite de la terra alta
2011
La identificació del camp amb la genuïnitat no és exclusiva de la cultura catalana. L’article analitza la construcció d’aquest mite en la literatura catalana del segle xix, prestant particular atenció a la derivació patriòtica que uneix paisatge, habitants i tradicions rurals amb la Catalunya real que lentament anava desapareixent com a resultat de les revolucions polítiques i industrials. El mite de la terra alta ha proporcionat símbols tan freqüentment utilitzats com ara el de la barretina (un tipus de capell) i la muntanya, així com alguns debats ben interessants sobre l’organització tradicional de la família i els contrastos entre camp-ciutat i tradició-revolució.
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.
2015
The NG2 proteoglycan is characteristically expressed by oligodendrocyte progenitor cells (OPC) and also by aggressive brain tumours highly resistant to chemo- and radiation therapy. Oligodendrocyte-lineage cells are particularly sensitive to stress resulting in cell death in white matter after hypoxic or ischemic insults of premature infants and destruction of OPC in some types of Multiple Sclerosis lesions. Here we show that the NG2 proteoglycan binds OMI/HtrA2, a mitochondrial serine protease which is released from damaged mitochondria into the cytosol in response to stress. In the cytosol, OMI/HtrA2 initiates apoptosis by proteolytic degradation of anti-apoptotic factors. OPC in which NG…
Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues
2019
Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin resistance in which oxidative stress is thought to be a primary cause. Considering that mitochondria are the main source of ROS, we have set out to provide a general overview on how oxidative stress is generated and related to T2D. Enhanced generation of reactive oxygen species (ROS) and oxidative stress occurs in mitochondria as a consequence of an overload of glucose and oxidative phosphorylation. Endoplasmic reticulum (ER) stress plays an important role in oxidative stress, as it is also a source of ROS. The tight interconnection between both organelles through mitochondrial-associated membranes (MAM…
Retracted: Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders.
2019
Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. …
Dal Mythos al Logos. Genealogia della Pedagogical Turn
2013
It is possible to identify an original pedagogical turn starting from classical world, when the theoretical thinking and the organization of a shared public space involve in the constitution of pedagogical science, which must found an educational model useful in the new theoretical and political context. The turning point is located in the devaluation of religious-mythical education, thinking image as false, and in the founding of the paradigm of identity, based on word as true.
Reinos de amazonas en la literatura española de la Edad Media y los Siglos de Oro: arquetipos, género y alteridad
2017
En este trabajo de tesis nos proponemos el estudio crítico –diacrónico– del tratamiento que se ha venido dando a lo largo de la historia de la literatura al tema de las Amazonas, el legendario grupo de exóticas guerreras que constituían un estado totalmente separado de los hombres El estado de la cuestión, así como las respuestas que se pueden ofrecer desde la perspectiva de los estudios de género, la literatura comparada y la crítica literaria, es lo que tratamos de abordar en el capítulo 1, bajo el epígrafe “Reinos de amazonas: crítica, género y alteridad”. Nuestro trabajo –sobre las bases de los estudios históricos, mitológicos y mitocríticos, de teoría de género, de estudios culturales …
Prometeo genetista. Profitti delle tecniche e metafore della scienza
2016
Il saggio di Claude Calame affronta una tematica di grande rilievo scientifico, ossia il confronto tra il valore epistemologico e sociale dell'uso delle arti tecniche nell'antica Grecia e il valore epistemologico del linguaggio della scienza moderna in particolare applicato all'ambito della genetica e delle moderne biotecnologie e scienze di laboratorio. Lo spunto del confronto è offerto dall'analisi storico-culturale e antropologica del mito di Prometeo, come è stato diversamente declinato dai vari autori dell'antichità classica, a partire da Esiodo sino a Platone, passando per l'autore del dramma "Prometeo incatenato". In una prospettiva di indagine antropopoietica, le arti tecniche perme…