Search results for "Mito"
showing 10 items of 2513 documents
Divergent Distribution in Vascular and Avascular Mammalian Retinae Links Neuroglobin to Cellular Respiration
2005
The visual function of the vertebrate retina relies on sufficient supply with oxygen. Neuroglobin is a respiratory protein thought to play an essential role in oxygen homeostasis of neuronal cells. For further understanding of its function, we compared the distribution of neuroglobin and mitochondria in both vascular and avascular mammalian retinae. In the vascular retinae of mouse and rat, oxygen is supplied by the outer choroidal, deep retinal, and inner capillaries. We show that in this type of retina, mitochondria are concentrated in the inner segments of photoreceptor cells, the outer and the inner plexiform layers, and the ganglion cell layer. These are the same regions in which oxyge…
Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms.
2019
Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restriction endonuclease (mtEcoBI) results in unexpected metabolic reprogramming in adult flies, distinct from effects on OXPHOS. Carbohydrate utilization was repressed, with catabolism shifted towards lipid oxidation, accompanied by elevated serine synthesis. Cleavage and translocation, the two modes of mtEcoBI action, repressed carbohydrate rmetabolism via two different mechanisms. DNA cleavage activ…
A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice
2020
We previously observed an unexpected fivefold (35 vs. 200 days) difference in the survival of respiratory chain complex III (CIII) deficient Bcs1lp.S78G mice between two congenic backgrounds. Here, we identify a spontaneous homoplasmic mtDNA variant (m.G14904A, mt-Cybp.D254N), affecting the CIII subunit cytochrome b (MT-CYB), in the background with short survival. We utilize maternal inheritance of mtDNA to confirm this as the causative variant and show that it further decreases the low CIII activity in Bcs1lp.S78G tissues to below survival threshold by 35 days of age. Molecular dynamics simulations predict D254N to restrict the flexibility of MT-CYB ef loop, potentially affecting RISP dyna…
The Many Souls of Dallapiccola's "Ulysses"
2009
L'"Ulisse" di Dallapiccola somma esperienze letterarie molto diverse tra loro. Somma inoltre alla rivisitazione di un mito complesso e stratificato, l'ambizione di ridare vita a un genere, quello operistico, che sembra aver concluso il suo percorso. Somma infine nel protagonista le caratteristiche dell'astuto personaggio di Omero e di quello curioso e inappagato di Dante. Ma non solo: l'Ulisse di Dallapiccola aggiunge a queste il dubbio, l'incertezza, l'interrogare e l'interrogarsi che ne fanno un cittadino della modernità. E in questa veste, passando per l'immagine di Cristoforo Colombo, impersona colui che fu capace di mostrare al compositore "un altro Nord", il suo grande maestro, Arnold…
Transglutaminase and polyamine dependence of effector functions of human immunocompetent cells
1982
AbstractThe effects of the transglutaminase inhibitor dansyl cadaverine (DC) and the polyamine antagonist methyl glyoxal-bis-(guanylhydrazone) (MeGbG) on the response of lymphocytes towards allogeneic and lectin stimulation and on the zymosan-induced chemiluminescence of neutrophilic granulocytes was studied. Application of DC resulted in dose-dependent suppression of chemiluminiscence and lymphocyte proliferation; no difference of inhibitory potential occurred with variation of incubation time in the latter system. MeGbG was inactive in granulocytes, but inhibited lymphocyte proliferation; its effect increased with time. The experiments provide further evidence for the importance of transg…
Kopmītņu pārvaldības sistēma
2019
Kvalifikācijas darbs ”Kopmītņu pārvaldības sistēma” apraksta tīmekļa sistēmu, kas ir paredzēta kopmītņu pārvaldības optimizēšanai un vadības, un iemītnieku pienākumu atvieglošanai. “Kopmītņu pārvaldības sistēma” ietver funkcijas istabu pārvaldīšanai, iedzīvotāju pārvaldībai, kā arī iedzīvotāju un pārvaldības saziņai. Lietotāji ir sadalīti tipos, un tipiem ir pieejamas funkcijas, kas attiecas uz to lomu sistēmā. Izmantojot šo sistēmu, kopmītņu vadība un strādnieki var efektīvi pārvaldīt iedzīvotājus un to istabas, atbildēt un rīkoties pēc iedzīvotāju pieteikumiem, un iedzīvotāji var ērti sazināties ar citiem īrniekiem, vadību, un izmantot kopmītņu resursus. Kopmītņu darbinieki var izmantot s…
El mito de la historia del arte
2005
Reflexiones sobre la creación del mito de la Historia del Arte, es decir la conversión de la experiencia artística en reflexión histórica e ideológica. El desarrollo de esta disciplina se lleva a cabo a partir de un concepto tomado de la religión: el canon. Se verá también la manera cómo el arte convertido en religión, promueve la aparición de la disciplina que se encargará de crear el cuerpo de creencias necesarias para el mantenimiento de esta religión, y la serie sucesiva de impugnaciones que genera. (A)
The fine structure of denervated and reinnervated muscle spindles: morphometric study of intrafusal muscle fibers.
1979
The fine structure of normal, denervated, and reinnervated muscle spindles in lower lumbrical muscles of rats was studied morphometrically at time intervals ranging from 3-14 months. In control spindles, the mean transverse area of mitochondria was estimated to be more than twice as large in nuclear chain than in typical nuclear bag fibers. Following denervation, there was a severe decrease of the mean number and transverse area of mitochondria, and a moderate, but statistically significant decrease of the mean transverse area of intrafusal muscle fibers (IMFs) despite an increase of the number of IMFs. At 12-14 months of reinnervation, changes of the transverse areas of IMFs were statistic…
Cytotoxic Activity of Organotin(IV) Derivatives with Triazolopyrimidine Containing Exocyclic Oxygen Atoms
2020
In this study cytotoxicity of organotin(IV) compounds with 1,2,4-triazolo[1,5-a]pyrimidines, Me3Sn(5tpO) (1), n-Bu3Sn(5tpO) (2), Me3Sn(mtpO) (3), n-Bu3Sn(mtpO) (4), n-Bu3Sn(HtpO2) (5), Ph3Sn(HtpO2) (6) where 5HtpO = 4,5-dihydro-5-oxo-[1,2,4]triazolo-[1,5-a]pyrimidine, HmtpO = 4,7-dihydro-5-methyl-7-oxo-[1,2,4]triazolo-[1,5-a]pyrimidine, and H2tpO2 = 4,5,6,7-tetrahydro-5,7- dioxo-[1,2,4]triazolo-[1,5-a]-pyrimidine, was assessed on three different human tumor cell lines: HCT-116 (colorectal carcinoma), HepG2 (hepatocarcinoma) and MCF-7 (breast cancer). While 1 and 3 were inactive, compounds 2, 4, 5 and 6 inhibited the growth of the three tumor cell lines with IC50 values in the submicromolar …
Введение въ исторію бородатыхъ карликообразныхъ божествъ въ Египтѣ
1913
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