Search results for "Mito"
showing 10 items of 2513 documents
Acyl-Chain Mismatch Driven Superlattice Arrangements in DPPC/DLPC/Cholesterol Bilayers
2010
Fluorescence and infrared spectroscopy and cholesterol oxidase activity were employed to investigate the effect of phosphatidylcholine (PC) acyl chain length mismatch on the lateral organizations of lipids in liquid-ordered dipalmitoyl-PC/dilauroyl-PC/cholesterol (DPPC/DLPC/CHOL) bilayers. Plots of steady-state fluorescence emission anisotropy of diphenylhexatriene (DPH) labeled PC (DPH-PC) embedded in the DPPC/DLPC/CHOL bilayers revealed significant peaks at several DPPC mole fractions (Y(DPPC)) when the cholesterol mole fraction (X(CHOL)) was fixed to particular values. Analogously, the DPH-PC anisotropy peaked at several critical X(CHOL)'s when Y(DPPC) was fixed. Acyl chain C-H and C hor…
An extension of the Burrows-Wheeler Transform and applications to sequence comparison and data compression
2005
We introduce a generalization of the Burrows-Wheeler Transform (BWT) that can be applied to a multiset of words. The extended transformation, denoted by E, is reversible, but, differently from BWT, it is also surjective. The E transformation allows to give a definition of distance between two sequences, that we apply here to the problem of the whole mitochondrial genome phylogeny. Moreover we give some consideration about compressing a set of words by using the E transformation as preprocessing.
La Antígona de Eurípides y el P. Oxy. 3317
2019
Eurípides trató el Ciclo Tebano en Fenicias y Suplicantes, obras que hemos conservado, y en Antígona, de la que sólo conservamos unos escasos fragmentos, al igual que de su Edipo; en estas dos últimas, por lo que podemos saber por los fragmentos y las referencias, se observa un distan- ciamiento en el tratamiento dramático de los mitos que observamos en Sófocles. Precisamente ésta es una de las pocas unanimidades que existen respecto a Antígona de Eurípides, que la joven heroína no compartía el destino de la sofoclea y, lejos de morir, se unía a Hemón y tenía con él un hijo. Determinar si esto era el punto final del drama o el arranque del mismo sigue siendo objeto de debate. El problema de…
Lungo il filo di Arianna. Voci del mito al femminile
2012
Le varianti del mito che hanno Arianna come protagonista sono molte e tutte cariche di significato. Il lavoro ha come protagoniste donne del mito, attraverso le voci di Gea, Pandora, Andromaca, Elena...La forma del monologo consente di "dare vita" al travaglio dell'animo femminile che, attraverso un processo di consapevolezza, rende reali situazioni vissute nella dimensione fantastica del mito. abstractita
On the Electrostatic Component of the Adhesional Interaction between Solid Substrates and Langmuir Monolayers
1991
The work of adhesion between Langmuir monolayers and solid surfaces in a hydrophilic Langmuir-Blodgett configuration has been measured as function of the surface charge densities σ of the contacting surfaces. It was derived from the equilibrium meniscus height which was measured with the transfer fluorescence microscope. The surface charge density of the contacting surfaces was varied by changing the subphase pH. With both surfaces negatively charged (dimyristoylphosphatidylethanolamine onto SiO2-substrates) and low charge densities (σ < 1 e−/100 A2)) we observe a decrease of the adhesion with increasing charge density. At high charge densities (dimyristoylphosphatidic acid onto SiO2-substr…
Chronic cocaine exposure impairs progenitor proliferation but spares survival and maturation of neural precursors in adult rat dentate gyrus
2006
Recent observations indicate that drugs of abuse, including alcohol and opiates, impair adult neurogenesis in the hippocampus. We have studied in rats the impact of cocaine treatment (20 mg/kg, daily, i.p.) on cell proliferation, survival and maturation following short-term (8-day) and long-term (24-day) exposure. Using 5'-bromo-2-deoxyuridine (BrdU) and Ki-67 as mitotic markers at the end of the drug treatments, we found that both short- and long-term cocaine exposures significantly reduced cell proliferation in the dentate gyrus (DG) of the hippocampus. By labelling mitotic cells with BrdU pulses before or during the early stages of the drug treatment, we determined that long-term cocaine…
Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and Downregulation of c-Myc.
2021
11 p.-9 fig.-4 tab.
In vitro and in vivo characterization of a new organic nitrate hybrid drug covalently bound to pioglitazone.
2014
<b><i>Background/Aims:</i></b> Organic nitrates represent a group of nitrovasodilators that are clinically used for the treatment of ischemic heart disease. The new compound CLC-3000 is an aminoethyl nitrate (AEN) derivative of pioglitazone, a thiazolidinedione antidiabetic agent combining the peroxisome proliferator-activated receptor &#947; agonist activity of pioglitazone with the NO-donating activity of the nitrate moiety. <b><i>Methods:</i></b> In vitro and in vivo characterization was performed by isometric tension recording, platelet function, bleeding time and detection of oxidative stress. <b><i>Results:</i></…
Cardiotoxicity mechanisms of the combination of BRAF-inhibitors and MEK-inhibitors.
2018
Many new drugs have appeared in last years in the oncological treatment scenario. Each drug carries an important set of adverse events, not less, cardiovascular adverse events. This aspect is even more important considering the increasing use of combination therapies with two drugs, or three drugs as in some ongoing clinical trials. Besides it represents a growing problem for Cardiologists, that face it in every day clinical practice and that will face it probably more and more in the coming years. This work reviews the mechanism of action of BRAF-inhibitors and MEK-inhibitors used together, the pathophysiological mechanisms that lead to cardiovascular toxicity. Particularly, it focuses on …
Protection of Azidothymidine-Induced Cardiopathology in Mice by Mildronate, a Mitochondria-Targeted Drug
2006
Azidothymidine, a nucleoside-analogue reverse transcriptase inhibitor (NRTI), is a commonly used antiretroviral drug in AIDS treatment, however its use is limited by severe toxic side effects due to its influence on mitochondria that result in myopathy, particularly affecting the cardiac muscle. We suggest that effective protection of azidothymidine- induced cardiopathology can be expected from drugs that are capable of targeting mitochondria. Therefore the present study in mice was carried out with mildronate, a cardioprotective drug of the aza-butyrobetaine class, which previously has been shown to act as a highly potent protector of mitochondrial processes. In our study, saline (control)…