Search results for "Mitral Valve Prolapse"
showing 6 items of 16 documents
A giant left atrium in a patient with Barlow syndrome, abnormal chordae tendineae, and perforation of the anterior mitral leaflet
2019
Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia
2019
Mitral valve diseases affect approximately 3% of the population and are the most common reasons for valvular surgery because no drug-based treatments exist. Inheritable genetic mutations have now been established as the cause of mitral valve insufficiency, and four different missense mutations in the filamin A gene (FLNA) have been found in patients suffering from non-syndromic mitral valve dysplasia (MVD). The FLNA protein is expressed, in particular, in endocardial endothelia during fetal valve morphogenesis and is key in cardiac development. The FLNA-MVD causing mutations are clustered in the N-terminal region of FLNA. How the mutations in FLNA modify its structure and function, have mos…
Transapical beating-heart chordae implantation in mitral regurgitation: a new horizon for repairing mitral valve prolapse
2016
Mitral regurgitation (MR) is increasingly prevalent in western countries despite reduced incidence of rheumatic disease (1,2). MR results from several heterogeneous conditions, including disorders of the valve leaflets, mitral annulus, chordae tendineae, papillary muscles and left ventricle (LV). MR causes are roughly classified as primary (i.e. organic/structural) or secondary (i.e. functional/non-structural) (3).
Diagnostic value of transesophageal echocardiography in patients with coronary artery disease and mitral insufficiency
1991
Any diagnosis of mitral regurgitation must always include the etiology. The clinical history is only rarely informative, as are chest x-ray examinations. The ECG is of value to diagnose coronary artery disease with or without previous myocardial infarction — but further differentiation is not possible. During heart catheterization mitral insufficiency can be diagnosed and quantified according to Seller’s classification [1]. A differentiation of etiology is only rarely possible. Rheumatic heart disease and mitral valve prolapse can be differentiated.
Heart involvement in rheumatoid arthritis: systematic review and meta-analysis.
2013
Abstract Objective The aim of our study was to conduct a systematic review with meta-analysis of the current case–control studies about the valvular and pericardial involvement in patients with Rheumatoid Arthritis (RA), asymptomatic for cardiovascular diseases. Methods Case–control studies were identified by searching PubMed (1975–2010) and the Cochrane Central Register of Controlled Trials (CENTRAL) (1975–2010). Participants were adult patients with RA asymptomatic for cardiovascular diseases, and the outcome measure was the presence of cardiac involvement. Results Quantitative synthesis included 10 relevant studies out of 2326 bibliographic citations that had been found. RA resulted sign…