Search results for "Modell"

Isolation and Characterization of CD276+/HLA-E+ Human Subendocardial Mesenchymal Stem Cells from Chronic Heart Failure Patients: Analysis of Differen…

2012

Mesenchymal stem cells (MSCs) are virtually present in all postnatal organs as well as in perinatal tissues. MSCs can be differentiated toward several mature cytotypes and interestingly hold potentially relevant immunomodulatory features. Myocardial infarction results in severe tissue damage, cardiomyocyte loss, and eventually heart failure. Cellular cardiomyoplasty represents a promising approach for myocardial repair. Clinical trials using MSCs are underway for a number of heart diseases, even if their outcomes are hampered by low long-term improvements and the possible presence of complications related to cellular therapy administration. Therefore, elucidating the presence and role of MS…

APPRENDERE AL MUSEO STUDIO DI CASO - LA VALIDITA’ DI UN MODELLO DI APPROCCIO DI TIPO ESPLORATIVO-ESPERENZIALE AL BENE MUSEALE COME OGGETTO DALLE MOLT…

Il museo, luogo privilegiato per l'educazione al Patrimonio culturale, per la sua funzione educativa, può collaborare produttivamente con l'istituzione scolastica, in vista di un apprendimento efficace basato sulla valorizzazione dei suoi oggetti e collezioni. Lo studio di caso oggetto del presente lavoro, intende mostrare con approccio qualitativo, la validità di un modello teorico-applicativo per la formazione dei docenti, basato sull'esplorazione della concezione di museo, sulla considerazione del valore antropologico del conservare, sulle potenzialità apprenditive delle "cose" che possono fornire innumerevoli spunti per una programmazione multidisciplinare ed interdisciplinare.

Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: a modelling…

2017

Background Hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality worldwide. In the European Union (EU), treatment and cure of HCV with direct-acting antiviral therapies began in 2014. WHO targets are to achieve a 65% reduction in liver-related deaths, a 90% reduction of new viral hepatitis infections, and 90% of patients with viral hepatitis infections being diagnosed by 2030. This study assessed the prevalence of HCV in the EU and the level of intervention required to achieve WHO targets for HCV elimination. Methods We populated country Markov models for the 28 EU countries through a literature search of PubMed and Embase between Jan 1, 2000, and March 31, 201…

Graphical models for estimating dynamic networks

2012

Het bepalen van dynamische netwerken met behulp van data is een actief onderzoeksgebied, met name in de systeem biologie. Het schatten van de structuur van een netwerk heeft te maken met het bepalen van de aan of afwezigheid van een relatie tussen de hoekpunten in de graaf. Grafische modellen definiëren deze relaties via conditionele afhankelijkheid. In Gaussiaanse grafische modellen (GGM) wordt verondersteld dat de hoekpunten een normale verdeling volgen. Dit heeft grote voordelen vanwege de computationele handelbaarheid van GGM. Standaard GGM zijn echter niet bruikbaar om grote netwerken te bestuderen, i.e. als het aantal waarnemingen minder is dan het aantal hoekpunten van de graaf. Rece…

PMT: New analytical framework for automated evaluation of geo-environmental modelling approaches

2019

Geospatial computation, data transformation to a relevant statistical software, and step-wise quantitative performance assessment can be cumbersome, especially when considering that the entire modelling procedure is repeatedly interrupted by several input/output steps, and the self-consistency and self-adaptive response to the modelled data and the features therein are lost while handling the data from different kinds of working environments. To date, an automated and a comprehensive validation system, which includes both the cutoff-dependent and –independent evaluation criteria for spatial modelling approaches, has not yet been developed for GIS based methodologies. This study, for the fir…

Determinants of performance drivers in online food delivery platforms: a dynamic performance management perspective

2022

PurposeThis study aims to demonstrate that the Dynamic Performance Management (DPM) framework, integrating performance management with system dynamics modelling, enables decision-makers to identify sustainable strategies in online food delivery platforms, thereby avoiding company failure.Design/methodology/approachThis study undertakes a multistep methodological approach. After the literature review, a retrospective case study approach was used. To build the DPM framework and the system dynamics simulation model, primary and secondary data were collected and analysed.FindingsThis study by adopting the DPM perspective highlights the critical role performance drivers play to assess the viabil…

Supporting the natural gas supply chain public policies through simulation methods: A dynamic performance management approach

2018

Natural gas is considered the transitional fuel par excellence between fossil and renewable sources, considering its low cost, greater efficiency and lesser impact on the environment. This is the reason why its demand levels have increased worldwide, requiring intervention of public and private stakeholders in order to meet these increments. The participation of diverse interconnected stakeholders (key actors) of the supplier-client form, constitutes a supply chain for natural gas, in which the effects of the application of public policy actions can be analysed in the time, using Dynamic Performance Management DPM methodology. The results of the model show the behaviour of the reserves, pro…

Modelling anaerobic biomass growth kinetics with a substrate threshold concentration.

2004

Abstract Many bacteria have been observed to stop growing below a certain substrate threshold concentration. In this study, a modification of the Monod kinetics expression has been proposed to take into account this substrate threshold concentration observed in bacterial growth. Besides the threshold concentration no additional parameters have been added to the kinetic expression and so, only the substrate threshold concentration and the half-saturation constant have to be estimated for model calibration purposes. Furthermore, for parameter estimation purposes, practical identifiability of this new function has been studied and the results have been satisfactory. The new model has been appl…

Experimental models of orthodontic tooth movement and their effects on periodontal tissues remodelling.

2021

Made available in DSpace on 2022-04-29T08:31:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objectives: The present study aimed to compare two different models of orthodontic tooth movement (OTM) in rats by evaluating tooth movement efficiency and periodontal tissues remodelling. Design: Fifteen animals were randomly distributed into 3 groups: control group (untreated); ligature appliance (LA) as experimental OTM using a closed coil spring fixed around maxillary first molar by steel ligature; occlusal appliance (OA) as experimental OTM using a closed coil spring attached on the occlusal surface of the maxillary f…

Breather dynamics in a stochastic sine-Gordon equation: evidence of noise-enhanced stability

2023

The dynamics of sine-Gordon breathers is studied in the presence of dissipative and stochastic perturbations. Taking a stationary breather with a random phase value as the initial state, the performed simulations demonstrate that a spatially-homogeneous noisy source can make the oscillatory excitation more stable, i.e., it enables the latter to last significantly longer than it would in a noise-free scenario. Both the frequency domain and the localization of energy are examined to document the effectiveness of the noise-enhanced stability phenomenon, which emerges as a nonmonotonic behavior of an average characteristic time for the breather as a function of the noise intensity. The influenc…