Search results for "Models"

Influence of environmental factors on the spatial distribution and diversity of forest soil in Latvia

2012

This study was carried out to determine the spatial relationships between environmental factors (Quaternary deposits, topographical situation, land cover, forest site types, tree species, soil texture) and soil groups, and their prefix qualifiers (according to the international Food and Agricultural Organization soil classification system World Reference Base for Soil Resources [FAO WRB]). The results show that it is possible to establish relationships between the distribution of environmental factors and soil groups by applying the generalized linear models in data statistical analysis, using the R 2.11.1 software for processing data from 113 sampling plots throughout the forest terri…

Influence of structure on the tissue dynamics of the human soleus muscle observed in MRI studies during isometric contractions.

2006

This article investigates how the internal structure of muscle and its relationship with tendon and even skeletal structures influence the translation of muscle fiber contractions into movement of a limb. Reconstructions of the anatomy of the human soleus muscle from the Visible Human Dataset (available from the National Library of Medicine), magnetic resonance images (MRI), and cadaver studies revealed a complex 3D connective tissue structure populated with pennate muscle fibers. The posterior aponeurosis and the median septum of the soleus form the insertion of the muscle and are continuous with the Achilles tendon. The distal extremities of the pennate muscle fibers attach to these struc…

Joined effects of pennation angle and tendon compliance on fibre length in isometric contractions: a simulation study.

1998

The main purpose of this study was to investigate the joined behaviours of tendon and pennation angle during maximal isometric contractions. A musculotendon model of the human soleus muscle was simulated as a function of ankle joint position, which determines the soleus length. Analysis of the respective values of tendon length and pennation angle for various musculotendon lengths showed that the primary effects of tendon elasticity and pennation angle variation were to reduce the fibre length variations by absorption of the musculotendon lengthening. The efficiency of this reduction process was the highest at short soleus lengths and principally related to tendon length variations. Finally…

Solidarity Purchase Groups and the new critical and ethical consumer trends: first results of a direct study in Sicily

2011

Recently in Italy, the evolution of food consumption occurs through the purchase of healthy and environmentally friendly foods. This trend is confirmed by the birth, in Italy of many solidarity purchase groups (called in Italy Gruppi di Acquisto Solidale or GAS),made up of individuals or families who choose to purchase products with a high ethical value. In this paper we try to identify socio-economic conditions and motivation of individual members of GAS, and for this purpose we developed over 205 questionnaires.

MR2979407 Bougie, Jonathan; Gangopadhyaya, Asim; Mallow, Jeffry; Rasinariu, Constantin Supersymmetric quantum mechanics and solvable models. Symmetry…

2013

Sorafenib in advanced hepatocellular carcinoma

2008

none 25 BACKGROUND: No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma. METHODS: In this multicenter, phase 3, double-blind, placebo-controlled trial, we randomly assigned 602 patients with advanced hepatocellular carcinoma who had not received previous systemic treatment to receive either sorafenib (at a dose of 400 mg twice daily) or placebo. Primary outcomes were overall survival and the time to symptomatic progression. Seconda…

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon.

2012

Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most frequently occurring tumors worldwide and is also considered to be the most lethal of the cancer systems, accounting for approximately one third of all malignancies. Although the clinical diagnosis and management of early-stage HCC has improved significantly, HCC prognosis is still extremely poor. Furthermore, advanced HCC is a highly aggressive tumor with a poor or no response to common therapies. Therefore, new effective and well-tolerated therapy strategies are urgently needed. Targeted therapies have entered the field of anti-neopl…

Conquests and perspectives of cardio-oncology in the field of tumor angiogenesis-targeting tyrosine kinase inhibitor-based therapy

2015

Abstract: Introduction: Angiogenesis is fundamental for tumor development and progression. Hence, anti-angiogenic drugs have been developed to target VEGF and its receptors (VEGFRs). Several tyrosine kinase inhibitors (TKIs) have been developed over the years and others are still under investigation, each anti-VEGFR TKI showing a different cardiotoxic profile. Knowledge of the cardiac side-effects of each drug and the magnitude of their expression and frequency can lead to a specific approach. Areas covered: This work reviews the mechanism of action of anti-VEGFR TKIs and the pathophysiological mechanisms leading to cardiotoxicity, followed by close examination of the most important drugs i…

Development of the BCI Device Controlling C++ Software, Based on Existing Open Source Projects

2021

The possibility of using the BCI open source code for building BCI controlled device, based on small AVR or ARM microcontrollers was considered. Some techniques to extract code snippets from other BCI projects were presented in the case of OpenViBE as the code donor. Problem with obtaining driver source codes for factory BCI devices has been pointed out.

Southern-Tyrrhenian seismicity in space-time-magnitude domain

2006

An analysis is conducted on a catalogue containing more than 2000 seismic events
 occurred in the southern Tyrrhenian Sea between 1988 and October 2002, as an attempt
 to characterise the main seismogenetic processes active in the area in space, time and magnitude domain by means of the parameters of phenomenological laws.
 
 We chose to adopt simple phenomenological models, since the low number of data did
 not allow to use more complex laws.
 
 The two main seismogenetic volumes present in the area were considered for the purpose
 of this work. The first includes a nearly homogeneous distribution of hypocentres in a
 NW steeply dipping layer as far as a…