Search results for "Modula"
showing 10 items of 1481 documents
Chemotherapy and immunomodulation: from immunogenic chemotherapies to novel therapeutic strategies.
2013
Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials
2021
Medicinal mushrooms have important health benefits and exhibit a broad spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, antihyperlipidemic, antidiabetic, digestive, hepatoprotective, neuroprotective, nephroprotective, osteoprotective, and hypotensive activities. The growing interest in mycotherapy requires a strong commitment from the scientific community to expand clinical trials and to propose supplements of safe origin and genetic purity. Bioactive compounds of selected medicinal mushrooms and their effects and mechanisms in in vitro and in vivo clinical stu…
Comparison of two different devices to assess intraocular lenses
2016
[EN] In this paper, we have compared the performance of two commercial systems, Kaleo-I and IOLA Plus, in the characterization of monofocal intraocular lenses (IOLs) according to the International Standard requirements (ISO 11979-2). The dioptric power (DP) and the Modulation Transfer Function (MTF) at 100.1p/mm and 3.0 mm aperture have been measured with both instruments in twenty commercial monofocal HEMA IOLs and their agreement was assessed by Bland Altman analysis. Compared with the designed power, IOLA Plus gave lower values in 85% of measures: Kaleo I errors are dependent on the power of the lens: measurements were higher than the designed power in the low-medium power range and lowe…
Identification of multiplicatively acting modulatory mutational signatures in cancer
2022
Abstract Background A deep understanding of carcinogenesis at the DNA level underpins many advances in cancer prevention and treatment. Mutational signatures provide a breakthrough conceptualisation, as well as an analysis framework, that can be used to build such understanding. They capture somatic mutation patterns and at best identify their causes. Most studies in this context have focused on an inherently additive analysis, e.g. by non-negative matrix factorization, where the mutations within a cancer sample are explained by a linear combination of independent mutational signatures. However, other recent studies show that the mutational signatures exhibit non-additive interactions. Resu…
Error-Based Interference Detection in WiFi Networks
2017
In this paper we show that inter-technology interference can be recognized by commodity WiFi devices by monitoring the statistics of receiver errors. Indeed, while for WiFi standard frames the error probability varies during the frame reception in different frame fields (PHY, MAC headers, payloads) protected with heterogeneous coding, errors may appear randomly at any point during the time the demodulator is trying to receive an exogenous interfering signal. We thus detect and identify cross-technology interference on off-the-shelf WiFi cards by monitoring the sequence of receiver errors (bad PLCP, bad PCS, invalid headers, etc.) and develop an Artificial Neural Network (ANN) to recognize t…
Halo-independent methods for inelastic dark matter scattering
2013
We present halo-independent methods to analyze the results of dark matter direct detection experiments assuming inelastic scattering. We focus on the annual modulation signal reported by DAMA/LIBRA and present three different halo-independent tests. First, we compare it to the upper limit on the unmodulated rate from XENON100 using (a) the trivial requirement that the amplitude of the annual modulation has to be smaller than the bound on the unmodulated rate, and (b) a bound on the annual modulation amplitude based on an expansion in the Earth's velocity. The third test uses the special predictions of the signal shape for inelastic scattering and allows for an internal consistency check of …
Large-scale Cosmic-Ray Anisotropies above 4 EeV Measured by the Pierre Auger Observatory
2018
We present a detailed study of the large-scale anisotropies of cosmic rays with energies above 4 EeV measured using the Pierre Auger Observatory. For the energy bins [4,8] EeV and $E\geq 8$ EeV, the most significant signal is a dipolar modulation in right ascension at energies above 8 EeV, as previously reported. In this paper we further scrutinize the highest-energy bin by splitting it into three energy ranges. We find that the amplitude of the dipole increases with energy above 4 EeV. The growth can be fitted with a power law with index $\beta=0.79\pm 0.19$. The directions of the dipoles are consistent with an extragalactic origin of these anisotropies at all the energies considered. Addi…
Implementation of the Community Earth System Model (CESM) version 1.2.1 as a new base model into version 2.50 of the MESSy framework
2016
Abstract. The Community Earth System Model (CESM1), maintained by the United States National Centre for Atmospheric Research (NCAR) is connected with the Modular Earth Submodel System (MESSy). For the MESSy user community, this offers many new possibilities. The option to use the Community Atmosphere Model (CAM) atmospheric dynamical cores, especially the state-of-the-art spectral element (SE) core, as an alternative to the ECHAM5 spectral transform dynamical core will provide scientific and computational advances for atmospheric chemistry and climate modelling with MESSy. The well-established finite volume core from CESM1(CAM) is also made available. This offers the possibility to compare …
Cannabinoid CB1 receptor activation modulates spontaneous contractile activity in mouse ileal longitudinal muscle.
2007
The purpose of the present study was to examine whether cannabinoid receptor agonists influence spontaneous contractile activity of longitudinal muscle in mouse ileum in vitro. Isolated segments of mouse ileum displayed spontaneous contractions with an amplitude and frequency of about 300 mg and 30 cpm, respectively. The endocannabinoid anandamide (1-100 microM), the selective cannabinoid CB(1) receptor agonist, ACEA (0.1 microM-10 microM), but not the selective cannabinoid CB(2) receptor agonist, JWH 133 (0.1 microM-10 microM), reduced in a concentration-dependent manner the spontaneous mechanical activity. The inhibitory effect consisted in a decrease of the mean amplitude of longitudinal…
Steered Response Power Localization of Acoustic Passband Signals
2017
The vast majority of localization approaches using phase transform (PHAT) consider that the sources of interest are wideband low-pass sources. While this may be the usual case for common audio signals such as speech, PHAT methods are affected negatively by modulation artifacts when the sources to be localized are passband signals. In these cases, steered response power PHAT localization becomes less robust. This letter analyzes the form of generalized cross-correlation functions with PHAT when passband acoustic signals are considered, proposing approaches for increasing the localization performance through the mitigation of these negative effects.