Search results for "Modula"
showing 10 items of 1481 documents
Influence of spatial delay on the modulational instability in a composite system with a controllable nonlinearity.
2017
A theoretical investigation of the modulational instability (MI) in a composite system with a nonlocal response function is presented. A composite system of silver nanoparticles in acetone is chosen, whose nonlinearity can be delicately varied by controlling the volume fraction of the constituents, thus enabling the possibility of nonlinearity management. A pump-probe counterpropagation configuration has been assumed, and the interplay between the competing nonlinearities and the nonlocalities in the MI dynamics is systematically explored. A different class of nonlocalities have been considered, and the study reveals that the nonlocality critically depends on the kind of nonlocal function. …
Zero Ripple Current with Coupled Inductors in Continuous Conduction Mode under PWM Signals
2020
This article presents a generalized analysis to explain current ripple of an $m$ windings coupled inductor with a given coupling factor $k_{ij}$ for each pair of windings and then studies more in detail its use in the continuous conduction mode and with pulsewidth modulated signals. To determine the current ripple, a generalized expression of the equivalent inductance of each winding is calculated, including the influence of voltage unbalance. In the ideal case, the equivalent inductance shows that the current ripple can only become $m$ times smaller than that with uncoupled inductors. But in the unbalanced case, some divergences of the equivalent inductance appear that are responsible for …
Robust model-following control of parallel UPS single-phase inverters
2008
This paper presents a robust control technique applied to modular uninterruptible power-supply (UPS) inverters operating in parallel. When compared to conventional proportional-integral (PI) control, the proposed technique improves the response of the output voltage to load steps and to high distorted output currents, reducing the distortion of the output voltage. Furthermore, an excellent distribution of currents between modules is achieved, resulting in fine power equalization between the inverters on stream. The crossover frequency of the different loop gains involved is moderate, so that robustness to variations of the operation point and to modeling uncertainties is achieved. A compara…
Timing techniques applied to distributed modular high-energy astronomy: the H.E.R.M.E.S. project
2021
The HERMES-TP/SP (High Energy Rapid Modular Ensemble of Satellites -- Technologic and Scientific Pathfinder) is an in-orbit demonstration of the so-called distributed astronomy concept. Conceived as a mini-constellation of six 3U nano-satellites hosting a new miniaturized detector, HERMES-TP/SP aims at the detection and accurate localisation of bright high-energy transients such as Gamma-Ray Bursts. The large energy band, the excellent temporal resolution and the wide field of view that characterize the detectors of the constellation represent the key features for the next generation high-energy all-sky monitor with good localisation capabilities that will play a pivotal role in the future …
The HERMES-Technologic and Scientific Pathfinder
2020
HERMES-TP/SP (High Energy Rapid Modular Ensemble of Satellites Technologic and Scientific Pathfinder) is a constellation of six 3U nano-satellites hosting simple but innovative X-ray detectors, characterized by a large energy band and excellent temporal resolution, and thus optimized for the monitoring of Cosmic High Energy transients such as Gamma Ray Bursts and the electromagnetic counterparts of Gravitational Wave Events, and for the determination of their positions. The projects are funded by the Italian Ministry of University and Research and by the Italian Space Agency, and by the European Union Horizon 2020 Research and Innovation Program under Grant Agreement No. 821896. HERMES-TP/S…
Furocoumarins as multi-target agents in the treatment of cystic fibrosis.
2019
Multi-target molecular entities, offer a path to progress both in understanding causes of disease and in defining effective small molecule treatments. Coumarin and its derivatives belong to an important group of natural compounds with diverse biological properties. They are found in vegetables and plants for which literature reports thousands of publications for the great variety of biological applications among which the photoprotective effects, thus being considered multi-targeting agents. Their furan condensed analogues constitute the family of furocoumarins, less represented in the literature, endowed with photosensitizing properties and often used for the treatment of skin diseases suc…
Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion.
2013
Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins. Here we show that HCMV immunoevasins differentially impair T cell recognition of epitopes from the same viral antigen, immediate-early 1 (IE-1), that are presented by different MHC class I allotypes. In the presence of immunoevasins, HLA-A- and HLA-B-restricted T cell clones were ineffective, but HLA-C*0702-restricted T cell clones recognized and killed infected cells. Resistance of HLA-C*0702 to viral immunoevasins US2 and US11 was mediated by the alpha3 domain and C-terminal region …
Daratumumab for the Treatment of Multiple Myeloma
2018
This mini-review will summarize the present state of development of the CD38 antibody daratumumab for the treatment of multiple myeloma.
Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion.
2013
Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase. It is generally assumed that this arginine deficiency induces a global shut-down of T cell activation with ensuing tumor immune escape. While the impact of arginine depletion on polyclonal T cell proliferation and cytokine secretion is well documented, its influence on chemotaxis, cytotoxicity and antigen specific activation of human T cells has not been demonstrated so far. We show here that chemotaxis and early calcium signaling of human T cells are unimpaired in the absence of arginine. We then analyzed CD8(+) T cell activation…
Electron-interacting dark matter: Implications from DAMA/LIBRA-phase2 and prospects for liquid xenon detectors and NaI detectors
2019
We investigate the possibility for the direct detection of low-mass (GeV scale) weakly interacting massive particles (WIMP) dark matter in scintillation experiments. Such WIMPs are typically too light to leave appreciable nuclear recoils but may be detected via their scattering off atomic electrons. In particular, the DAMA Collaboration [R. Bernabei et al., Nucl. Phys. At. Energy 19, 307 (2018)] has recently presented strong evidence of an annual modulation in the scintillation rate observed at energies as low as 1 keV. Despite a strong enhancement in the calculated event rate at low energies, we find that an interpretation in terms of electron-interacting WIMPs cannot be consistent with ex…