Search results for "Modularity"
showing 10 items of 64 documents
Identifying modularity structure of a genetic network in gene expression profile data
2009
Aim of this paper is to define a new statistical framework to identify central modules in Gaussian Graphical Models (GGMs) estimated by gene expression data measured on a sample of patients with negative molecular response to Imatinib. Imanitib is a drug used to treat certain types of cancer that in many statistical studies has been reported to have a significant clinical effect on chronic myeloid leukemia (CML) in chronic phase as well as in blast crisis. For central module in a GGM we intend a module containing genes that are defined differently expressed.
Splitting the dynamics of large biochemical interaction networks
2003
This article is inscribed in the general motivation of understanding the dynamics on biochemical networks including metabolic and genetic interactions. Our approach is continuous modeling by differential equations. We address the problem of the huge size of those systems. We present a mathematical tool for reducing the size of the model, master-slave synchronization, and fit it to the biochemical context.
Immune networks: Multi-tasking capabilities at medium load
2013
Associative network models featuring multi-tasking properties have been introduced recently and studied in the low load regime, where the number $P$ of simultaneously retrievable patterns scales with the number $N$ of nodes as $P\sim \log N$. In addition to their relevance in artificial intelligence, these models are increasingly important in immunology, where stored patterns represent strategies to fight pathogens and nodes represent lymphocyte clones. They allow us to understand the crucial ability of the immune system to respond simultaneously to multiple distinct antigen invasions. Here we develop further the statistical mechanical analysis of such systems, by studying the medium load r…
Using Cloud, Modularity, and Make-to-Upgrade Strategy for Integrating Customized-Oriented Supply Networks
2013
In the current global business individual demand play crucial roles. Customized-oriented supply networks are being proliferated in manufacturing industries, yet integration of their members is still quite challenging. As a practical solution, in this paper a new collaborative approach out of modularity structure, cloud computing, and a novel production strategy, called Make-to-Upgrade (MTU), is suggested. The complementary aspects of these techniques are highlighted and briefly explained here. MTU is as a strategy for future products with new characteristics, e.g., upgradability.
Opposing Forces of Social Attraction and Social Avoidance Drive Network Modularity
2020
SUMMARY: How interactions between individuals contribute to the emergence of complex societies is a major question in biology. Nonetheless, little remains known about how simple rules of social attraction (e.g. to information) and social avoidance (e.g. of disease) interact to shape sociality. We developed an individual-based model where individuals choose with whom to interact depending on the status of group mates (informed and/or infected). Statistical models indicate that the emergence of social structure depends on the cost/benefit trade-offs underlying the system. Critically, pressures that optimize social relationships – i.e. minimize risky connections while favouring those that maxi…
What Is Synthetic Biology?
2014
Synthetic biology aims at the design and construction of biological devices and systems for useful purposes. From an ideal engineering perspective synthetic biology works from rational design made through a few conceptual pillars, namely abstraction, standardization and modularity. Nevertheless, the combination of our still fragmentary biological knowledge and the messy nature of biological devices are major challenges for engineering life in a predictive manner. It is urgent to build bridges between different disciplines, from biology to engineer and back, to pursue this extraordinary goal of making life.
A Neural Multi-Agent Architecture for an Autonomous Mobile Robot Control
1999
The aim of this paper is to introduce a multi-agent architecture for an autonomous robot control oriented to obtain high design modularity and high parallelism of decision processes. A multi-agent approach allows us to design several specialized agents and each of them is optimized in order to solve a single part of the whole task. Each agent is able to cooperate with other agent exchanging information, so the robot is able to make the appropriate policy of management to reach a prefixed goal. We tested the proposed architecture with a simple application: an autonomous mobile robot performs object retrieval tasks into unknown structured environments. The robot is not given a priori map of t…
Integrazione di celle fotovoltaiche ibride nel vetromattone
2012
L’invenzione riguarda l’integrazione del vetromattone con celle solari ibride (organiche/inorganiche), conosciute come Dye-sensitized Solar Cell (DSC). La combinazione del vetromattone con le DSC consente di migliorare le prestazioni del prodotto originario rendendolo in grado di produrre energia pulita. Le caratteristiche di trasparenza e isolamento termo-acustico del prodotto possono essere regolate agendo sulla configurazione delle DSC. Il prodotto può essere assemblato a formare pannelli fotovoltaici per la realizzazione di facciate traslucide energeticamente “attive” in varie condizioni luminose (condizioni di luce diffusa o artificiale) e indipendentemente dall’angolo di radiazione so…
An Image Segmentation Algorithm based on Community Detection
2016
International audience; With the recent advances in complex networks, image segmentation becomes one of the most appropriate application areas. In this context, we propose in this paper a new perspective of image segmentation by applying two efficient community detection algorithms. By considering regions as communities, these methods can give an over-segmented image that has many small regions. So, the proposed algorithms are improved to automatically merge those neighboring regions agglomerative to achieve the highest modularity/stability. To produce sizable regions and detect homogeneous communities, we use the combination of a feature based on the Histogram of Oriented Gradients of the …
Vertical Integration due to Software Systems' Modularity
2009
In their product portfolio, OSS/BSS software vendors make products pre-integrated with each other as well as with other related OSS/BSS products. Prior to the full-scale development and integration, it is vital for these vendors to assess which products are reasonable to integrate. Such integration of software may be aimed at achieving different goals, such as: Reducing software integration efforts. Software vendors aim at maximizing their profits, whereas their customers (i.e., CSPs) aim at minimizing their costs by avoiding the integration job. As a result, to approach a win–win scenario, vendors provide already integrated products or subsystems (pre-integrated modules). Sharing similar k…