Search results for "Modulation"
showing 10 items of 948 documents
Influence of spatial delay on the modulational instability in a composite system with a controllable nonlinearity.
2017
A theoretical investigation of the modulational instability (MI) in a composite system with a nonlocal response function is presented. A composite system of silver nanoparticles in acetone is chosen, whose nonlinearity can be delicately varied by controlling the volume fraction of the constituents, thus enabling the possibility of nonlinearity management. A pump-probe counterpropagation configuration has been assumed, and the interplay between the competing nonlinearities and the nonlocalities in the MI dynamics is systematically explored. A different class of nonlocalities have been considered, and the study reveals that the nonlocality critically depends on the kind of nonlocal function. …
Zero Ripple Current with Coupled Inductors in Continuous Conduction Mode under PWM Signals
2020
This article presents a generalized analysis to explain current ripple of an $m$ windings coupled inductor with a given coupling factor $k_{ij}$ for each pair of windings and then studies more in detail its use in the continuous conduction mode and with pulsewidth modulated signals. To determine the current ripple, a generalized expression of the equivalent inductance of each winding is calculated, including the influence of voltage unbalance. In the ideal case, the equivalent inductance shows that the current ripple can only become $m$ times smaller than that with uncoupled inductors. But in the unbalanced case, some divergences of the equivalent inductance appear that are responsible for …
Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion.
2013
Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins. Here we show that HCMV immunoevasins differentially impair T cell recognition of epitopes from the same viral antigen, immediate-early 1 (IE-1), that are presented by different MHC class I allotypes. In the presence of immunoevasins, HLA-A- and HLA-B-restricted T cell clones were ineffective, but HLA-C*0702-restricted T cell clones recognized and killed infected cells. Resistance of HLA-C*0702 to viral immunoevasins US2 and US11 was mediated by the alpha3 domain and C-terminal region …
Daratumumab for the Treatment of Multiple Myeloma
2018
This mini-review will summarize the present state of development of the CD38 antibody daratumumab for the treatment of multiple myeloma.
Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion.
2013
Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase. It is generally assumed that this arginine deficiency induces a global shut-down of T cell activation with ensuing tumor immune escape. While the impact of arginine depletion on polyclonal T cell proliferation and cytokine secretion is well documented, its influence on chemotaxis, cytotoxicity and antigen specific activation of human T cells has not been demonstrated so far. We show here that chemotaxis and early calcium signaling of human T cells are unimpaired in the absence of arginine. We then analyzed CD8(+) T cell activation…
Electron-interacting dark matter: Implications from DAMA/LIBRA-phase2 and prospects for liquid xenon detectors and NaI detectors
2019
We investigate the possibility for the direct detection of low-mass (GeV scale) weakly interacting massive particles (WIMP) dark matter in scintillation experiments. Such WIMPs are typically too light to leave appreciable nuclear recoils but may be detected via their scattering off atomic electrons. In particular, the DAMA Collaboration [R. Bernabei et al., Nucl. Phys. At. Energy 19, 307 (2018)] has recently presented strong evidence of an annual modulation in the scintillation rate observed at energies as low as 1 keV. Despite a strong enhancement in the calculated event rate at low energies, we find that an interpretation in terms of electron-interacting WIMPs cannot be consistent with ex…
Search for Event Rate Modulation in XENON100 Electronic Recoil Data
2015
We have searched for periodic variations of the electronic recoil event rate in the (2-6) keV energy range recorded between February 2011 and March 2012 with the XENON100 detector, adding up to 224.6 live days in total. Following a detailed study to establish the stability of the detector and its background contributions during this run, we performed an un-binned profile likelihood analysis to identify any periodicity up to 500 days. We find a global significance of less than 1 sigma for all periods suggesting no statistically significant modulation in the data. While the local significance for an annual modulation is 2.8 sigma, the analysis of a multiple-scatter control sample and the phas…
Observations of Forbush Decreases of cosmic ray electrons and positrons with the Dark Matter Particle Explorer
2021
The Forbush Decrease (FD) represents the rapid decrease of the intensities of charged particles accompanied with the coronal mass ejections (CMEs) or high-speed streams from coronal holes. It has been mainly explored with ground-based neutron monitors network which indirectly measure the integrated intensities of all species of cosmic rays by counting secondary neutrons produced from interaction between atmosphere atoms and cosmic rays. The space-based experiments can resolve the species of particles but the energy ranges are limited by the relative small acceptances except for the most abundant particles like protons and helium. Therefore, the FD of cosmic ray electrons and positrons have …
Modulational instability and generation of self-induced transparency solitons in resonant optical fibers
2009
International audience; We consider continuous-wave propagation through a fiber doped with two-level resonant atoms, which is described by a system of nonlinear Schrodinger-Maxwell-Bloch (NLS-MB) equations. We identify the modulational instability (MI) conditions required for the generation of ultrashort pulses, in cases of both anomalous and normal GVD (group-velocity dispersion). It is shown that the self-induced transparency (SIT) induces non-conventional MI sidebands. The main result is a prediction of the existence of both bright and dark SIT solitons in the anomalous and normal GVD regimes.
First demonstration of active plasmonic device in true data traffic conditions: On/off thermo-optic modulation using a hybrid silicon-plasmonic asymm…
2012
We demonstrate the first system-level evaluation of an active plasmonic device in 10Gb/s data traffic conditions. Thermo-optic ON/OFF modulation with 3μs response time and 10mW power consumption is presented using an asymmetric MZI silicon-plasmonic gate.