Search results for "Molecules"

Is Myeloperoxidase a Key Component in the ROS-Induced Vascular Damage Related to Nephropathy in Type 2 Diabetes?

2013

AbstractIt is still unclear whether microvascular complications of type 2 diabetes correlate with leukocyte-endothelium interactions and/or myeloperoxidase (MPO) levels. In the present study, we found that serum levels of glucose, the rate of ROS and MPO concentration were higher in type 2 diabetic patients. Patients with nephropathy (39.6%) presented higher MPO levels that correlate positively with the albumin/creatinine ratio (r=0.59, p<0.05). In addition, nephropatic patients showed increased leukocyte-endothelium interactions due to an undermining of polymorphonuclear leukocytes (PMN) rolling velocity and increased rolling flux and adhesion, which was accompanied by a rise in levels of …

Investigational agents for Crohn's disease.

2010

IMPORTANCE OF THE FIELD: Increased understanding of the biological mechanisms of Crohn's disease has opened the door to a large number of new molecules; some of these are approved for clinical use, while others remain under evaluation. In this review, we examine the clinical efficacy of all the new drugs that have been evaluated in controlled trials in the last 12 years. AREAS COVERED IN THIS REVIEW: Anti-TNF therapy has been reviewed briefly, given the many comprehensive reviews on this topic; attention is focused mainly on the other biological therapies. In assessing the clinical efficacy of these molecules, we consider only the remission rate, as this is considered the most meaningful en…

Microalbuminuria and endothelial activation in treated and untreated diabetic and non-diabetic hypertensives

2004

Molekulārās sensibilizācijas profila pret suņiem saistība ar astmas un alerģiska rinīta kontroles rādītājiem

2022

Izpētes objekts Šis pētījums tika veikts, lai novērtētu suņa alergēnu molekulu sensitizāciju saistību ar astmu un alerģisko rinītu. Pētījuma metodoloģija Tika analizēti dati pacientiem, kuriem veikta ALEX vai ALEX2 paneļa testēšana un iegūts sensitizāciju profils katrai suņa alergēna molekulai (Can f 1, Can f 2, Can f 3, Can f 4, Can f 5 un Can f 6). Iegūtie dati tika analizēti kopā ar pacienta datiem par astmu un alerģisko rinītu. Rezultāti Molekulārā sensitizācija pret Can f 1, Can f 2 un Can f 6 uzrādīja statistiski nozīmīgu ietekmi uz astmas risku, taču, kad tika izslēgta sensitizācija pret citu dzīvnieku epitēliju, tikai Can f 1 un Can f 2 uzrādīja statistiski nozīmīgu ietekmi. Arī poz…

In vitro effects of AGNPs exopolysaccharide from Klebsiella Oxytoca DSM29614 on breast cancer cells

2015

Blends of Semiflexible Polymers: Interplay of Nematic Order and Phase Separation

2021

Mixtures of semiflexible polymers with a mismatch in either their persistence lengths or their contour lengths are studied by Density Functional Theory and Molecular Dynamics simulation. Considering lyotropic solutions under good solvent conditions, the mole fraction and pressure is systematically varied for several cases of bending stiffness κ (the normalized persistence length) and chain length N. For binary mixtures with different chain length (i.e., NA=16, NB=32 or 64) but the same stiffness, isotropic-nematic phase coexistence is studied. For mixtures with the same chain length (N=32) and large stiffness disparity (κB/κA=4.9 to 8), both isotropic-nematic and nematic-nematic unmixing oc…

Stick around: Cell–Cell Adhesion Molecules during Neocortical Development

2021

The neocortex is an exquisitely organized structure achieved through complex cellular processes from the generation of neural cells to their integration into cortical circuits after complex migration processes. During this long journey, neural cells need to establish and release adhesive interactions through cell surface receptors known as cell adhesion molecules (CAMs). Several types of CAMs have been described regulating different aspects of neurodevelopment. Whereas some of them mediate interactions with the extracellular matrix, others allow contact with additional cells. In this review, we will focus on the role of two important families of cell–cell adhesion molecules (C-CAMs), classi…

Stability, electronic structure, and optical properties of protected gold-doped silver Ag29−xAux (x = 0–5) nanoclusters

2017

In this work, we used density functional theory (DFT) and linear response time-dependent DFT (LR-TDDFT) to investigate the stability, electronic structure, and optical properties of Au-doped [Ag29-xAux(BDT)12(TPP)4]3- nanoclusters (BDT: 1,3-benzenedithiol; TPP triphenylphosphine) with x = 0-5. The aim of this work is to shed light on the most favorable doped structures by comparing our results with previously published experimental data. The calculated relative energies, ranging between 0.8 and 10 meV per atom, indicate that several doped Ag29-xAux nanoclusters are likely to co-exist at room temperature. However, only the Au-doped [Ag29-xAux(BDT)12(TPP)4]3- nanoclusters that have direct bon…

Recent Advances in the Chemistry of 1,2,4-Oxadiazoles

2015

1,2,4-Oxadiazoles experienced an almost 80-year long period of scientific lethargy before they tickled the curiosity of chemists. The study of chemical and photochemical reactivity of 1,2,4-oxadiazoles opened the way to a series of applications in heterocyclic synthesis. Today, 1,2,4-oxadiazoles are known in medicinal chemistry for their use as bioisosters of esters and amides. Furthermore, fluorinated 1,2,4-oxadiazoles have been applied in materials science either by themselves or for the targeted modification of polymers and macromolecules. Overall, the synthesis of 1,2,4-oxadiazoles can be planned to fine-tune their properties for featured applications. Their versatility, either as start…

THE ANTIOXIDANT PROPERTIES OF PHENOLIC MOLECULES IN RELATIONSHIP WITH THE pH OF ENVIRONMENT REACTION

2011

THE ANTIOXIDANT PROPERTIES OF PHENOLIC MOLECULES IN RELATIONSHIP WITH THE pH OF ENVIRONMENT REACTION Some epidemiological evidence suggests beneficial effects on human health from a diet rich in fruit, vegetables and certain types of beverages such as tea and wine (1,2). These compounds do not have nutritive properties but they have a functional role in the human organism. Some studies have investigated the effect of pH on the antioxidant properties of polyphenols (3,4) and have reported that the pH-dependent behaviour is related to hydroxyl deprotonation. However, these studies did not compare the antioxidant activity of various classes of polyphenols and did not take into account the acid…