Search results for "Molecules"

showing 10 items of 1147 documents

Human intestinal Vdelta1+ lymphocytes recognize tumor cells of epithelial origin.

1996

gammadelta T cells can be grouped into discrete subsets based upon their expression of T cell receptor (TCR) variable (V) region families, their tissue distribution, and their specificity. Vdelta2+ T cells constitute the majority of gammadelta T cells in peripheral blood whereas Vdelta1+T cells reside preferentially in skin epithelium and in the intestine. gammadelta T cells are envisioned as first line host defense mechanisms capable of providing a source of immune effector T cells and immunomodulating cytokines such as interleukin (IL) 4 or interferon (IFN) gamma. We describe here the fine specificity of three distinct gammadelta+ tumor-infiltrating lymphocytes (TIL) obtained from patient…

T cellMolecular Sequence DataImmunologySequence Homologychemical and pharmacologic phenomenaBiologyCell LineInterferon-gammaMiceInterleukin 21Lymphocytes Tumor-InfiltratingAntigens NeoplasmT-Lymphocyte SubsetsCulture TechniquesmedicineAnimalsHumansImmunology and AllergyCytotoxic T cellAmino Acid SequenceNeoplasms Glandular and EpithelialRNA MessengerIL-2 receptorAntigen-presenting cellLymphokine-activated killer cellBase SequenceInterleukin-7Receptors Antigen T-Cell gamma-deltaArticlesNatural killer T cellKidney NeoplasmsPancreatic Neoplasmsmedicine.anatomical_structureImmunologyCancer researchColorectal NeoplasmsCell Adhesion MoleculesCD8Interleukin-1Journal of Experimental Medicine
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Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains

Alzheimer’s disease (AD) is one of over 18 different disorders known as tauopathies, characterized by the pathological aggregation and accumulation of tau, a microtubule-associated protein. Tau aggregates are heterogeneous and can be divided into two major groups: large metastable neurofibrillary tangles (NFTs) and oligomers. Recently, it has been shown that tau oligomers are highly toxic in vitro and efficient seeds for the propagation of pathology as compared to NFTs. While the toxicity of recombinant tau oligomers has been studied extensively, within the same aggregation state, tau exhibits conformational differences, termed tau oligomeric strains. Due to the dynamic nature of these stra…

Tau aggregationSmall MoleculeToxicity.Tauopathies; Tau Oligomers; Tau aggregation; Small Molecules; Toxicity.TauopathieTau Oligomer
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Synthesis and helical supramolecular organization of discotic liquid crystalline dibenzo[hi,st]ovalene

2019

Dibenzo[hi,st]ovalene (DBOV) has emerged as a new polycyclic aromatic hydrocarbon (PAH) with intriguing optical properties with strong red emission. Nevertheless, DBOV derivatives thus far synthesized either had mesityl groups that hinder the pi-pi stacking of the aromatic cores or showed low solubility, and the self-assembly of DBOVs has not been investigated. In this work, two 3,4,5-tris(dodecyloxy)phenyl (TDOP) groups are introduced at the meso-positions of DBOV in order to enhance its solubility without compromising the intermolecular interactions. The obtained DBOV-TDOP forms at elevated temperatures a discotic liquid crystalline phase. Due to pi-pi-stacking interactions as well as loc…

TechnologyMaterials scienceMaterials ScienceStackingSupramolecular chemistryMaterials Science Multidisciplinary02 engineering and technologyOvalene010402 general chemistry01 natural sciencesPhysics Appliedchemistry.chemical_compoundHighly oriented pyrolytic graphitePhase (matter)Materials ChemistrySide chainCHARGE-TRANSPORTScience & TechnologyBilayerPhysicsHEXA-PERI-HEXABENZOCORONENESGeneral Chemistry021001 nanoscience & nanotechnology0104 chemical sciencesCrystallographychemistryMOBILITYPhysical SciencesAlkoxy groupDISK-LIKE MOLECULES0210 nano-technology
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Moringa oleifera Leaf Powder as Functional Additive in Cookies to Protect SH-SY5Y Cells

2021

The aim of this work is the evaluation of the addition of Moringa leaf powder (MLP) in cookies in terms of antioxidant properties, dough processability and sensorial properties of the cookies. The total content of biophenols and flavonoids in MLP was detected and the identification of the bioactive molecules was performed by HPLC-ESI-TOF-MS measurements, before and after oven treatment at 180 ◦C for 20 min. After a preliminary evaluation of the MLP water soluble fraction (MLPsf) cytotoxicity, its protective effect against an oxidative injury induced in the SH-SY5Y cells was assessed. Data evidence that the bioactive molecules present in MLPsf are effective in preventing ROS production and i…

TechnologySH-SY5YAntioxidantQH301-705.5QC1-999Bioactive moleculesmedicine.medical_treatmentCytotoxicitymedicine.disease_causeMORINGA OLEIFERA LEAFantioxidant effectsMoringachemistry.chemical_compoundHPLC-ESI-TOF-MS identificationsAntioxidant effects Cytotoxicity HPLC-ESI-TOF-MS identifications Moringa leaf powder Rheologymedicinemoringa leaf powderGeneral Materials ScienceOxidative injuryFood scienceBiology (General)QD1-999InstrumentationFluid Flow and Transfer ProcessesTPhysicsProcess Chemistry and TechnologyGeneral Engineeringfood and beveragesmoringa leaf powder; HPLC-ESI-TOF-MS identifications; cytotoxicity; antioxidant effects; rheology; SEMEngineering (General). Civil engineering (General)Moringa leaf powderComputer Science ApplicationsChemistrychemistryAntioxidant effectsSEMcytotoxicityrheologySettore CHIM/07 - Fondamenti Chimici Delle TecnologieTA1-2040KaempferolRheologyOxidative stress
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Correction: Mechanical properties of provisional dental materials: A systematic review and meta-analysis.

2018

Provisional restorations represent an important phase during the rehabilitation process, knowledge of the mechanical properties of the available materials allows us to predict their clinical performance. At present, there is no systematic review, which supports the clinicians’ criteria, in the selection of a specific material over another for a particular clinical situation. The purpose of this systematic review and meta-analysis was to assess and compare the mechanical properties of dimethacrylates and monomethacrylates used in fabricating direct provisional restorations, in terms of flexural strength, fracture toughness and hardness. This review followed the PRISMA guidelines. The searche…

TeethComputer sciencePolymerslcsh:MedicineChemical Composition02 engineering and technologycomputer.software_genre01 natural sciencesPolymerizationMathematical and Statistical TechniquesMedicine and Health Scienceslcsh:Science010302 applied physicsMultidisciplinaryChemical ReactionsResearch Assessment021001 nanoscience & nanotechnologyChemistryMacromoleculesMeta-analysisPhysical SciencesAnatomy0210 nano-technologyPlasticsNatural language processingStatistics (Mathematics)Research ArticleSystematic ReviewsMaterials by StructureMaterials ScienceMaterial PropertiesResearch and Analysis MethodsText mining0103 physical sciencesMechanical PropertiesStatistical MethodsMaterials by Attributebusiness.industrylcsh:RBiology and Life SciencesPolymer ChemistryJawlcsh:QArtificial intelligencebusinesscomputerDigestive SystemHeadMathematicsMeta-AnalysisPLoS ONE
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2,4-Di-tert-butyl-6-({[2-(di-methyl-amino)-eth-yl](2-hy-droxy-benz-yl)amino}-meth-yl)phenol.

2014

The title compound, C26H40N2O2, has both its N atoms in trigonal-pyramidal geometries. The molecular structure is stabilized by O—H...N and C—H...O hydrogen bonds. In the crystal, C—H...π interactions lead to the formation of a supramolecular helical chain along theb-axis direction.

Tert butylQuantitative Biology::BiomoleculesCrystallographyChemistryHydrogen bondSupramolecular chemistryGeneral ChemistryMeth-Condensed Matter PhysicsBioinformaticsMedicinal chemistryOrganic PapersHelical chainchemistry.chemical_compoundQD901-999PhenolGeneral Materials ScienceActa crystallographica. Section E, Structure reports online
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Rapid and eco-friendly synthesis of graphene oxide-silica nanohybrids

2014

The increasing interest in Graphene oxide (GO) is due to many issues: the presence of both sp2-conjugated atoms and oxygen-containing functional groups provides a strong hydrophilicity and the possibility to further functionalize it with other molecules (i.e. π-π interactions covalent attachment etc.) [1]. Furthermore since the GO is biocompatible and noncytotoxic many studies have been recently focused on the development of GO-based nanodevices for bioimaging DNA detection drug delivery. Due to their low cytotoxicity and large internal surface area silica nanoparticles have been taken into account as promising material for biolabeling and drug loading/delivery. Particular consideration has recently been demonstrated for GO-silica composites because of the potentialities for electrical applications their chemical inertia and stability toward ions exposure. The possibility to combine the extraordinary properties of GO and silica offers several advantages for the realization of nanoprobes for biological applications and of biosensor [12]. The strategy for the fabrication of GO-nanosilica nanohybrids can be schematized as follows: (i) synthesis of GO by oxidizing graphite powder with the method described by Marcano et al. [3] (ii) Preparation of oxygen-loaded silica nanoparticles by thermal treatments in controlled atmosphere in order to induce high NIR emission at 1272 nm from high purity silica nanoparticles. (iii) preparation of GrO-silica nanohybrid films via rapid solvent casting in water. The nanohybrids were tested by XPS FTIR Raman analysis UV photoluminescence analysis TGA Zeta potential measurements electrical tests AFM and SEM. Several nanohybrids were prepared by combining two different typologies of GO and two different samples of silica.
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DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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Computer Simulation Studies of Chain Dynamics in Polymer Brushes

2012

Center-of-mass and single monomer motion in grafted chains comprising a strongly stretched polymer brush in thermal equilibrium are studied by large scale molecular dynamics and Monte Carlo simulations of a coarse-grained model. Good solvent conditions are assumed. Our findings seriously question earlier theoretical predictions about the relaxation described by Rouse dynamics of brush coatings. Thus, the correlation functions of parallel and perpendicular components of the mean distance of the center-of-mass from the grafting site, the squared gyration radius and end-to-end distance, are found to deviate strongly from a simple exponential decay. While the relaxation times extracted from the…

Thermal equilibriumQuantitative Biology::BiomoleculesPolymers and PlasticsChemistryOrganic ChemistryMonte Carlo methodThermodynamicsRadiusPolymer brushGyrationCondensed Matter::Soft Condensed MatterInorganic ChemistryMolecular dynamicsComputational chemistryMaterials ChemistryRelaxation (physics)Exponential decayMacromolecules
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NanoMORALs: Metal Nanoparticles Doped with Organic Molecules

2009

A new class of nanosized metal–organic alloys (MORALs) has been synthesized for the first time. Silver nanoparticles doped with Cu(II) and Fe(III) phthalocyanines were thus synthesized in the presence of sodium dodecyl sulfate (SDS). The resulting materials were characterized by means of XRD, SEM, TEM coupled to energy dispersive X-ray analysis, and thermogravimetric analysis. No leaching of the photoactive dopant species was observed in water or in common organic solvents.

Thermogravimetric analysisDopantOrganic ChemistryInorganic chemistryDopingtechnology industry and agricultureGeneral ChemistryCatalysisSilver nanoparticleOrganic moleculeschemistry.chemical_compoundchemistryLeaching (metallurgy)Sodium dodecyl sulfateMetal nanoparticlesNuclear chemistry
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