Search results for "Mono"

DC specific Smad7 deficiency promotes differentiation of tolerogenic DCs able to attenuate EAE

2014

The immune network is a complex system for host defenses comprising various types of inflammatory and regulatory cells. Autoimmune diseases occur because of dysregulation in homeostasis caused by imbalance of these cells. The pattern of imbalance depends on the disease. Most autoimmune diseases are chronic, and the mechanism underlying this chronic nature is yet to be determined. Monoclonal antibody therapy is highly specific to the molecules targeted and is therefore highly effective. However, this therapy cannot be applied to all autoimmune diseases, and even the most effective therapy is incapable of completely inhibiting disease activity. Antigen-specific therapies have the ability to i…

Functional relevance of soluble TNF-alpha, transmembrane TNF-alpha and TNF-signal transduction in gastrointestinal diseases with special reference to…

2002

As a result of extensive clinical and basic research, the pivotal role of tumour necrosis factor (TNF) in the pathogenesis of chronic inflammatory diseases such as inflammatory bowel disease (IBD) has now generally been acknowledged. This has led to promising clinically effective anti-TNF-strategies. Of note, there is more and more evidence that TNF seems to play a key role in other gastrointestinal diseases including Helicobacter pylori infection, pancreatitis, viral hepatitis and toxic liver damage, too. The action of TNF at the cellular level is mediated by two cell surface receptors, TNF-R1 (p60) and TNF-R2 (p80). The function of these receptors and the downstream intracellular signal t…

Chronic Therapy with Isosorbide-5-Mononitrate Causes Endothelial Dysfunction and Oxidative Stress – Improvement by Endothelin-Receptor Blocker (Bosen…

2012

Mononeuropathy multiplex as a result of treatment with interferon-α and ribavirin in a patient with hepatitis C

2008

Oral manifestations and dental management of patient with leukocyte alterations

2011

Leukocytes are the main cellular elements of inflammatory and immune reactions of the organism. Leukocyte alterations are the consequence of an imbalance between the formation of leukocytes in the bone marrow and its elimination by the mononuclear phagocytic system. Factors that can modify leukopoyesis are varied and can lead to an alteration in the number of leukocytes or tumoral alterations of white cells (leukemias, lymphomas and plasma cell tumors). There is also a wide range of clinical manifestations that can derive from them: from very slight symptoms to life-threatening conditions. In some cases oral manifestations will be the first signs and it will be the dentist’s responsibility …

Response to Anti CD20 Monoclonal Antibody Rituximab® and Epitope Mapping of Inhibitory Antibodies in Patients with Acquired Haemophilia.

2006

Abstract Introduction: Acquired haemophilia (AcH) is associated with the development of polyclonal autoantibodies against FVIII, which affect directly the A2 or C2 domain of the FVIII molecule. Immunomodulatory therapy regimes to normalize FVIII levels and to eliminate the inhibitor are essential options in the treatment of patients (pts) with AcH. The aims of the present study were to investigate the response to Rituximab® and to localize the inhibitor epitopes on the FVIII domains. Patients and Methods: In 5 pts with AcH (2 females,3 males; age: 64–81 yrs) the inhibitor titers ranged from 9 to 156 BU and the FVIII activities from <1 % to 6 %. Rituximab® was administered once weekly…

Hyper-reticulated calixarene polymers: a new example of entirely synthetic nanosponge materials

2018

New calixarene-based nanosponges (CaNSs), i.e., hyper-reticulated polymers constituted by calixarene monomer units joined by means of bis(1,2,3-trialzolyl)alkyl linkers, were synthesized, characterized and subjected to preliminary tests to assess their supramolecular absorption abilities towards a set of suitable organic guests, selected as pollutant models. The synthesis was accomplished by means of a CuAAC reaction between a tetrakis(propargyloxy)calix[4]arene and an alkyl diazide. The formation of the polymeric network was assessed by means of FTIR and 13C{1H} CP-MAS solid-state NMR techniques, whereas morphological characterization was provided by SEM microghaphy. The materials were pro…

La reintroduzione del grano monococco (Triticum monococcum L)in Sicilia: risultati di un'analisi preliminare delle caratteristiche agronomiche e qual…

2011

Il grano monococco (Triticum monococcum L.), conosciuto come “farro piccolo”, è una specie diploide con genoma A (2n=2x=14), le cui cariossidi, anche dopo trebbiatura, si presentano rivestite dalle glume. Insieme a farro ed orzo, dal Neolitico fino al termine dell’età del Bronzo (900 a.C.), è stato alla base della dieta delle popolazioni mediterranee, per essere poi sostituito dal più produttivo farro (T. dicoccum) e successivamente completamente dimenticato. Il crescente consumo di alimenti con caratteristiche dietetico-nutrizionali elevate, unito alla possibilità di introdurre nel panorama cerealicolo siciliano una coltura mai sperimentata prima, ci ha indirizzato nella realizzazione di u…

Carbohydrates as Chemical Constituents of Biowaste Composts and their Humic and Fulvic Acids

1995

The decomposition of organic matter of source-separated biowaste during composting was followed during 18 months. Compost samples were fractionated into three parts: (i) hot water soluble extract (HWE) (ii) bitumen fraction and (iii) humic substances (humic acids (HA) and fulvic acids (FA)). Original compost samples and the HA and FA fractions were hydrolyzed with sulfuric acid for hexoses and pentoses. Quantitative spectrophotometric and qualitative GC/MS analyses of monosaccharides as trimethylsilyl ethers of the corresponding alditols were carried out.During composting, the amount of HA in the organic matter of the compost increased, the amounts of HWE and bitumen decreased and the amoun…

Terapia orale domiciliare per il paziente con il carcinoma prostatico ormonorefrattario.

2008

TERAPIA ORALE DOMICILIARE PER IL PAZIENTE CON CARCINOMA PROSTATICO ORMONOREFRATTARIO V. Altieri, V. Serretta, D. Melloni, R. Allegro, G. Morgia, M. Madonia, M. Ferro, A. Siragusa, G. De Grande, L. Orestano, M. Napoli, E. Membri Fondazione GSTU (Napoli) SCOPO DEL LAVORO: Per preservare la qualità di vita del paziente affetto da carcinoma prostatico ormonorefrattario (HRPC) si rendono necessari regimi terapeutici che possano essere eseguiti a domicilio senza frequenti ricoveri ospedalieri, seppur in regime di dayhospital. I vantaggi in termini di sopravvivenza offerti da schemi chemioterapici a base di taxani, pur presenti, sono ad oggi limitati. Scopo del presente studio di fase II è stato q…