Search results for "Morphisms"
showing 10 items of 190 documents
BCL2 gene polymorphisms and splicing variants in chronic myeloid leukemia.
2015
Recent data suggest that constitutional genetic variation in the antiapoptotic BCL2 gene could be associated with the susceptibility to develop chronic myeloid leukemia (CML) and the clinical outcome in several hematological malignancies. The present study examines whether BCL2 single nucleotide polymorphisms (SNPs) predispose to CML or may potentially influence the disease characteristics at diagnosis. Notably, no association was observed between the four candidate BCL2 SNPs and the risk of developing CML. Instead, the 4777C>A (rs2279115) and the 5735A>G (rs1801018) SNPs were significantly associated with the disease risk profile as determined by the Sokal score. We found that such polymor…
Interacciones dieta-genotipo entre el consumo de grasas y polimorfismos comunes determinando el metabolismo lipídico
2009
Las recomendaciones dietéticas actuales referentes al consumo de grasas en la dieta han sido realizadas sin tener en cuenta las posibles diferencias genéticas de las personas que podrían ser las responsables de las diferentes respuestas interindividuales que frecuentemente se observan ante la misma dieta. La presencia de variabilidad genética ha sido puesta de manifiesto para todos los genes relacionados con el metabolismo lipídico, por lo que existe un ingente número de genes y de variantes genéticas para ser incluidas en los estudios sobre interacciones dieta-genotipo en el ámbito específico del consumo de grasas y aceites. Se revisarán algunos ejemplos sobre interacciones grasa-genotipo.…
Genetic instability in calamondin (Citrus madurensis Lour.) plants derived from somatic embryogenesis induced by diphenylurea derivative
2007
Somatic embryos were regenerated in vitro from calamondin style-stigma explants cultured in the presence of N (6)-benzylaminopurine (BAP) cytokinin and three synthetic phenylurea derivatives, N-(2-chloro-4-pyridyl)-N-phenylurea (4-CPPU), N-phenyl-N'-benzothiazol-6-ylurea (PBU) and N,N'-bis-(2,3-methilendioxyphenyl)urea (2,3-MDPU). The phenylurea derivative compounds tested at micromolar level (12 muM) were able to induce a percentage of responsive explants significantly higher from that obtained with BAP and hormone-free (HF) conditions. In order to verify the genetic stability of the regenerants, 27 plants coming from different embryogenic events were randomly selected from each different …
The Correlation Between Abnormal Uterine Artery Flow in the First Trimester and Genetic Thrombophilic Alteration: A Prospective Case-Controlled Pilot…
2020
Introduction. Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications. A genotype, making women prone to microthrombi. constitutes the main known susceptibility factor for anomalous development of placenta. Our aim was to study whether polymorphisms of 10 genes leading to blood clotting abnormalities are related to abnormal uterine artery blood flow in the first trimester, and may predict placenta-related diseases. Material and methods. In primary analyses we included 19 singleton pregnancies with abnormal blood flow in the uterine arteries during the first trimester of gestation, and 24 matched control with normal flow patterns. All pa…
Polymorphism of cytochrome P450 (CYP) genes and response to chemiotherapy in patients with colorectal cancer (CRC)
2014
Background: Genes coding for the cytochrome P450 (CYP) enzyme system implied in antineoplastic drug metabolism pathways are highly polymorphic. This may influence both carcinogen metabolism and drug pharmacodynamics modifying their therapeutic efficacy and side effects. Methods: We investigated the influence of genetic polymorphisms of CYP enzymes: rs1799853 (CYP2C9), rs35742686 (CYP2D), rs5030655 (CYP2D6/3), rs2740574 (CYP3A4/1) rs776746 (CYP3A5) on the response of chemotherapy and clinical outcomes, in a group of 56 patients affected by sporadic CRC, treated with the standard protocols. A total of 44 patients were in complete remission after treatment, 12 had persistence of the disease. P…
Automorphisms of the integral group ring of the hyperoctahedral group
1990
The purpose of this paper is to verify a conjecture of Zassenhaus [3] for hyperoctahedral groups by proving that every normalized automorphism () of ZG can be written in the form () = Tu 0 I where I is an automorphism of ZG obtained by extending an automorphism of G linearly to ZG and u is a unit of (JJG. A similar result was proved for symmetric groups by Peterson in [2]; the reader should consult [3] or the survey [4] for other results of this kind. 1989
Transitive factorizations in the hyperoctahedral group
2008
The classical Hurwitz enumeration problem has a presentation in terms of transitive factor- izationsin the symmetric group. This presentationsuggestsageneralizationfromtypeAto otherfinite reflection groups and, in particular, to type B.W e study this generalization both from ac ombinatorial and a geometric point of view, with the prospect of providing am eans of understanding more of the structure of the moduli spaces of maps with an S2-symmetry. The type A case has been well studied and connects Hurwitz numbers to the moduli space of curves. W ec onjecture an analogous setting for the type B case that is studied here. 1I ntroduction Transitive factorizations of permutations into transposit…
Cyclotomic Polynomials and Finite Automorphisms of Groups
2001
We introduce minimal polynomials for finite automorphisms of commutative groups and relate them to the exponent of the fixed points and to the reducibility of the group. Some results can be extended to the noncommutative case.
Limits of Sobolev homeomorphisms
2017
Let X; Y subset of R-2 be topologically equivalent bounded Lipschitz domains. We prove that weak and strong limits of homeomorphisms h: X (onto)-> Y in the Sobolev space W-1,W-p (X, R-2), p >= 2; are the same. As an application, we establish the existence of 2D-traction free minimal deformations for fairly general energy integrals. Peer reviewed
Irreducible components of Hurwitz spaces parameterizing Galois coverings of curves of positive genus
2014
Let Y be a smooth, projective, irreducible complex curve. A G-covering p : C → Y is a Galois covering, where C is a smooth, projective, irreducible curve and an isomorphism G ∼ −→ Aut(C/Y ) is fixed. Two G-coverings are equivalent if there is a G-equivariant isomorphism between them. We are concerned with the Hurwitz spaces H n (Y ) and H G n (Y, y0). The first one parameterizes Gequivalence classes of G-coverings of Y branched in n points. The second one, given a point y0 ∈ Y , parameterizes G-equivalence classes of pairs [p : C → Y, z0], where p : C → Y is a G-covering unramified at y0 and z0 ∈ p (y0). When G = Sd one can equivalently consider coverings f : X → Y of degree d with full mon…