Search results for "Motif"
showing 10 items of 290 documents
EGFL7 ligates αvβ3 integrin to enhance vessel formation
2013
Angiogenesis, defined as blood vessel formation from a preexisting vasculature, is governed by multiple signal cascades including integrin receptors, in particular integrin αVβ3. Here we identify the endothelial cell (EC)-secreted factor epidermal growth factor-like protein 7 (EGFL7) as a novel specific ligand of integrin αVβ3, thus providing mechanistic insight into its proangiogenic actions in vitro and in vivo. Specifically, EGFL7 attaches to the extracellular matrix and by its interaction with integrin αVβ3 increases the motility of EC, which allows EC to move on a sticky underground during vessel remodeling. We provide evidence that the deregulation of EGFL7 in zebrafish embryos leads …
A peptide inhibiting the collagen binding function of integrin alpha2I domain.
1999
Integrin alpha2 subunit forms in the complex with the beta1 subunit a cell surface receptor binding extracellular matrix molecules, such as collagens and laminin-1. It is a receptor for echovirus-1, as well. Ligands are recognized by the special "inserted" domain (I domain) in the integrin alpha2 subunit. Venom from a pit viper, Bothrops jararaca, has been shown to inhibit the interaction of platelet alpha2beta1 integrin with collagen because of the action of a disintegrin/metalloproteinase named jararhagin. The finding that crude B. jararaca venom could prevent the binding of human recombinant ralpha2I domain to type I collagen led us to study jararhagin further. Synthetic peptides represe…
Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo
2015
Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here, we show that Hox proteins are able to interact with a wide range of transcription factors in the live Drosophila embryo. In this context, specificity relies on a versatile usage of conserved short linear motifs (SLiMs), which, surprisingly, often restrains the interaction potential of Hox proteins. This novel buffering activity of SLiMs was observed in different tissues and found in Hox proteins from cnidarian to mouse species. Although th…
γ2-Adaptin, a Ubiquitin-interacting Adaptor, Is a Substrate to Coupled Ubiquitination by the Ubiquitin Ligase Nedd4 and Functions in the Endosomal Pa…
2008
gamma2-Adaptin is a putative member of the clathrin adaptor protein family with unknown physiological function. We previously reported that gamma2-adaptin acts as a ubiquitin receptor by virtue of its ubiquitin-interacting motif. Here we demonstrate that this motif mediates a specific physical interaction with the ubiquitin ligase Nedd4 and promotes ubiquitination of gamma2-adaptin. By mapping regions of Nedd4 involved in binding to gamma2-adaptin, we identified its C2 domain to be essential, whereas the WW and HECT domains are dispensable. Consistent with this, we uncovered that the C2 domain of Nedd4 is ubiquitinated itself and as such is recruited by the ubiquitin-interacting motif of ga…
Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth.
2021
We would like to thank all the families that participated in these studies for their generous contribution. Detailed acknowledgements and funding can be found in Sup plementary Material.
The influence study of the number of substituted heteroaryls at the non-K region of pyrene structure on the photophysical properties based on the exa…
2022
The study of the photophysical properties (thermal - thermogravimetric analysis and optical - absorption, emission in the solution and in powder, quantum efficiency of emission and efficient fluorescence lifetime in the solution) with the focus on the influence of the number of substituted 1-decyl-1H-1,2,3-triazole groups at the non-K region of pyrene structure. To the best of our knowledge, the investigation of the impact of the number of heteroaryl groups at the non-K region of pyrene is reported for the first time. The obtained results for monosubstituted derivative (1) were compared to di- (2, 3) and tetra- (4) analogues previously reported by us in the literature. In addition, theoreti…
Statistically validated mobile communication networks: the evolution of motifs in European and Chinese data
2014
Big data open up unprecedented opportunities to investigate complex systems including the society. In particular, communication data serve as major sources for computational social sciences but they have to be cleaned and filtered as they may contain spurious information due to recording errors as well as interactions, like commercial and marketing activities, not directly related to the social network. The network constructed from communication data can only be considered as a proxy for the network of social relationships. Here we apply a systematic method, based on multiple hypothesis testing, to statistically validate the links and then construct the corresponding Bonferroni network, gen…
Des Fioretti aux Lais. Villon : une poétique de l’ascèse et du dessaisissement
2019
International audience; No abstract
2D motif basis applied to the classification of digital images
2016
The classification of raw data often involves the problem of selecting the appropriate set of features to represent the input data. Different types of features can be extracted from the input dataset, but only some of them are actually relevant for the classification process. Since relevant features are often unknown in real-world problems, many candidate features are usually introduced. This degrades both the speed and the predictive accuracy of the classifier due to the presence of redundancy in the set of candidate features. Recently, a special class of bidimensional motifs, i.e. 2D motif basis has been introduced in the literature. 2D motif basis showed to be powerful in capturing the r…
Motif patterns in 2D
2008
AbstractMotif patterns consisting of sequences of intermixed solid and don’t-care characters have been introduced and studied in connection with pattern discovery problems of computational biology and other domains. In order to alleviate the exponential growth of such motifs, notions of maximal saturation and irredundancy have been formulated, whereby more or less compact subsets of the set of all motifs can be extracted, that are capable of expressing all others by suitable combinations. In this paper, we introduce the notion of maximal irredundant motifs in a two-dimensional array and develop initial properties and a combinatorial argument that poses a linear bound on the total number of …