Search results for "Motif"
showing 10 items of 290 documents
Mo-Based Oxidizers as Powerful Tools for the Synthesis of Thia- and Selenaheterocycles.
2019
A highly efficient synthetic protocol for the synthesis of thia- and selenaheterocycles has been developed. By employing a MoCl5 -mediated intramolecular dehydrogenative coupling reaction, a broad variety of structural motifs was isolated in yields up to 94 %. The electrophilic key transformation is tolerated by several labile moieties like halides and tertiary alkyl groups. Due to the use of disulfide or diselenide precursors, a high atom efficiency was achieved.
The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects
2010
Contains fulltext : 96400.pdf (Publisher’s version ) (Closed access) Intelligence is a highly heritable trait for which it has proven difficult to identify the actual genes. In the past decade, five whole-genome linkage scans have suggested genomic regions important to human intelligence; however, so far none of the responsible genes or variants in those regions have been identified. Apart from these regions, a handful of candidate genes have been identified, although most of these are in need of replication. The recent growth in publicly available data sets that contain both whole genome association data and a wealth of phenotypic data, serves as an excellent resource for fine mapping and …
Dynamics of brain activity underlying working memory for music in a naturalistic condition
2012
Working memory (WM) is at the core of any cognitive function as it is necessary for the integration of information over time. Despite WM’s critical role in high-level cognitive functions, its implementation in the neural tissue is poorly understood. Preliminary studies on auditory WM show differences between linguistic and musical memory, leading to the speculation of specific neural networks encoding memory for music. Moreover, in neuroscience WM has not been studied in naturalistic listening conditions but rather in artificial settings (e.g., n-back and Sternberg tasks). Western tonal music provides naturally occurring motivic repetition and variation, recognizable units serving as WM tri…
Parsimonious scenario for the emergence of viroid-like repliconsde novo
2019
AbstractViroids are small, non-coding, circular RNA molecules that infect plants. Different hypotheses for their evolutionary origin have been put forward, such as an early emergence in a precellular RNA World or severalde novoindependent evolutionary origins in plants. Here we discuss the plausibility ofde novoemergence of viroid-like replicons by giving theoretical support to the likelihood of different steps along a parsimonious evolutionary pathway. While Avsunviroidae-like structures are relatively easy to obtain through evolution of a population of random RNA sequences of fixed length, rod-like structures typical of Pospiviroidae are difficult to fix. Using different quantitative appr…
L‐Aspartate as a high‐quality nitrogen source in Escherichia coli : Regulation of L‐aspartase by the nitrogen regulatory system and interaction of L‐…
2020
Escherichia coli uses the C4-dicarboxylate transporter DcuA for L-aspartate/fumarate antiport, which results in the exploitation of L-aspartate for fumarate respiration under anaerobic conditions and for nitrogen assimilation under aerobic and anaerobic conditions. L-Aspartate represents a high-quality nitrogen source for assimilation. Nitrogen assimilation from L-aspartate required DcuA, and aspartase AspA to release ammonia. Ammonia is able to provide by established pathways the complete set of intracellular precursors (ammonia, L-aspartate, L-glutamate, and L-glutamine) for synthesizing amino acids, nucleotides, and amino sugars. AspA was regulated by a central regulator of nitrogen meta…
Human Enterovirus Group B Viruses Rely on Vimentin Dynamics for Efficient Processing of Viral Nonstructural Proteins.
2019
A virus needs the host cell in order to replicate and produce new progeny viruses. For this, the virus takes over the host cell and modifies it to become a factory for viral proteins. Irrespective of the specific virus family, these proteins can be divided into structural and nonstructural proteins. Structural proteins are the building blocks for the new progeny virions, whereas the nonstructural proteins orchestrate the takeover of the host cell and its functions. Here, we have shown a mechanism that viruses exploit in order to regulate the host cell. We show that viral protein synthesis induces vimentin cages, which promote production of specific viral proteins that eventually control apo…
MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation
2019
Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used. In our recent studies, we identified two miRNAs as regulators of hMSCs osteoblast differentiation driving hypoxia signaling and cytoskeletal reorganization. Other signalings involved in this process are epithelial to mesenchymal transition (EMT) and epidermal growth factor receptor (EGFR) signalings through the regulation of Yes-associated protein (YAP)/PDZ-binding motif (TAZ) expression. In the current study, we investigated the role of miR-33a family as a (…
F-type lectin from the sea bass (Dicentrarchus labrax): purification, cDNA cloning, tissue expression and localization, and opsonic activity.
2009
Recently described biochemical and structural aspects of fucose-binding lectins from the European eel (Anguilla anguilla) and striped bass (Morone saxatilis) led to the identification of a novel lectin family ("F-type" lectins) characterized by a unique sequence motif and a characteristic structural fold. The F-type fold is shared not only with other members of this lectin family, but also with apparently unrelated proteins ranging from prokaryotes to vertebrates. Here we describe the purification, biochemical and molecular properties, and the opsonic activity of an F-type lectin (DlFBL) isolated from sea bass (Dicentrarchus labrax) serum. DlFBL exhibits two tandemly arranged carbohydrate-r…
Consistency tendency and the theory of planned behavior : a randomized controlled crossover trial in a physical activity context
2020
Objective: This study examined the effects of consistency tendency on the predictive power of the theory of planned behavior (TPB) in relation to physical activity behavior. Methods: In this randomized controlled cross-over trial, we recruited 770 undergraduate students from Indonesia who were randomly assigned into two groups. Participants completed physical activity versions of TPB measures at T1 (baseline) and T2 (post 1 week), and the International Physical Activity Questionnaire at T3 (post 1 month). At T1 and T2, the TPB questions were either presented in ensemble-order (i.e., consistency tendency supressed) or alternate-order (i.e., consistency tendency facilitated). Results: The par…
La elección de los grados de Maestro/a: análisis de tendencias e incidencia del género y la titulación
2021
La elección de estudios universitarios es un proceso complejo en el que influyen diferentes variables. En este estudio se analizan los motivos de elección de carrera del alumnado de los Grados de Maestro/a en Educación Infantil y Educación Primaria de la Universitat de València en la última década, así como las posibles diferencias en los motivos a lo largo del tiempo y en función del Grado y del sexo. Utilizando como instrumento de recogida de información, un cuestionario adaptado de otra investigación en el contexto español, se analizan las motivaciones de un total de 769 estudiantes de estas titulaciones, recogidas en tres tiempos (cursos: 2010-2011, 2014-2015 y 2018-2019). Los resultado…