6533b834fe1ef96bd129e009

RESEARCH PRODUCT

Mo-Based Oxidizers as Powerful Tools for the Synthesis of Thia- and Selenaheterocycles.

Siegfried R. WaldvogelSebastian B. BeilDieter SchollmeyerPeter Franzmann

subject

chemistry.chemical_classificationcyclization010405 organic chemistryChemistryoxidationOrganic ChemistryHalideGeneral Chemistry010402 general chemistry01 natural sciencesCombinatorial chemistryCatalysisCoupling reactionC−H activationsulfur heterocycles0104 chemical sciencesDiselenidemolybdenumAtom economyIntramolecular forceElectrophileStructural motifAlkyl

description

A highly efficient synthetic protocol for the synthesis of thia- and selenaheterocycles has been developed. By employing a MoCl5 -mediated intramolecular dehydrogenative coupling reaction, a broad variety of structural motifs was isolated in yields up to 94 %. The electrophilic key transformation is tolerated by several labile moieties like halides and tertiary alkyl groups. Due to the use of disulfide or diselenide precursors, a high atom efficiency was achieved.

yearjournalcountryeditionlanguage
2019-02-06Chemistry (Weinheim an der Bergstrasse, Germany)
10.1002/chem.201805938https://pubmed.ncbi.nlm.nih.gov/30537384