Search results for "Motor activity"
showing 10 items of 486 documents
Therapeutic-like properties of a dopamine uptake inhibitor in animal models of amphetamine addiction.
2010
N-substituted benztropine (BZT) analogs are molecules that display high affinity for the dopamine transporter (DAT), therapeutic-like effects in animal models of cocaine abuse, and psychopharmacological characteristics consistent with those of a substitute medication for cocaine addiction. Since amphetamine (Amph) and cocaine share mechanisms of action at the DAT, we evaluated the effectiveness of a BZT analog in animal models of Amph addiction. We tested in mice and rats the effects of the BZT derivative, 3α-[bis(4-fluorophenyl)methoxy]-tropane (AHN-1055), on Amph-induced conditioned place preference (CPP), locomotor activity, sensitization, self-administration and ΔFosB accumulation in th…
Procjena životnog stila mladih žena smanjene, normalne i prekomjerne tjelesne težine
2013
The aim of this study was to compare eating and lifestyle habits between underweight, normal weight and overweight young women. Data obtained from a survey of 1129 students of the three higher education institutions in Kielce, Kraków and Opole (Southern Poland) were analysed. BMI was used to define underweight, overweight and obesity. Eating and lifestyle habits were assessed based on the information received from surveyed students. The study group consisted of women of childbearing-age and a special attention was paid to analyse habits correlated with the risk factor for pregnant women (low consumption of dairy products, meat, fish, fruits and vegetables, cigarette smoking, alcohol and caf…
Cytopathologic and neurochemical correlates of progression to motor/cognitive impairment in SIV-infected rhesus monkeys.
1994
Neurochemical, pathologic, virologic, and histochemical correlates of simian immunodeficiency virus (SIV)-associated central nervous system (CNS) dysfunction were assessed serially or at necropsy in rhesus monkeys that exhibited motor and cognitive deficits after SIV infection. Some infected monkeys presented with signs of acquired immunodeficiency disease (AIDS) at the time of sacrifice. Seven of eight animals exhibited motor skill impairment which was associated with elevated quinolinic acid in cerebrospinal fluid (CSF). Examination of the brains revealed diffuse increases in glial fibrillary acidic protein immunoreacti vity in cerebral cortex in all animals, regardless of evidence of imm…
Time scales of adaptive behavior and motor learning in the presence of stochastic perturbations.
2009
In this paper, the major assumptions of influential approaches to the structure of variability in practice conditions are discussed from the perspective of a generalized evolving attractor landscape model of motor learning. The efficacy of the practice condition effects is considered in relation to the theoretical influence of stochastic perturbations in models of gradient descent learning of multiple dimension landscapes. A model for motor learning is presented combining simulated annealing and stochastic resonance phenomena against the background of different time scales for adaptation and learning processes. The practical consequences of the model's assumptions for the structure of pract…
Towards the integration and development of a cross-European research netwerk and infrastructure : the DEterminants of Diet and Physical ACtivity (DED…
2014
To address major societal challenges and enhance cooperation in research across Europe, the European Commission has initiated and facilitated ‘joint programming’. Joint programming is a process by which Member States engage in defining, developing and implementing a common strategic research agenda, based on a shared vision of how to address major societal challenges that no Member State is capable of resolving independently. Setting up a Joint Programming Initiative (JPI) should also contribute to avoiding unnecessary overlap and repetition of research, and enable and enhance the development and use of standardised research methods, procedures and data management. The Determinants of Diet …
Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and func…
2016
ABSTRACT Mutations in Drosophila Swiss cheese (SWS) or its vertebrate orthologue neuropathy target esterase (NTE), respectively, cause progressive neuronal degeneration in Drosophila and mice and a complex syndrome in humans that includes mental retardation, spastic paraplegia and blindness. SWS and NTE are widely expressed in neurons but can also be found in glia; however, their function in glia has, until now, remained unknown. We have used a knockdown approach to specifically address SWS function in glia and to probe for resulting neuronal dysfunctions. This revealed that loss of SWS in pseudocartridge glia causes the formation of multi-layered glial whorls in the lamina cortex, the firs…
Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population
2012
Objective To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean population. Methods We studied 3 independent adult samples: a random sample (n = 1580) from the general population (GP), obese hospital patients (OHP) (n = 203) and elderly subjects (n = 1027) with high cardiovascular risk (HCR). Weight and height were directly measured. Education and physical activity (PA) were measured using questionnaires. Results The rs9939609 presented heterogeneous associations with BMI. In the GP, the minor A-allele was significantly associated wit…
DETERMINATION OF MAXIMAL FAT OXIDATION FOR PRESCRIBING EXERCISE IN SEDENTARY NON-OBESE TYPE 2 DIABETES SUBJECTS
2014
Aim: To determine the exercise intensity that elicits the highest fat oxidation rate in sedentary non-obese subjects with type 2 diabetes. Methods: Eleven sedentary subjects with type 2 diabetes (T2DS) and eleven healthy sedentary subjects (HS), aged 45 to 65 and non-obese, were evaluated to a graded exercise test. Oxygen uptake (VO2) and fat oxidation rate (FAT) were detected. FAT was then plotted as a function of exercise intensity, expressed as percentage of VO2max. We determined the exercise intensity (%VO2max) at which fat oxidation was maximal (FATmax). Results: Absolute FATmax was not significantly different between T2DS and HS (0.51 0.13 vs. 0.56 0.29 g∙min-1). FATmax occurred a…
Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort.
2002
Extracts of the medicinal plant St. John's wort (Hypericum perforatum) are widely used for the treatment of mild to moderate depression. Hyperforin, a constituent of St. John's wort, is known to inhibit the sodium-dependent uptake of catecholamines and amino acids into synaptic nerve endings, probably by interference with mechanisms controlling the synaptic sodium concentration. Because de novo synthesis of acetylcholine (ACh) is dependent on sodium-dependent high-affinity choline uptake, we studied the effect of hyperforin on choline (Ch) uptake in vitro and on striatal ACh release in vivo using microdialysis. In rat brain synaptosomes, hyperforin inhibited high-affinity choline uptake wit…
Kinesiophobia Levels in Patients with Parkinson’s Disease: A Case-Control Investigation
2021
Background: Kinesiophobia can be an obstacle to physical and motor activity in patients with Parkinson’s disease (PD). PD affects patients’ independence in carrying out daily activities. It also impacts a patient’s biopsychosocial well-being. The objective of this study was to analyze the levels and scores of kinesiophobia in PD patients and compare them with healthy volunteers. Methods: We deployed a case-control study and recruited 124 subjects (mean age 69.18 ± 9.12). PD patients were recruited from a center of excellence for Parkinson’s disease (cases n = 62). Control subjects were recruited from the same hospital (control n = 62). Kinesiophobia total scores and categories were self-rep…