Search results for "Move"
showing 10 items of 2153 documents
Instruction of Digital Reading Strategies Based on Eye-Movements Modeling Examples
2018
During the last decade, several studies have proposed and tested different instructional methods for teaching digital reading strategies to young students. In this study, we have tested the effectiveness of a program combining eye-movements modeling examples (EMMEs) and contrasting cases to instruct ninth-grade students how to plan, evaluate, and monitor their digital reading. EMMEs are videos that display a dot representing the eye movements of a model and an oral transcription of her thoughts while answering a specific question in a hypertext. Students in the EMME condition obtain higher comprehension scores in a posttest performed 1 week after the instruction, as compared with a control…
A model study for the progressive disruption of CA1 firing properties during Alzheimer’s disease
2011
Several independent studies show that β-Amyloid (Aβ) peptides accumulation, one of the characteristic hallmark of Alzheimer’s Disease (AD), can affect the normal neuronal activity in different ways causing an increase or a decrease in neuronal membrane excitability. For example, experimental evidence for a negative impact on neuronal membrane in animal models of AD has been obtained in dual patch recordings in rat hippocampal tissue slices, in which Aβ blocked K channels in pyramidal cell dendrites, causing an increase in dendritic membrane excitability. The resulting increased Ca2+ influx and excitoxicity may lead to dendritic degeneration. However, further experimental evidence suggests t…
From the Blogosphere into Real Politics: The Use of ICT by the Five Star Movement
2014
Research on ICT and the public discourse often focuses on how ICT can be used to increase citizen participation in political decision-making processes. The Italian Five Star Movement (5SM) represents a novel approach to using ICT to include citizens, and a big challenge for the traditional political actors. The 5SM was initiated outside the established political systems, with the use of Internet tools as cornerstones to promote political actions based on the directly expressed will of citizens. In this paper, based on an exploratory case study approach and informed by the introduction of E-Democracy models, we investigate the role of ICT in various phases of the 5SM, from its birth through …
Opioid-Sensitive Peripheral Neuronal Activity in the Modulation of Gastric Mucosal Injury
1991
There is growing evidence that capsaicin-sensitive afferent neurones participate in the protective mechanisms of the gastric mucosa against damage. Animals pretreated systemically with capsaicin, at doses that lead to the ablation of capsaicin-sensitive afferent neurons, show an increase in the level of macro-scopically apparent mucosal damage in different experimental models of ulceration (Szolcsanyi and Bartho, 1981; Holzer and Sametz, 1986). Furthermore, acute stimulation with capsaicin of afferent nerve endings located in the gastric mucosa protects against different ulcerogenic mechanisms (Szolcsanyi and Bartho, 1981; Holzer and Lippe, 1988; Holzer et al., 1989).
In-house versus external basic research and first-to-market innovations
2016
This paper explores to what extent conducting internal basic research, as opposed to external basic research (i.e. outsourcing and collaboration with universities) encourages firms to bring new products into the market ahead of competitors, and contributes to innovation performance. The analysis is based on a sample of Spanish manufacturing firms over the period 2006–2012. Our findings suggest that conducting in-house basic research affects firm's propensity to introduce product novelties. Furthermore, performing this activity continuously affects the probability of being product-pioneer in low and medium–low tech sectors. Collaboration with universities also helps in introducing new produc…
BIOPHARMACEUTICAL ALLIANCES AND COMPETITION: A REAL OPTIONS GAMES APPROACH
2013
The competitive landscape where pharmaceutical and biotechnology companies operate has changed radically due to a scientific/technological progress that has revolutionised the process by which drugs are developed. In fact, pharmaceutical industry more and more relies on advances in biochemistry and molecular biology. As a consequence, the number of partnerships between pharmaceutical and biotech firms has grown significantly. Research contributions addressing the biopharmaceutical alliances design have also focused on the optimal timing to sign a partnership. In this paper, we introduce and analyse the effect of competition in biotechnology industry by modelling the decisions of whether and…
Tensions in Online Communities: The Case of a Mass Size eParticipation Initiative
2017
Part 4: Critical Reflections; International audience; While Online Communities (OCs) are increasingly used to involve people in organizations and societies, few studies focus on how OC influence political decision making within eParticipation initiatives. This issue is explored through an interpretive case-study of the Italian Five Star Movement (M5S), a mass-size eParticipation political initiative recently founded by private citizens. The use of OCs is a common strategy to involve groups of people to easily connect on-line, cooperating on common and shared interests. We here focus on understanding the internal and external forces influencing on the OCs, to better understand how to manage …
Las organizaciones solidarias un análisis de su naturaleza y significado a la luz del caso valenciano
2018
Las organizaciones de voluntariado están recibiendo una creciente atención por parte de los analistas de la acción colectiva. Para unos, en su fulgurante auge reciente, se manifiesta la estrategia privatizadora del Estado de Bienestar; para otros, son expresión de un nuevo movimiento social. En este artículo los autores utilizan la amplia evidencia reunida en el caso valenciano, mediante distintas estrategias de exploración (entrevistas abiertas, encuestas, análisis de casos), para someter a examen dichas tesis. El resultado obtenido muestra más bien la heterogeneidad, disparidad y diversidad de organizaciones existentes, su reducido tamaño de recursos y su exigua articulación interna. Los …
Cyclotriveratrylene-Containing Porphyrins
2016
International audience; The C-3-symmetric cyclotriveratrylene (CTV) was covalently bonded via click chemistry to 1, 2, 3, and 6 zinc(II) porphyrin units to various host for C-60. The binding constants, Ka, were measured from the quenching of the porphyrin fluorescence by C-60. These constants vary between 400 and 4000 M-1 and are considered weak. Computer modeling demonstrated that the zinc(II) porphyrin units, [Zn], exhibit a strong tendency to occupy the CTV cavity, hence blocking the access for C-60 to land on this site. Instead, the pincer of the type [Zn]-[Zn] and in one case [Zn]-CTV, were found to be the most probable geometry to promote host-guest associations in these systems.
MicroRNA-29b-1 impairs in vitro cell proliferation, self‑renewal and chemoresistance of human osteosarcoma 3AB-OS cancer stem cells
2014
Osteosarcoma (OS) is the most common type of bone cancer, with a peak incidence in the early childhood. Emerging evidence suggests that treatments targeting cancer stem cells (CSCs) within a tumor can halt cancer and improve patient survival. MicroRNAs (miRNAs) have been implicated in the maintenance of the CSC phenotype, thus, identification of CSC-related miRNAs would provide information for a better understanding of CSCs. Downregulation of miRNA-29 family members (miR-29a/b/c; miR‑29s) was observed in human OS, however, little is known about the functions of miR-29s in human OS CSCs. Previously, during the characterization of 3AB-OS cells, a CSC line selected from human OS MG63 cells, we…