Search results for "Movement"

s ‐Triazine pincer ligands: Synthesis of their metal complexes, coordination behavior, and applications

2021

Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin β1, and Contributes to Melanomagenesis

2010

Filamin A (FLNA) is an integrator of cell mechanics and signaling. The spreading and migration observed in FLNA sufficient A7 melanoma cells but not in the parental FLNA deficient M2 cells have been attributed to FLNA. In A7 and M2 cells, the normal prion (PrP) exists as pro-PrP, retaining its glycosylphosphatidyl-inositol (GPI) anchor peptide signal sequence (GPI-PSS). The GPI-PSS of PrP has a FLNA binding motif and binds FLNA. Reducing PrP expression in A7 cells alters the spatial distribution of FLNA and organization of actin and diminishes cell spreading and migration. Integrin β1 also binds FLNA. In A7 cells, FLNA, PrP, and integrin β1 exist as two independent, yet functionally linked,…

α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice.

2011

The arginine-glycine-aspartate (RGD) motif in fibronectin (FN) represents the major binding site for α5β1 and αvβ3 integrins. Mice lacking a functional RGD motif in FN (FN(RGE/RGE)) or α5 integrin develop identical phenotypes characterized by embryonic lethality and a severely shortened posterior trunk with kinked neural tubes. Here we show that the FN(RGE/RGE) embryos arrest both segmentation and axis elongation. The arrest is evident at about E9.0, corresponding to a stage when gastrulation ceases and the tail bud-derived presomitic mesoderm (PSM) induces α5 integrin expression and assumes axis elongation. At this stage cells of the posterior part of the PSM in wild type embryos are tight…

Timescale-dependent stock market comovement: BRICs vs. developed markets

2014

This paper examines the differences in the asset return comovement of the BRIC countries (Brazil, Russia, India and China), the other developed economies in their regions (Canada, Hong Kong and Australia) and the major industrialized economies (the U.K., Germany and Japan) with respect to the U.S. for different return periods. The novelty of the paper is that the stock return indices are decomposed to several timescales using wavelet analysis and that the results are further used as inputs for the dynamic conditional correlation (DCC) framework, which is used as a measure of comovement. The results propose that the level of stock market comovement depends on regional aspects, the level of d…

Gabapentin in the treatment of hemifacial spasm

2001

Objectives To evaluate the efficacy of gabapentin in the treatment of hemifacial spasm. Material and methods Twenty-three patients with hemifacial spasm not suitable for surgery or therapy with botulinum toxin were treated with gabapentin. The main efficacy parameter was the percentage of spasm reduction. Results A clinically significant reduction of spasms was obtained by 16 patients. Conclusion Gabapentin was effective and safe in reducing hemifacial spasm in 16 out 23 (69.6%) patients.

Visually produced locomotion in an autokinetic setup.

1987

On individual ttials, 15 subjects stood G m before a minicomputer screen displaying a colon in a completely darkened room Subjects were aware that the light source wzs stationary. They were instructed to fixate the colon and to perform nonlocomotive jogging in place for 2 min. and continuously to report their sensations. Room lights were turned on after 30 sec., and subjects' deviations from their starting places were measured. All subjects had moved toward the light source (M = 4.42 m, SD = .43) although they were convinced that they had not moved. Instead, they had reported either the light source approached them or the light source became larger and/or more intense. On a second trial, su…

Molecular “Pincer” from a Diimidazolium Salt: A Study of Binding Ability

2013

The anion recognition ability of the dicationic imidazolium salt 3,3′-di-n-octyl-1,1′- (1,3-phenylenedimethylene)diimidazolium 1,5-naphthalenedisulfonate ([m-Xyl-(oim)2][1,5-NDS]) was investigated in acetonitrile solution by means of proton NMR titrations. A wide range of anions, comprising simple inorganic ions, halides, and mono- and dicarboxylates was taken into account. The study showed that this receptor binds carboxylate anions more strongly than halides. Moreover [m- Xyl-(oim)2][1,5-NDS] displays selectivity for di- over monocarboxylate anions. The complex stability was mainly affected by the anion basicity in the presence of monocarboxylates, whereas the flexibility of the alkyl cha…

„Służba Boża Kościoła” Josefa Andreasa Jungmanna szerokie pojmowanie liturgii i jego krytyka

2018

W pierwszej części artykułu omówiono kontrowersyjne poglądy J.A. Jungmanna, uznające za liturgię szeroko rozumianą „służbę Bożą Kościoła”. Natomiast przedmiotem drugiej części opracowania jest polemika związana z reflksją Jungmanna odnośnie do definicji liturgii. Jungmann pozostawał wierny promowanemu przez siebie dość ogólnie sformułowanemu określeniu liturgii, podkreślając potrzebę właściwego pojmowania użytych w nim terminów. Wywołana jego stanowiskiem polemika jest przykładem merytorycznej dyskusji, wnoszącej godny przypomnienia wkład w rozwój myśli teologicznej.

Storia dell'Arte in Europa. Inghilterra

2014

Il saggio si offre come guida alla lettura dei maggiori fenomeni artistici fioriti in Inghilterra nel XIX secolo e affronta la genesi e lo sviluppo di tendenze e movimenti straordinari che si estendono dal Gothic Revival alle Arts and Crafts, dai Preraffaelliti all'Aesthetic Movement, dal Japonisme all'Art Nouveau. Il volume, ampiamente illustrato e corredato di bibliografia aggiornata, traccia un quadro storico-critico dell'età vittoriana senza tralasciare l'analisi delle maggiori opere d'arte dell'epoca, realizzata da artisti quali William Morris, Dante Gabriel Rossetti, Albert Moore, Lawrence Alma-Tadema, Aubrey Beardsley e molti altri autori, oggi al centro di un rinnovato interesse da …

Conflicts of Jurisdiction in Criminal Proceedings in Europe: Between Bis In Idem and Lis Pendens

2018

The purpose of this paper is to highlight the main issues concerning conflicts of jurisdiction within the EU, also from an italian perspective. The reason of conflicts of jurisdiction’s increase lies in the non-full application of the territoriality criterion, but especially in the transformation of criminality: the opening of borders and free movement of people, as well as the using of IT tools, can cause a fragmentation, among different countries, in the commission of crimes. The discussion on the overlap of proceedings for the same facts involving the same person revolves around various sources of law. Because of interpretative difficulties, many questions regarding conflicts of jurisdic…