Search results for "Movement"

Discovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype

2011

In this report, we propose the combination of computational methods and in vivo primary screening in zebrafish larvae and confirmatory in mice models as a novel strategy to accelerate anti-inflammatory drug discovery. Initially, a database of 1213 organic chemicals with great structural variability - 587 of them anti-inflammatory agents plus 626 compounds with other clinical uses - was divided into training and test groups. Atom-based quadratic indices - a TOMOCOMD-CARDD molecular descriptors family - and linear discriminant analysis (LDA) were used to develop a total of 13 models to describe the anti-inflammatory activity. The best model (Eq. (13)) shows an accuracy of 87.70% in the traini…

Dissecting the Phenotype and Genotype of PLA2G6-Related Parkinsonism.

2022

Background Complex parkinsonism is the commonest phenotype in late-onset PLA2G6-associated neurodegeneration. Objectives The aim of this study was to deeply characterize phenogenotypically PLA2G6-related parkinsonism in the largest cohort ever reported. Methods We report 14 new cases of PLA2G6-related parkinsonism and perform a systematic literature review. Results PLA2G6-related parkinsonism shows a fairly distinct phenotype based on 86 cases from 68 pedigrees. Young onset (median age, 23.0 years) with parkinsonism/dystonia, gait/balance, and/or psychiatric/cognitive symptoms were common presenting features. Dystonia occurred in 69.4%, pyramidal signs in 77.2%, myoclonus in 65.2%, and cere…

Libre circulation des travailleurs dans l'Union Européenne et tutelle des droits individuels de retraite complémentaire: un chantier inachevé

2013

Freedom of movement of workers within the EU implies adequate regulation of risks incurred by workers on the occasion of the exercise of this freedom. Among these risks, there is the possibility for community workers to lose or at least find themselves unable to give their supplementary retirement pension individual rights an unitary and continuous character when they decide to settle in another member State. What are the legislative solutions already proposed by the Community legislature and even those expected by community workers to be protected from these dangers? Provide a draft answer to this question is the main concern of this work.

Pedagogia Nowego Człowieka ks. Franciszka Blachnickiego

2016

DEUTEROKATECHUMENALNA KATECHEZA MŁODZIEŻY W UJĘCIU SŁUGI BOŻEGO KS. FRANCISZKA BLACHNICKIEGO

2022

Artykuł jest próbą ukazania deuterokatechumenalnej koncepcji katechezy młodzieżowej w ujęciu sługi Bożego ks. Franciszka Blachnickiego. Ta oryginalna i rodzima propozycja kerygmatycznej odnowy katechezy jest cennym wkładem w rozwój pedagogiki katolickiej w Polsce. Ze względu na ścisły związek z ideałami soborowej deklaracji o wychowaniu chrześcijańskim, jednocześnie realizuje dzieło inicjacji, wychowania i nauczania, a skupiając się na spotkaniu z Bogiem i człowiekiem w Biblii i sakramentach Kościoła, jest głęboko związana z parafią i jej życiem liturgicznym. Posiada wszystkie cechy pojęcia rozumianego jako systemowe uporządkowanie poznania rzeczywistości edukacyjnej, czyli nieustannej peda…

2016

The neural systems supporting speech and sign processing are very similar, although not identical. In a previous fTCD study of hearing native signers (Gutierrez-Sigut, Daws, et al., 2015) we found stronger left lateralization for sign than speech. Given that this increased lateralization could not be explained by hand movement alone, the contribution of motor movement versus ‘linguistic’ processes to the strength of hemispheric lateralization during sign production remains unclear. Here we directly contrast lateralization strength of covert versus overt signing during phonological and semantic fluency tasks. To address the possibility that hearing native signers’ elevated lateralization ind…

Head movements in Finnish Sign Language on the basis of Motion Capture data

2015

This paper reports a study of the forms and functions of head movements produced in the dimension of depth in Finnish Sign Language (FinSL). Specifically, the paper describes and analyzes the phonetic forms and prosodic, grammatical, communicative, and textual functions of nods, head thrusts, nodding, and head pulls occurring in FinSL data consisting of a continuous dialogue recorded with motion capture technology. The analysis yields a novel classification of the kinematic characteristics and functional properties of the four types of head movement. However, it also reveals that there is no perfect correspondence between form and function in the head movements investigated.

Breaking down the word length effect on readers’ eye movements

2015

Previous research on the effect of word length on reading confounded the number of letters (NrL) in a word with its spatial width. Consequently, the extent to which visuospatial and attentional-linguistic processes contribute to the word length effect on parafoveal and foveal vision in reading and dyslexia is unknown. Scholars recently suggested that visual crowding is an important factor for determining an individual’s reading speed in fluent and dyslexic reading. We studied whether the NrL or the spatial width of target words affects fixation duration and saccadic measures in natural reading in fluent and dysfluent readers of a transparent orthography. Participants read natural sentences …

Eye tracking and the translation process: reflections on the analysis and interpretation of eye-tracking data

2014

Eye tracking has become increasingly popular as a quantitative research method in translation research. This paper discusses some of the major methodological issues involved in the use of eye tracking in translation research. It focuses specifically on challenges in the analysis and interpretation of eye-tracking data as reflections of cognitive processes during translation. Four types of methodological issues are discussed in the paper. The first part discusses the preparatory steps that precede the actual recording of eye-tracking data. The second part examines critically the general assumptions linking eye movements to cognitive processing in the context of translation research. The thir…

Pied-piping domains and adjunction coincide in Finnish

2012

It is well-known thatwh-pronouns may pied-pipe their containing host phrases as they move to their final scope positions. In Finnish, such pied-piping requires further that awh-element is situated at the left edge of host phrases, a position in which it ends up either through base generation or throughwh-movement. This article investigates which independent properties define such pied-piping domains. An empirical generalization will be defended according to which a phrase constitutes such pied-piping domain if and only if it is adjoinable. The hypothesis that pied-piping domains are islands is put into question. Secondarywh-movement, pied-piping and adjunction are thus intrinsically linked …