Search results for "Multicenter"

showing 10 items of 378 documents

Characteristics of liver cirrhosis in Italy: results from a multicenter national study.

2004

Abstract Background. In 1992, the characteristics of liver cirrhosis in Italy were assessed in a cross-sectional study among 1829 cirrhosis patients attending 21 tertiary centres. Aim. To evaluate the characteristics of cirrhosis patients 9 years later. Patients. A total of 2185 consecutive cirrhosis patients were enrolled over a 6-month period in 79 hospitals located throughout Italy, randomly selected by means of systematic cluster sampling. Results. The main agent associated with cirrhosis was hepatitis C virus, which was found in 69.9% of the patients and was the only etiologic factor in 51.1% of the patients. Hepatitis B surface antigen was present in the serum of 13.0% of the cases (i…

Liver CirrhosisMaleHBsAgmedicine.medical_specialtyCirrhosisEpidemiologyCross-sectional studyHepatitis C virusPopulationmedicine.disease_causeGastroenterologyInternal medicineSurveys and QuestionnairesEpidemiologymedicinePrevalenceHumansMulticenter Studies as TopicSex DistributioneducationAgededucation.field_of_studyHepatitis B Surface AntigensHepatologybusiness.industryGastroenterologyHepatitis CMiddle Agedmedicine.diseaseHepatitis BHepatitis CCross-Sectional StudiesItalyHepatocellular carcinomaFemalebusinessDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
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Head-to-head comparison of plasma cTnI concentration values measured with three high-sensitivity methods in a large Italian population of healthy vol…

2019

Abstract Background The study aim is to compare cTnI values measured with three high-sensitivity (hs) methods in apparently healthy volunteers and patients admitted to emergency department (ED) with acute coronary syndrome enrolled in a large multicentre study. Methods Heparinized plasma samples were collected from 1511 apparently healthy subjects from 8 Italian clinical institutions (mean age: 51.5 years, SD: 14.1 years, range: 18–65 years, F/M ratio:0.95). All volunteers denied chronic or acute diseases and had normal values of routine laboratory tests. Moreover, 1322 heparinized plasma sample were also collected by 9 Italian clinical institutions from patients admitted to ED with clinica…

Male0301 basic medicineprincipal component analysisvery elderlyClinical BiochemistryheparinizationBiochemistryPatient Admission0302 clinical medicineReference ValuesLimit of Detectionblood analysisTroponin IHealthy volunteers80 and overMyocardial infarctionAcute coronary syndrome; Cardiac troponins; High-sensitivity methods; Myocardial infarction; Reference population values; Acute Coronary Syndrome; Adolescent; Adult; Aged; Aged 80 and over; Blood Chemical Analysis; Female; Humans; Italy; Male; Middle Aged; Myocardium; Patient Admission; Reference Values; Troponin I; Young Adult; Emergency Service Hospital; Healthy Volunteers; Limit of DetectionReference population valuescomparative studyHigh-sensitivity methodsAged 80 and overemergency wardEmergency Servicehospital emergency servicetroponin I acute coronary syndromeSettore BIO/12clinical trialGeneral Medicinecardiac troponin 1 CLIAMiddle AgedHealthy Volunteerspriority journalItaly030220 oncology & carcinogenesisCardiac troponinFemaleAcute coronary syndromeEmergency Service HospitalAdultmedicine.medical_specialtyAcute coronary syndromecardiac muscleAdolescentHead to headheart infarctionArticleYoung AdultHospital03 medical and health sciencesbloodInternal medicinemedicinesexHumanscontrolled studyADVIA Centaurdiagnostic test accuracy studyhumannormal humanproceduresAgedbusiness.industryMyocardiumTroponin IBiochemistry (medical)reference valueEmergency departmentmedicine.diseasemajor clinical studyhospital admissionyoung adult Acute Coronary SyndromeHigh-sensitivity methodMyocardial infarctionmulticenter study030104 developmental biologySettore BIO/12 - Biochimica Clinica E Biologia Molecolare Clinicaageprotein blood levelReference valuesCardiac troponinsbusinessmetabolismBlood Chemical Analysis
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The titanium-made growth-guidance technique for early-onset scoliosis at minimum 2-year follow-up: A prospective multicenter study.

2019

Background The management of early-onset scoliosis (EOS) remains a serious challenge in pediatric orthopedics. The growth-guidance system (GGS) is a surgical option that allows continuous growth along a rod, averting the need for repeated operative lengthening. Objectives The objective of this study was to evaluate the outcomes of the GGS in the treatment of EOS. Material and methods A prospective study, including 81 patients from 4 departments treated with this method from 2013 to 2015, was conducted with a minimum follow-up period of 24 months. The follow-up data of 57 patients was available, thus the drop-out rate was 29.63%. There were 44 girls with a mean age of 10.03 years and 13 boys…

Male030213 general clinical medicinemedicine.medical_specialtyMedicine (miscellaneous)ScoliosisspineGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineInternal MedicinemedicineHumansPharmacology (medical)Prospective StudiesProspective cohort studyChildearly-onset scoliosisGenetics (clinical)TitaniumCobb anglebusiness.industryImplant failureMean ageProstheses and Implantsmedicine.diseaseSurgeryPediatric orthopedicsTreatment OutcomeMulticenter studyScoliosisReviews and References (medical)FemaleEarly onset scoliosisbusinessFollow-Up StudiesAdvances in clinical and experimental medicine : official organ Wroclaw Medical University
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Improve hip fracture outcome in the elderly patient (iHOPE) : A study protocol for a pragmatic, multicentre randomised controlled trial to test the e…

2018

IntroductionHip fracture surgery is associated with high in-hospital and 30-day mortality rates and serious adverse patient outcomes. Evidence from randomised controlled trials regarding effectiveness of spinal versus general anaesthesia on patient-centred outcomes after hip fracture surgery is sparse.Methods and analysisThe iHOPE study is a pragmatic national, multicentre, randomised controlled, open-label clinical trial with a two-arm parallel group design. In total, 1032 patients with hip fracture (>65 years) will be randomised in an intended 1:1 allocation ratio to receive spinal anaesthesia (n=516) or general anaesthesia (n=516). Outcome assessment will occur in a blinded manner aft…

Male1682medicine.medical_specialtyArthroplasty Replacement HipMedizinAnesthesia GeneralAnesthesia Spinallaw.inventionAnaesthesia03 medical and health sciencesClinical Trial Protocols as TopicPostoperative Complications0302 clinical medicineRandomized controlled trial030202 anesthesiologylawPragmatic Clinical Trials as TopicProtocolClinical endpointHumansMulticenter Studies as TopicMedicineGeneral anaesthesia1506ddc:610030212 general & internal medicineAgedRandomized Controlled Trials as TopicPain PostoperativeHip fracturegeriatric medicineHip Fracturesbusiness.industryMedical recordanaesthesia in orthopaedicsGeneral MedicinePerioperativeMiddle Agedmedicine.diseaseanaestheticsClinical trialTelephone interviewResearch DesignPhysical therapyFemalebusiness
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Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database

2018

Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiog…

MaleARDSmodelos logísticosDatabases Factualmedicine.medical_treatment[SDV]Life Sciences [q-bio]humanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Kaplan-Meier EstimateCritical Care and Intensive Care MedicineAcute respiratory failureSeverity of Illness IndexCohort Studiesrandomized-trial0302 clinical medicineMechanical ventilationRisk Factorsestudios prospectivosEpidemiology80 and overicuMedicineProspective StudiesProspective cohort studyestudios de cohortesImmunodeficiencymediana edadestadísticasAged 80 and overRespiratory Distress Syndromeancianocritically-ill patientsRespirationresultado del tratamientorespiraciónStatisticslcsh:Medical emergencies. Critical care. Intensive care. First aidadultoMiddle Aged3. Good healthfailureIntensive Care UnitsTreatment OutcomeArtificialCohortprospective multicenterImmunocompromised patientsAcute respiratory failure; ARDS; Immunocompromised patients; Mechanical ventilation; Noninvasive ventilation; Critical Care and Intensive Care MedicineFemaleNoninvasive ventilationHumanestimación de Kaplan-MeierAdultmedicine.medical_specialtyLogistic ModelIntensive Care UnitSocio-culturaleunidades de cuidados intensivossurvivalStatistics NonparametricSepsisDatabases03 medical and health sciencesImmunocompromised HostInternal medicineImmunocompromised patientcancerfactores de riesgoHumansNonparametricíndice de gravedad de la enfermedadintensive-care-unitFactualAgedMechanical ventilationbusiness.industryResearchRisk FactorRespiratory Distress Syndrome Adult030208 emergency & critical care medicinelcsh:RC86-88.9medicine.diseaseRespiration ArtificialPneumoniaProspective StudieLogistic Models030228 respiratory systemmalignanciesARDShuésped inmunodeprimidoCohort StudiebusinessAcute respiratory failure; ARDS; Immunocompromised patients; Mechanical ventilation; Noninvasive ventilation; Adult; Aged; Aged 80 and over; Cohort Studies; Databases Factual; Female; Humans; Intensive Care Units; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Risk Factors; Severity of Illness Index; Statistics Nonparametric; Treatment Outcome; Immunocompromised Host
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Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study

2016

Rationale: Noninvasive ventilation (NIV) is increasingly used in patients with acute respiratory distress syndrome (ARDS). The evidence supporting NIV use in patients with ARDS remains relatively sparse.Objectives: To determine whether, during NIV, the categorization of ARDS severity based on the PaO2/FiO2 Berlin criteria is useful.Methods: The LUNG SAFE (Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure) study described the management of patients with ARDS. This substudy examines the current practice of NIV use in ARDS, the utility of the PaO2/FiO2 ratio in classifying patients receiving NIV, and the impact of NIV on outcome.Measurements and Main…

MaleARDSprocedureblood oxygen tensionCritical Care and Intensive Care MedicineSeverity of Illness Indexlaw.invention0302 clinical medicinelawHospital MortalityRespiratory Distress SyndromeAcute respiratory distress syndromeadult respiratory distress syndromeMiddle AgedIntensive care unitIntensive Care Unitsmedicine.anatomical_structureTreatment Outcomepriority journalpositive end expiratory pressureNoninvasive ventilationdisease severityFemaletreatment outcome AgedNoninvasive ventilationprospective studyHumanAdultPulmonary and Respiratory Medicinemedicine.medical_specialtycohort analysiIntensive Care Unitdisease classificationAcute respiratory distressArticleNO03 medical and health sciencesacute respiratory distress syndrome; noninvasive ventilationlength of staySeverity of illnessSettore MED/41 - ANESTESIOLOGIAmedicineSequential Organ Failure Assessment ScoreHumansIn patientAcute respiratory distress syndrome; Noninvasive ventilation; Aged; Female; Hospital Mortality; Humans; Intensive Care Units; Male; Middle Aged; Respiratory Distress Syndrome Adult; Severity of Illness Index; Treatment Outcome; Noninvasive Ventilation; Pulmonary and Respiratory Medicine; Critical Care and Intensive Care MedicineIntensive care medicineoutcome assessmentAgedLungbusiness.industryRespiratory Distress Syndrome Adult030208 emergency & critical care medicinemedicine.diseasemajor clinical studymortalityrespiratory tract diseasesbreathing ratemulticenter study030228 respiratory systemincidenceObservational studyobservational studybusinessAcute respiratory distress syndrome; Noninvasive ventilation;
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Aging and disability affect misdiagnosis of COPD in elderly asthmatics: the SARA study

2003

STUDY OBJECTIVES: This study investigated to what extent a diagnosis of COPD is erroneously made or the disease remains unrecognized in elderly asthmatic patients, and identified factors leading to misdiagnosis and underdiagnosis of asthma in such patients. DESIGN: A multicenter study involving 24 Italian pulmonary or geriatric institutions. PATIENTS: One hundred twenty-eight asthmatic patients (98 women, 76.6%) aged 73 +/- 6.4 years (mean +/- SD) were selected from the cohort of the Salute Respiratoria nell'Anziano (respiratory health in the elderly) study. METHODS: All patients underwent a clinical evaluation that included clinical history and spirometry with a bronchodilator test. A diag…

MaleAge FactorsSettore MED/10 - Malattie Dell'Apparato RespiratorioAsthmaDiagnosis DifferentialDisability EvaluationPulmonary Disease Chronic ObstructiveForced Expiratory VolumeHumansMulticenter Studies as TopicAge FactorFemaleGeriatric AssessmentAgedHumanRespiratory Sounds
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Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for …

2015

Background Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included…

MaleAgingPediatricsNutrition and DiseaseDatabases FactualDisease030204 cardiovascular system & hematologyGlobal HealthMedical and Health SciencesDOUBLE-BLIND0302 clinical medicineAdolescent; Adult; Aged; Aged 80 and over; Cause of Death; Child; Child Mortality; Child Preschool; Databases Factual; Female; Global Health; Humans; Infant; Infant Newborn; Life Expectancy; Life Tables; Male; Middle Aged; Models Statistical; Mortality; Sex Distribution; Young AdultModelsVoeding en ZiekteCause of DeathEpidemiologyGlobal health80 and over2.2 Factors relating to the physical environmentLife Tables030212 general & internal medicineAetiologyChildINFLUENZAE TYPE-B11 Medical and Health SciencesCause of deathPediatricAged 80 and overPLACEBO-CONTROLLED-TRIALLife TableMortality rateMedicine (all)1. No povertyGeneral MedicineCHILDHOOD PNEUMONIAMiddle AgedStatistical3. Good healthInfectious DiseasesChild PreschoolPNEUMOCOCCAL CONJUGATE VACCINEChild MortalityFemaleInfectionLife Sciences & BiomedicineHumanAdultmedicine.medical_specialtyAdolescentINTEGRATED APPROACHCHILDREN YOUNGER187 COUNTRIESDatabase03 medical and health sciencesDatabasesYoung AdultMedicine General & InternalLife ExpectancyGeneral & Internal MedicinemedicineLife ScienceHumansMortalitySex DistributionPreschoolFactualVLAGAgedScience & TechnologyModels Statisticalbusiness.industryPreventionPOPULATION HEALTHInfant NewbornENTERIC MULTICENTERInfantGBD 2013 Mortality and Causes of Death CollaboratorsNewbornVerbal autopsyChild mortalityGood Health and Well BeingLife expectancyRISK-FACTORSbusiness2.4 Surveillance and distributionDemographyModel
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From Global Initiative for Chronic Obstructive Lung Disease (GOLD) Guidelines to Current Clinical Practice

2006

Background: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines have been promulgated to improve the management of chronic obstructive pulmonary disorder (COPD). Objective: To evaluate the extent to which the current therapeutic approach to COPD conforms to GOLD guidelines. Methods: This was a multicentre observational study of elderly COPD patients enrolled for acute care in general medicine or geriatric wards in tertiary hospitals in Italy in April 2002. Our series consisted of 471 patients >64 years of age consecutively admitted for acute exacerbations of COPD to wards participating in the study. Data describing drugs used prior to exacerbation and prescribed at …

MaleAgingmedicine.medical_specialtyDrug IndustryPharmacological therapyGuidelines as Topicurologic and male genital diseasesPulmonary Disease Chronic ObstructivePharmacotherapyOdds RatiomedicineHumansMulticenter Studies as TopicPharmacology (medical)Practice Patterns Physicians'Intensive care medicineAgedCOPDbusiness.industryRespiratory diseaseTiotropium bromidemedicine.diseaseDrug UtilizationObstructive lung diseaserespiratory tract diseasesClinical PracticeLung diseasePhysical therapyFemaleGuideline AdherenceAcute Exacerbation Tiotropium Methylxanthine Tiotropium Bromide Cumulative Illness Rate ScaleGeriatrics and Gerontologybusinessmedicine.drugDrugs & Aging
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Incidence and risk factors of post-engraftment invasive fungal disease in adult allogeneic hematopoietic stem cell transplant recipients receiving or…

2015

Studies that analyze the epidemiology and risk factors for invasive fungal disease (IFD) after engraftment in alloSCT are few in number. This single-center retrospective study included 404 alloSCT adult recipients surviving > 40 days who engrafted and were discharged without prior IFD. All patients who received >= 20 mg/day of prednisone were assigned to primary oral prophylaxis (itraconazole or low-dose voriconazole). The primary end point was the cumulative incidence (CI) of probable/proven IFD using the European Organization for Research and Treatment of Cancer and Mycoses Study Group (EORTC/MSG) criteria. The independent prognostic factors after multivariate analyses were used to constr…

MaleAntifungal AgentsTransplantation ConditioningPremedicationmedicine.medical_treatmentMULTICENTERAdministration OralHematopoietic stem cell transplantationEchinocandinsCOMPETING RISKCaspofunginRisk FactorsCause of DeathINFECTIONGranulocyte Colony-Stimulating FactorEPIDEMIOLOGYCumulative incidenceTreatment FailureFramingham Risk ScoreIncidenceIncidence (epidemiology)Hematopoietic Stem Cell TransplantationHematologyMiddle AgedAllograftsHematologic NeoplasmsVORICONAZOLEDrug Therapy CombinationFemaleASPERGILLOSISRisk assessmentFungemiamedicine.drugAdultmedicine.medical_specialtyNeutropeniaANTIFUNGAL PROPHYLAXISNeutropeniaRisk AssessmentITRACONAZOLEMedication AdherenceImmunocompromised HostLipopeptidesYoung AdultAmphotericin BInternal medicinemedicineAspergillosisHumansAgedRetrospective StudiesVoriconazoleTransplantationbusiness.industryRetrospective cohort studyFLUCONAZOLETriazolesmedicine.diseaseSurvival AnalysisSurgeryMycosesPatient CompliancebusinessSCT
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