Search results for "Multifunction"
showing 10 items of 100 documents
Quantifying and easing conflicting goals between interest groups in natural resource planning
2019
Management of natural resources at the regional level is a compromise between a variety of objectives and interests. At the local level, management of the forests depends upon the ownership structure, with forest owners using their forests as they see fit. A potential conflict occurs if the forest owners’ management decisions are counter to the interests of society in general or the industry that relies on the forest resource as their raw material. We explore the intensity of this conflict at the regional level in several large boreal forest production landscapes. To explore the conflict, we investigate three main interest groups: (i) economically oriented forest owners; (ii) industry grou…
Managing boreal forests for the simultaneous production of collectable goods and timber revenues
2016
Timber Production is an economically important provisioning ecosystem service in forests, but is often in conflict with the provision of other ecosystem services. In multifunctional forestry, the production of timber and non-timber ecosystem services should coexist in the same landscape. To this end, we explored the capacity of a boreal landscape to simultaneously produce collectable goods − bilberry (Vaccimium myrtillus L.), cowberry (Vaccinium vitis-idaea L.) and cep (Boletus edulis Bull.) − alongside timber revenues. We also identified optimal forest management plans to achieve this. Furthermore, we analyzed trade-offs between collectable good yields and timber production, as well as bet…
Small endogenous molecules as moiety to improve targeting of CNS drugs.
2016
A major challenge in the development of novel neuro-therapeutic agents is to effectively overcome the blood-brain barrier (BBB), which acts as a 'working dynamic barrier'. The core problem in the treatment of neurodegenerative diseases is failed delivery of potential medicines due to their inadequate permeation rate. Areas covered: The present review gives a summary of endogenous moieties used in synthesizing prodrugs, derivatives and bioisosteric drugs appositely designed to structurally resemble physiological molecular entities able to be passively absorbed or carried by specific carrier proteins expressed at BBB level. In particular, this overview focuses on aminoacidic, glycosyl, purine…
Engineered Functional Redundancy Relaxes Selective Constraints upon Endogenous Genes in Viral RNA Genomes
2018
Functional redundancy, understood as the functional overlap of different genes, is a double-edge sword. At the one side, it is thought to serve as a robustness mechanism that buffers the deleterious effect of mutations hitting one of the redundant copies, thus resulting in pseudogenization. At the other side, it is considered as a source of genetic and functional innovation. In any case, genetically redundant genes are expected to show an acceleration in the rate of molecular evolution. Here, we tackle the role of functional redundancy in viral RNA genomes. To this end, we have evaluated the rates of compensatory evolution for deleterious mutations affecting an essential function, the suppr…
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study
2010
Background— Recent genome-wide association studies (GWAS) of myocardial infarction (MI) and other forms of coronary artery disease (CAD) have led to the discovery of at least 13 genetic loci. In addition to the effect size, power to detect associations is largely driven by sample size. Therefore, to maximize the chance of finding novel susceptibility loci for CAD and MI, the Coronary ARtery DIsease Genome-wide Replication And Meta-analysis (CARDIoGRAM) consortium was formed. Methods and Results— CARDIoGRAM combines data from all published and several unpublished GWAS in individuals with European ancestry; includes >22 000 cases with CAD, MI, or both and >60 000 controls; and unifies …
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
2011
1. The CARDIoGRAM Consortium. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 2011;43:333–338. ### Study Hypothesis Recently, genome-wide association studies (GWAS) have identified several common variants that are associated with risk of coronary artery disease (CAD) and myocardial infarction (MI). The authors state that the current loci discovered in CAD and MI GWAS explain only a small fraction of the heritability of this complex disease. The authors hypothesized that a larger study would provide more power to discover common variants with modest effect sizes. Therefore, they formed the Coronary ARtery DIsease Genome-wid…
Evaluation of Nanostructured Coatings for the Protection of Apuan Marble Stone
2019
Nowadays the use of multifunctional nanomaterials has significantly increased with interesting applications for the cultural heritage conservation sector, leading to the definition and use of products with innovative properties. Therefore, a preliminary validation of the performances and behavior over time of these treatments becomes an unavoidable key point for a correct use of these products before being applied to historical materials, in order to avoid irreparable damage over time. In this direction, the aim of this study was to evaluate the effectiveness of the treatment with multifunctional nanostructured products on Apuan marble. The focus of the work was to test methods to accelerat…
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness…
2011
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions a…
Parte II Cap. I L'impresa agricola
2021
This chapter takes into account the transformations that have taken place with regard to the discipline of the agricultural enterprise and its new functions
MR2553995 (2010h:26008): Mihail, Alexandru The Arzela-Ascoli theorem for partial defined functions. An. Univ. Bucureşti Mat. 57 (2008), no. 2, 259–26…
2008
In this paper the author gives a generalization of the Arzela-Ascoli theorem for partial defined functions, i.e., for functions defined in a nonempty subset of a metric space X and taking values in a metric space Y. To this end suitable definitions of local and uniform convergence for partial defined functions are introduced. As an application a different proof of a known result concerning the existence of Lipschitz selections for Lipschitz multifunctions is given. Reviewed by Luisa Di Piazza