Search results for "Multiple"
showing 10 items of 2678 documents
Cognition in Interaction : Challenges in Assessing Persons with Sensory and Multiple disabilities
2021
This article reports a qualitative study of cognitive assessments of three teenagers with sensory and multiple disabilities, including moderate to profound developmental disability. The aim was to evaluate the possibilities for adapting standardized tests and the implementation of interactional partnership in assessment. Cognitive assessments were made with an individually-adapted psychological assessment tool, the Bayley Scales of Infant and Toddler Development. The assessment situations were video-recorded and analyzed based on sociocultural theories of early interaction, dynamic assessment, and the bodily-tactile modality of cognition. The results showed that the requirements for assessm…
Representational consistency and the learning of forces in upper secondary school physics
2013
Investigating the success of ERP systems in Pakistan : end-users' perspective
2016
The global business environment is changing rapidly, and organisations from developing countries such as Pakistan have to re-engineer their business processes to meet the challenges of increased competition and rising customer expectations. Enterprise resource planning (ERP) systems intend to deliver many benefits, such as business automation, reduced operating costs, accurate demand forecasts, better decision-making and improved customer service. However, organisations adopting ERP systems encounter many types of problems that may lead to failures in processes, expectations and interactions. In order to address these failures, researchers have identified the critical success factors in the…
The efficacy of anaerobic training on multiple sclerosis symptoms management
2021
Purpose: the aim of this study was to investigated the improvement of physical health status and reduce the chronic fatigue associated with that pathology in people with multiple sclerosis following lactacid anaerobic training protocol. Methods: 8 subjects (age: 34,88 ± 4,45) affected by multiple sclerosis (EDSS < 3.5) were involved in our study. An anaerobic lactacid training was administered for 12 weeks, 2 times a week, an hour and a half for each session. At the beginning (T0), at the end of the study (T1) and after 9 months from the end of the study (Follow-up, FU) physical parameters (body compositions analysis; strength, balance and reaction tests; Visual Analog Fatigue Scale, VAF…
A methodological framework based on a DANP model for evaluating the software quality in terms of usability: a preliminary investigation on mobile ope…
2020
Evaluation of the software usability as concerns software alternatives represents a typical Multi- Criteria Decision-Analysis (MCDA) problem. Such a kind of problem can be successfully faced via structured models and approaches which validity have been widely shown in literature. In this work, a methodological framework based on a MCDA model integrating the DEMATEL method along with the ANP technique is proposed and explained with more detail to address the relevant issue of the software usability evaluation. The applicability of the considered DEMATEL-ANP (DANP) based model in the under analysis contest is demonstrated via a preliminary investigation, where the usability of the two major M…
Decision-Making Tools to Manage the Microbiology of Drinking Water Distribution Systems
2020
[EN] This paper uses a two-fold multi-criteria decision-making (MCDM) approach applied for the first time to the field of microbial management of drinking water distribution systems (DWDS). Specifically, the decision-making trial and evaluation laboratory (DEMATEL) was applied removing the need for reliance on expert judgement, and analysed interdependencies among water quality parameters and microbiological characteristics of DWDS composed of different pipe materials. In addition, the fuzzy technique for order preference by similarity to ideal solution (FTOPSIS) ranked the most common bacteria identified during trials in a DWDS according to their relative abundance while managing vagueness…
Osteoclast Immunosuppressive Effects in Multiple Myeloma: Role of Programmed Cell Death Ligand 1
2018
Immunomodulatory drugs and monoclonal antibody-based immunotherapies have significantly improved the prognosis of the patients with multiple myeloma (MM) in the recent years. These new classes of reagents target malignant plasma cells (PCs) and further modulate the immune microenvironment, which prolongs anti-MM responses and may prevent tumor occurrence. Since MM remains an incurable cancer for most patients, there continues to be a need to identify new tumor target molecules and investigate alternative cellular approaches using gene therapeutic strategies and novel treatment mechanisms. Osteoclasts (OCs), as critical multi-nucleated large cells responsible for bone destruction in >80% …
The prognostic and predictive value of IKZF1 and IKZF3 expression in T-cells in patients with multiple myeloma
2018
Purpose: While recent studies described the role of IKZF1/3 proteins in multiple myeloma (MM) cells, few have highlighted the significance of IKZF1/3 expression in T-cells. In this study we examine the prognostic and predictive value of IKZF1/3 expression in T-cells in patients with MM stage III. Experimental design: We analysed the IKZF1/3 expression levels in T-cells from 45 MM stage I (MMI) and 50 newly diagnosed MM stage III (MMIII) patients, according to Durie-Salmon staging system, by flow cytometry to examine their prognostic and predictive value. We also combined in vivo observations with in vitro assays to determine the effect of IKZF1/3 expression on the T-cell immunophenotype and…
Targeting B Cell Maturation Antigen (BCMA) in Multiple Myeloma: Potential Uses of BCMA-Based Immunotherapy
2018
The approval of the first two monoclonal antibodies targeting CD38 (daratumumab) and SLAMF7 (elotuzumab) in late 2015 for treating relapsed and refractory multiple myeloma (RRMM) was a critical advance for immunotherapies for multiple myeloma (MM). Importantly, the outcome of patients continues to improve with the incorporation of this new class of agents with current MM therapies. However, both antigens are also expressed on other normal tissues including hematopoietic lineages and immune effector cells, which may limit their long-term clinical use. B cell maturation antigen (BCMA), a transmembrane glycoprotein in the tumor necrosis factor receptor superfamily 17 (TNFRSF17), is expressed a…
Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes
2021
Myeloid cell arginase-mediated arginine depletion with consecutive inhibition of T cell functions is a key component of tumor immune escape. Both, granulocytic myeloid-derived suppressor cells (G-MDSC) and conventional mature human polymorphonuclear neutrophil granulocytes (PMN) express high levels of arginase 1 and can act as suppressor cells of adaptive anti-cancer immunity. Here we demonstrate that pharmacological inhibition of PMN-derived arginase 1 not only prevents the suppression of T cell functions but rather leads to a strong hyperactivation of T cells. Human PMN were incubated in cell culture medium in the absence or presence of an arginase inhibitor. T cells from healthy donors w…